2. Gene
  3. IFNAR2 - interferon alpha and beta receptor subunit 2 Gene

IFNAR2 - interferon alpha and beta receptor subunit 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC

Gene ID: 3455 | Gene type: protein coding

About IFNAR2

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,229,938-33,265,664 (from NCBI)

This gene has 14 transcripts (splice variants), 303 orthologues, 11 paralogues and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 13.0), appendix (RPKM 12.7) and 24 other tissues.

Summary

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]

IFNAR2 Products(8)

mRNA Protein Name
NM_000874.5 NP_000865.2 interferon alpha/beta receptor 2 isoform b
NM_001385055.1 NP_001371984.1 interferon alpha/beta receptor 2 isoform e
NM_001385054.1 NP_001371983.1 interferon alpha/beta receptor 2 isoform d
NM_001289128.2 NP_001276057.1 interferon alpha/beta receptor 2 isoform c
NM_207584.3 NP_997467.1 interferon alpha/beta receptor 2 isoform b
NM_207585.3 NP_997468.1 interferon alpha/beta receptor 2 isoform a
NM_001289125.3 NP_001276054.1 interferon alpha/beta receptor 2 isoform a
NM_001289126.2 NP_001276055.1 interferon alpha/beta receptor 2 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytokine binding IPI
IPI: Inferred from physical interaction
8798579 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7665574 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
7759950 GOA
enables type I interferon binding IPI
IPI: Inferred from physical interaction
7759950 GOA
enables type I interferon receptor activity IDA
IDA: Inferred from direct assay
7665574 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
7759950 GOA
involved in cellular response to interferon-beta IDA
IDA: Inferred from direct assay
7759950 GOA
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
26424569 GOA
involved in response to interferon-alpha IDA
IDA: Inferred from direct assay
7759950 GOA
involved in response to interferon-alpha IMP
IMP: Inferred from mutant phenotype
26424569 GOA
involved in response to interferon-beta IDA
IDA: Inferred from direct assay
7759950 GOA
involved in response to interferon-beta IMP
IMP: Inferred from mutant phenotype
26424569 GOA
involved in type I interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
7665574 GOA
involved in type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
26424569 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
7759950 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
7759950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNAR2 Protein Structure

Tissue_fac

Tissue_fac: Tissue factor (12 - 118)

Interfer-bind

Interfer-bind: Interferon-alpha/beta receptor, fibronectin type III (133 - 229)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 515 a.a.
Protein Preferred Names Protein Names

interferon alpha/beta receptor 2

IFN-R-2

IFN-alpha/beta receptor 2

IFNalpha/beta receptor subunit 2

human interferon alpha/beta receptor

interferon (alpha, beta and omega) receptor 2

interferon alpha binding protein

interferon receptor

interferon-alpha/beta receptor beta chain

type I interferon receptor 2

IFNAR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IFNAR2 P48551 STAT1 Homo sapiens P42224
Pull Down
9121453
Intra
IFNAR2 P48551 JAK1 Homo sapiens P23458
Anti Tag CoIP
16710296
Intra
IFNAR2 P48551 JAK1 Homo sapiens P23458
Pull Down
16710296
Intra
IFNAR2 P48551 STAT2 Homo sapiens P52630
Pull Down
9121453
Intra
IFNAR2 P48551 STAT2 Homo sapiens P52630
Anti Bait CoIP
17923090
Intra
IFNAR2 P48551 STAT2 Homo sapiens P52630
Anti Tag CoIP
17923090
Intra
IFNAR2 P48551 RACK1 Homo sapiens P63244
Y2H
11046044
Intra
IFNAR2 P48551 RACK1 Homo sapiens P63244
Pull Down
11046044
Intra
IFNAR2 P48551 USP18 Homo sapiens Q9UMW8
Anti Tag CoIP
16710296
Intra
IFNAR2 P48551 IFNA2 Homo sapiens P01563
X-Ray Diffraction
21854986
Intra
IFNAR2 P48551 IRF9 Homo sapiens Q00978
Anti Bait CoIP
17923090
Intra
IFNAR2 P48551 IRF9 Homo sapiens Q00978
Far-WB
17923090
Intra
IFNAR2 P48551 PDLIM1 Homo sapiens O00151
Anti Tag CoIP
33961781
Intra
IFNAR2 P48551 CREBBP Homo sapiens Q92793
Anti Tag CoIP
17923090
Intra
IFNAR2 P48551 CREBBP Homo sapiens Q92793
Anti Bait CoIP
17923090
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNAR2 Proteins

Cat. No. Product Name Accession Purity
HY-P72613 IFN-alpha/beta R2 Protein, Human (HEK293, His) P48551-1 (I27-K243) ≥95%
HY-P74860 IFN-alpha/beta R2 Protein, Human (HEK293, hFc) P48551-1 (I27-K243) ≥95%
HY-P74861 IFN-alpha/beta R2 Protein, Human (Biotinylated, HEK293, His) P48551-1 (I27-K243) ≥95%
HY-P74862A IFN-alpha/beta R2 Protein, Human (HEK293, His, solution) P48551-1 (I27-K243) ≥95%

Related Diseases

Diseases Alias
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos
Multisystem Inflammatory Syndrome In Children

Mis-C

Multisystem Inflammatory Disorder In Children And Adolescents

Paediatric Inflammatory Multisystemic Syndrome

Mic
Immunodeficiency 28

IMD28

Ifngr2 Deficiency

Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive

Immunodeficiency 28, Mycobacteriosis

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency

Msmd Due To Complete Ifngammar2 Deficiency

Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency

Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency

Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency

Immunodeficiency, Type 28, Mycobacteriosis
Torch Syndrome
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Immunodeficiency 45

IMD45
Rubella

German Measles

Three Day Measles

Rubella Nos
Immunodeficiency 44

IMD44
Viral Infectious Disease

Arbovirus Infections

Viral Disease

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Herpangina

Vesicular Pharyngitis
Immunodeficiency 39

IMD39

Immunodeficiency, Type 39
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Mumps

Parotitis Due To Mumps Virus

Mumps Nos

Epidemic Parotitis

Infectious Parotitis
West Nile Encephalitis

West-Nile Encephalitis

West Nile Fever

West Nile Fever Encephalitis

West Nile Fever With Encephalitis

West-Nile Fever

Encephalitis, West Nile Fever
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Primary Immunodeficiency With Post-Measles-Mumps-Rubella Vaccine Viral Infection

Primary Immunodeficiency With Post-Mmr Vaccine Viral Infection
Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W063968 RO8191 ≥99.0% Unkown
HY-RS06583 Ifnar2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06582 IFNAR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06584 Ifnar2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IFNAR2 VGNC VGNC:30055
Rattus norvegicus IFNAR2 RGD RGD:1583177
Macaca mulatta IFNAR2 VGNC VGNC:81330
Felis catus IFNAR2 VGNC VGNC:103734
Mus musculus IFNAR2 MGD MGI:1098243
Macaca fascicularis IFNAR2 NCBI NCBI:102140083
Others IFNAR2 NCBI