ZNF24 - zinc finger protein 24 Gene

Homo sapiens

Also known as KOX17; RSG-A; ZNF191; ZSCAN3; Zfp191

Gene ID: 7572 | Gene type: protein coding

About ZNF24

Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38): 18:35,332,227-35,344,420 (from NCBI)

This gene has 6 transcripts (splice variants), 105 orthologues and 31 paralogues. Ubiquitous expression in thyroid (RPKM 22.0), brain (RPKM 18.9) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF24 Products(3)

mRNA	Protein	Name
NM_001308123.2	NP_001295052.1	zinc finger protein 24 isoform 2
NM_001375815.1	NP_001362744.1	zinc finger protein 24 isoform 1
NM_006965.4	NP_008896.2	zinc finger protein 24 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11532988	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	31515488	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11532988	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10585455	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11532988	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF24 Protein Structure

SCAN

zf-H2C2_2

0
100
200
300
368 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 24

retinoic acid suppression protein A

ZNF24 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF24	P17028	ZSCAN22	Homo sapiens	P10073	Y2H Array	32296183
Intra	ZNF24	P17028	ZSCAN22	Homo sapiens	P10073	Y2H Prey Pooling	32296183
Intra	ZNF24	P17028	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	ZNF24	P17028	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	ZNF24	P17028	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	ZNF24	P17028	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	32296183
Intra	ZNF24	P17028	ZNF483	Homo sapiens	Q6P088	Y2H Array	25416956
Intra	ZNF24	P17028	ZSCAN21	Homo sapiens	Q9Y5A6	Validated Y2H	32296183
Intra	ZNF24	P17028	PGBD1	Homo sapiens	Q96JS3	Y2H Array	31515488
Intra	ZNF24	P17028	PGBD1	Homo sapiens	Q96JS3	Y2H Array	25416956
Intra	ZNF24	P17028	ZNF174	Homo sapiens	Q15697-2	Validated Y2H	32296183
Intra	ZNF24	P17028	ZNF174	Homo sapiens	Q15697-2	Anti Tag CoIP	28514442
Intra	ZNF24	P17028	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	ZNF24	P17028	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	ZNF24	P17028	LMO2	Homo sapiens	P25791-3	Validated Y2H	32296183
Intra	ZNF24	P17028	ZNF444	Homo sapiens	Q8N0Y2-2	Validated Y2H	32296183
Intra	ZNF24	P17028	APOE	Homo sapiens	P02649	Validated Y2H	32814053
Intra	ZNF24	P17028	APOE	Homo sapiens	P02649	Y2H Array	32814053
Intra	ZNF24	P17028	APOE	Homo sapiens	P02649	Y2H Pooling	32814053
Intra	ZNF24	P17028	ZNF396	Homo sapiens	Q96N95-3	Validated Y2H	32296183
Intra	ZNF24	P17028	ZNF396	Homo sapiens	Q96N95-3	Y2H Array	32296183
Intra	ZNF24	P17028	ZNF396	Homo sapiens	Q96N95-3	Y2H Prey Pooling	32296183
Intra	ZNF24	P17028	ZNF396	Homo sapiens	Q96N95-3	MAPPIT	32296183
Intra	ZNF24	P17028	MAP1LC3C	Homo sapiens	Q9BXW4	Validated Y2H	32296183
Intra	ZNF24	P17028	ZKSCAN4	Homo sapiens	Q969J2	Y2H Array	31515488
Intra	ZNF24	P17028	ZKSCAN4	Homo sapiens	Q969J2	Validated Y2H	32296183
Intra	ZNF24	P17028	SQSTM1	Homo sapiens	Q13501	Validated Y2H	32814053
Intra	ZNF24	P17028	SQSTM1	Homo sapiens	Q13501	Y2H Array	32814053
Intra	ZNF24	P17028	SQSTM1	Homo sapiens	Q13501	Y2H Pooling	32814053
Intra	ZNF24	P17028	DDX6	Homo sapiens	P26196	Validated Y2H	25416956
Intra	ZNF24	P17028	DDX6	Homo sapiens	P26196	Y2H Prey Pooling	25416956
Intra	ZNF24	P17028	DDX6	Homo sapiens	P26196	Y2H Array	25416956
Intra	ZNF24	P17028	ZNF446	Homo sapiens	Q9NWS9	Anti Tag CoIP	28514442
Intra	ZNF24	P17028	ZNF446	Homo sapiens	Q9NWS9	Anti Tag CoIP	33961781
Intra	ZNF24	P17028	ZNF446	Homo sapiens	Q9NWS9	Y2H Array	20211142
Intra	ZNF24	P17028	ZNF620	Homo sapiens	Q6ZNG0	Validated Y2H	32296183
Intra	ZNF24	P17028	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	ZNF24	P17028	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	ZNF24	P17028	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ZNF24	P17028	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ZNF24	P17028	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ZNF24	P17028	ZSCAN23	Homo sapiens	Q3MJ62	Validated Y2H	32296183
Intra	ZNF24	P17028	ZSCAN32	Homo sapiens	Q9NX65	Y2H Prey Pooling	25416956
Intra	ZNF24	P17028	ZSCAN32	Homo sapiens	Q9NX65	Validated Y2H	25416956
Intra	ZNF24	P17028	ZSCAN32	Homo sapiens	Q9NX65	Y2H Array	25416956
Intra	ZNF24	P17028	ZSCAN32	Homo sapiens	Q9NX65	Y2H Pooling	16189514
Intra	ZNF24	P17028	YJU2B	Homo sapiens	P13994	Y2H Pooling	16189514
Intra	ZNF24	P17028	YJU2B	Homo sapiens	P13994	Y2H Array	31515488
Intra	ZNF24	P17028	YJU2B	Homo sapiens	P13994	Y2H Prey Pooling	32296183
Intra	ZNF24	P17028	YJU2B	Homo sapiens	P13994	Y2H Array	32296183
Intra	ZNF24	P17028	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
Intra	ZNF24	P17028	ZSCAN16	Homo sapiens	Q9H4T2	Validated Y2H	32296183
Intra	ZNF24	P17028	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	ZNF24	P17028	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	ZNF24	P17028	ZNF446	Homo sapiens	Q9NWS9-2	Y2H Prey Pooling	25416956
Intra	ZNF24	P17028	ZNF446	Homo sapiens	Q9NWS9-2	Complementation	32296183
Intra	ZNF24	P17028	ZNF446	Homo sapiens	Q9NWS9-2	Y2H Pooling	16189514
Intra	ZNF24	P17028	ZNF446	Homo sapiens	Q9NWS9-2	Validated Y2H	32296183
Intra	ZNF24	P17028	ZNF446	Homo sapiens	Q9NWS9-2	MAPPIT	32296183
Intra	ZNF24	P17028	ZNF165	Homo sapiens	P49910	Y2H Array	32296183
Intra	ZNF24	P17028	ZNF165	Homo sapiens	P49910	Y2H Prey Pooling	32296183
Intra	ZNF24	P17028	ZNF165	Homo sapiens	P49910	Validated Y2H	32296183
Intra	ZNF24	P17028	SCAND1	Homo sapiens	P57086	Validated Y2H	32296183
Intra	ZNF24	P17028	SCAND1	Homo sapiens	P57086	Y2H Pooling	16189514
Intra	ZNF24	P17028	SCAND1	Homo sapiens	P57086	Anti Tag CoIP	28514442
Intra	ZNF24	P17028	SCAND1	Homo sapiens	P57086	Anti Tag CoIP	33961781
Intra	ZNF24	P17028	APLP1	Homo sapiens	P51693	Y2H Pooling	16169070
Intra	ZNF24	P17028	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32296183
Intra	ZNF24	P17028	TCAF1	Homo sapiens	Q9Y4C2	Y2H Prey Pooling	25416956
Intra	ZNF24	P17028	TCAF1	Homo sapiens	Q9Y4C2	Y2H Array	25416956
Intra	ZNF24	P17028	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
Intra	ZNF24	P17028	DZIP3	Homo sapiens	Q86Y13	Y2H Array	29892012
Intra	ZNF24	P17028	DZIP3	Homo sapiens	Q86Y13	Y2H Prey Pooling	25416956
Intra	ZNF24	P17028	DZIP3	Homo sapiens	Q86Y13	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16114	ZNF24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZNF24	VGNC	VGNC:107735
Mus musculus	ZNF24	MGD	MGI:1929704
Macaca mulatta	ZNF24	VGNC	VGNC:81614
Rattus norvegicus	ZNF24	RGD	RGD:727963
Bos taurus	ZNF24	VGNC	VGNC:37232
Canis familiaris	ZNF24	VGNC	VGNC:48680

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