BAG5 - Bag5 BAG cochaperone 5 Gene

Rattus norvegicus

Also known as Bag5l1

Gene ID: 366734 | Gene type: protein coding

About BAG5

Summary

Enables chaperone binding activity and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of protein refolding; negative regulation of ubiquitin-protein transferase activity; and regulation of inclusion body assembly. Predicted to be located in inclusion body; mitochondrion; and perinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleus. Orthologous to human BAG5 (BAG cochaperone 5). [provided by Alliance of Genome Resources, Apr 2022]

BAG5 Products(1)

mRNA	Protein	Name
NM_001008526.2	NP_001008526.1	BAG family molecular chaperone regulator 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21358815	RGD
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	15603737	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15603737	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein refolding	IMP IMP: Inferred from mutant phenotype	15603737	RGD
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	15603737	RGD
involved in negative regulation of ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	15603737	RGD
involved in regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	15603737	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

BAG family molecular chaperone regulator 5

BAG-5	BCL2-associated athanogene 5
BCL2-associated athanogene 5-like 1	bcl-2-associated athanogene 5

BAG5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Bag5	Q5QJC9	STUB1	Homo sapiens	Q9UNE7	SLC	21358815
Cross	Bag5	Q5QJC9	STUB1	Homo sapiens	Q9UNE7	Pull Down	21358815
Cross	Bag5	Q5QJC9	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	21358815

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01346	BAG5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	BAG5	NCBI	NCBI:9529

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