ILF2 - interleukin enhancer binding factor 2 Gene

Homo sapiens

Also known as NF45; PRO3063

Gene ID: 3608 | Gene type: protein coding

About ILF2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,661,788-153,670,993 (from NCBI)

This gene has 5 transcripts (splice variants), 248 orthologues and 14 paralogues. Ubiquitous expression in testis (RPKM 65.5), bone marrow (RPKM 58.7) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the MicroRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

ILF2 Products(2)

mRNA	Protein	Name
NM_001267809.2	NP_001254738.1	interleukin enhancer-binding factor 2 isoform 2
NM_004515.4	NP_004506.2	interleukin enhancer-binding factor 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7519613	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	10574923	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9442054	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11739746	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	11790298	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21123651	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ILF2 Protein Structure

DZF

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

interleukin enhancer-binding factor 2

interleukin enhancer binding factor 2, 45kD

Related Diseases

Diseases

Alias

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Childhood Endodermal Sinus Tumor

Childhood Endodermal Sinus Neoplasm	Childhood Endodermal Sinus Tumour
Paediatric Yolk Sac Tumour	Pediatric Yolk Sac Tumor
Childhood Yolk Sac Tumor

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06785	ILF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ILF2	MGD	MGI:1915031
Felis catus	ILF2	VGNC	VGNC:67790
Rattus norvegicus	ILF2	RGD	RGD:1305734
Macaca mulatta	ILF2	VGNC	VGNC:99982
Canis familiaris	ILF2	VGNC	VGNC:41999
Bos taurus	ILF2	VGNC	VGNC:30175

Name
Email *

	Sorry, but the email address you supplied was invalid.