TIRAP - TIR domain containing adaptor protein Gene

Homo sapiens

Also known as Mal; wyatt; BACTS1; MyD88-2

Gene ID: 114609 | Gene type: protein coding

About TIRAP

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,283,093-126,294,933 (from NCBI)

This gene has 16 transcripts (splice variants), 188 orthologues and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 2.7), ovary (RPKM 2.6) and 25 other tissues.

Summary

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

TIRAP Products(4)

mRNA	Protein	Name
NM_001039661.2	NP_001034750.1	toll/interleukin-1 receptor domain-containing adapter protein isoform a
NM_001318776.2	NP_001305705.1	toll/interleukin-1 receptor domain-containing adapter protein isoform b
NM_001318777.2	NP_001305706.1	toll/interleukin-1 receptor domain-containing adapter protein isoform a
NM_148910.3	NP_683708.1	toll/interleukin-1 receptor domain-containing adapter protein isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Toll-like receptor 2 binding	IPI IPI: Inferred from physical interaction	19509286	GOA
enables Toll-like receptor 4 binding	IPI IPI: Inferred from physical interaction	19509286	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17258210	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	11544529	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11544529	GOA
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	17161867	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	16751103	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	15294994	GOA
involved in TIRAP-dependent toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	11544529	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11544529	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	11544529	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	19509286	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19509286	GOA
involved in positive regulation of interleukin-15 production	IDA IDA: Inferred from direct assay	18583567	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16301656	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	16301656	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	12062447	GOA
involved in positive regulation of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	19509286	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	19509286	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16301656	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	11544529	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	16751103	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell surface	IDA IDA: Inferred from direct assay	12447441	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19948740	GOA
is active in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	16751103	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	16751103	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19948740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIRAP Protein Structure

TIR_2

0
100
200
221 a.a.

Protein Preferred Names

Protein Names

toll/interleukin-1 receptor domain-containing adapter protein

MyD88 adapter-like protein

TIRAP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TIRAP	P58753	LTN1	Homo sapiens	O94822	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	SAMHD1	Homo sapiens	Q9Y3Z3	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	33961781
Intra	TIRAP	P58753	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	ARAF	Homo sapiens	P10398	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	17583698
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Pull Down	17583698
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	11544529
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	21334391
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	33961781
Intra	TIRAP	P58753	MYD88	Homo sapiens	Q99836	MAPPIT	17258210
Intra	TIRAP	P58753	IRAK2	Homo sapiens	O43187	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	IRAK4	Homo sapiens	Q9NWZ3	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	TIRAP	Homo sapiens	P58753	X-Ray Diffraction	24275656
Intra	TIRAP	P58753	TLR4	Homo sapiens	O00206	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	TIRAP	Homo sapiens	P58753	MAPPIT	17258210
Intra	TIRAP	P58753	CCDC47	Homo sapiens	Q96A33	Anti Tag CoIP	21903422
Intra	TIRAP	P58753	PIK3R1	Homo sapiens	P27986	IF	19574958

Cross: Cross-species interaction Intra: Intraspecies interaction

TIRAP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82844	TIRAP Antibody (YA2589)	WB	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Bacteremia 1

Bacteremia, Susceptibility To, 1	BACTS1
Bacteremia, Protection Against	Bacteremia, Susceptibility To, Type 1

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Bacteriuria

Pelvic Inflammatory Disease

Pid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14551	TIRAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TIRAP	VGNC	VGNC:107652
Felis catus	TIRAP	VGNC	VGNC:104335
Rattus norvegicus	TIRAP	RGD	RGD:1595496
Bos taurus	TIRAP	VGNC	VGNC:35879
Mus musculus	TIRAP	MGD	MGI:2152213
Canis familiaris	TIRAP	VGNC	VGNC:47384

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