C1QL4 - complement C1q like 4 Gene

Homo sapiens

Also known as CTRP11; C1QTNF11

Gene ID: 338761 | Gene type: protein coding

About C1QL4

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,332,409-49,337,188 (from NCBI)

This gene has 1 transcript (splice variant), 261 orthologues and 23 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Apr 2022]

C1QL4 Products(1)

mRNA	Protein	Name
NM_001008223.2	NP_001008224.1	complement C1q-like protein 4 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QL4 Protein Structure

C1q

0
100
200
238 a.a.

Protein Preferred Names

Protein Names

complement C1q-like protein 4

C1q and tumor necrosis factor-related protein 11

C1QL4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	C1QL4	Q86Z23	IL10RA	Homo sapiens	Q13651	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	IL10RA	Homo sapiens	Q13651	Y2H Array	32296183
Intra	C1QL4	Q86Z23	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	C1QL4	Q86Z23	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	C1QL4	Q86Z23	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	C1QL4	Q86Z23	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	C1QL4	Q86Z23	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Array	32296183
Intra	C1QL4	Q86Z23	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	C1QL4	Q86Z23	RHCG	Homo sapiens	Q9UBD6	Y2H Array	32296183
Intra	C1QL4	Q86Z23	RHCG	Homo sapiens	Q9UBD6	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	RHCG	Homo sapiens	Q9UBD6	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	C1QL4	Q86Z23	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	C1QL4	Q86Z23	TRHR	Homo sapiens	P34981	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	TRHR	Homo sapiens	P34981	Y2H Array	32296183
Intra	C1QL4	Q86Z23	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	C1QL4	Q86Z23	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	C1QL4	Q86Z23	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	C1QL4	Q86Z23	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	C1QL4	Q86Z23	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	C1QL4	Q86Z23	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	C1QL4	Q86Z23	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	C1QL4	Q86Z23	SLC38A1	Homo sapiens	Q9H2H9	Y2H Prey Pooling	32296183
Intra	C1QL4	Q86Z23	SLC38A1	Homo sapiens	Q9H2H9	Y2H Array	32296183
Intra	C1QL4	Q86Z23	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myositis Fibrosa

Interstitial Myositis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01725	C1QL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	C1QL4	VGNC	VGNC:38581
Mus musculus	C1QL4	MGD	MGI:3579909
Rattus norvegicus	C1QL4	RGD	RGD:1565968
Bos taurus	C1QL4	VGNC	VGNC:106661
Macaca mulatta	C1QL4	VGNC	VGNC:70450

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