ITGAV - integrin subunit alpha V Gene

Homo sapiens

Also known as CD51; MSK8; VNRA; VTNR

Gene ID: 3685 | Gene type: protein coding

About ITGAV

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:186,590,056-186,680,901 (from NCBI)

This gene has 23 transcripts (splice variants), 243 orthologues, 17 paralogues and is associated with 73 phenotypes. Ubiquitous expression in thyroid (RPKM 45.9), ovary (RPKM 36.3) and 24 other tissues.

Summary

The product of this gene belongs to the Integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate LIGHT and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This Integrin may regulate angiogenesis and Cancer progression. Alternative splicing results in multiple transcript variants. Note that the Integrin alpha 5 and Integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

ITGAV Products(3)

mRNA	Protein	Name
NM_001144999.3	NP_001138471.2	integrin alpha-V isoform 2 precursor
NM_001145000.3	NP_001138472.2	integrin alpha-V isoform 3 precursor
NM_002210.5	NP_002201.2	integrin alpha-V isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to C-X3-C chemokine binding	IDA IDA: Inferred from direct assay	23125415	GOA
enables extracellular matrix binding	IDA IDA: Inferred from direct assay	22505472	GOA
enables extracellular matrix protein binding	IDA IDA: Inferred from direct assay	7525578	GOA
contributes to fibroblast growth factor binding	IDA IDA: Inferred from direct assay	18441324	GOA
enables fibronectin binding	IDA IDA: Inferred from direct assay	24658351	GOA
contributes to insulin-like growth factor I binding	IDA IDA: Inferred from direct assay	19578119	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	20826760	GOA
contributes to neuregulin binding	IDA IDA: Inferred from direct assay	20682778	GOA
enables protease binding	IDA IDA: Inferred from direct assay	22505472	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1694173	GOA
enables voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	18395422	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IEP IEP: Inferred from expression pattern	11866539	GOA
involved in apolipoprotein A-I-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23726972	GOA
involved in apoptotic cell clearance	IGI IGI: Inferred from genetic interaction	20826760	GOA
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	18395422	GOA
involved in cell adhesion	IDA IDA: Inferred from direct assay	10218736	GOA
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	12807887	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	26934001	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	7525578	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	19933311	GOA
involved in endodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	23154389	GOA
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20563599	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	11970960	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	26934001	GOA
involved in negative chemotaxis	IMP IMP: Inferred from mutant phenotype	23726972	GOA
involved in negative regulation of entry of bacterium into host cell	IDA IDA: Inferred from direct assay	10570297	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	10708943	GOA
involved in negative regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	15215180	GOA
involved in negative regulation of lipid transport	IMP IMP: Inferred from mutant phenotype	15215180	GOA
involved in negative regulation of lipoprotein metabolic process	IMP IMP: Inferred from mutant phenotype	15215180	GOA
acts upstream of or within negative regulation of low-density lipoprotein receptor activity	IMP IMP: Inferred from mutant phenotype	15215180	GOA
involved in negative regulation of macrophage derived foam cell differentiation	IMP IMP: Inferred from mutant phenotype	15215180	GOA
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	10708943	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19578119	GOA
involved in positive regulation of intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	26934001	GOA
involved in positive regulation of small GTPase mediated signal transduction	IMP IMP: Inferred from mutant phenotype	26934001	GOA
involved in regulation of phagocytosis	IDA IDA: Inferred from direct assay	10570297	GOA
involved in substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	24658351	GOA
involved in symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	25063885	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of alphav-beta3 integrin-HMGB1 complex	IDA IDA: Inferred from direct assay	20826760	GOA
part of alphav-beta3 integrin-IGF-1-IGF1R complex	IDA IDA: Inferred from direct assay	19578119	GOA
located in cell surface	IDA IDA: Inferred from direct assay	1918072	GOA
located in filopodium membrane	IDA IDA: Inferred from direct assay	25063885	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	17158881	GOA
part of integrin alphav-beta1 complex	IPI IPI: Inferred from physical interaction	25398877	GOA
part of integrin alphav-beta3 complex	IDA IDA: Inferred from direct assay	20826760	GOA
part of integrin alphav-beta3 complex	IPI IPI: Inferred from physical interaction	11546839	GOA
part of integrin alphav-beta5 complex	IDA IDA: Inferred from direct assay	25063885	GOA
part of integrin alphav-beta5 complex	IPI IPI: Inferred from physical interaction	1694173	GOA
part of integrin alphav-beta6 complex	IDA IDA: Inferred from direct assay	22278742	GOA
part of integrin alphav-beta6 complex	IPI IPI: Inferred from physical interaction	25383667	GOA
part of integrin alphav-beta8 complex	IDA IDA: Inferred from direct assay	1918072	GOA
part of integrin alphav-beta8 complex	IPI IPI: Inferred from physical interaction	30061598	GOA
part of integrin complex	IDA IDA: Inferred from direct assay	15215180	GOA
located in lamellipodium membrane	IDA IDA: Inferred from direct assay	25063885	GOA
located in microvillus membrane	IDA IDA: Inferred from direct assay	25063885	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21310825	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	25063885	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGAV Protein Structure

FG-GAP

Integrin_alpha2

Integrin_alpha

0
200
400
600
800
1048 a.a.

Protein Preferred Names

Protein Names

integrin alpha-V

antigen identified by monoclonal antibody L230

Recombinant ITGAV Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72535	Integrin alpha V beta 8 Protein, Human (HEK293, His)	P06756-1 (F31-V992)&P26012-1 (E43-R684)	≥95%
HY-P73865	Integrin alpha V beta 8 Protein, Human (HEK293, His, solution)	P06756-1 (F31-V992)&P26012-1 (E43-R684)	≥95%
HY-P73867	Integrin alpha V beta 6 Protein, Human (HEK293, Flag-His)	P06756-1 (F31-V992)&P18564-1 (G22-N707)	≥95%
HY-P73868	Integrin alpha V beta 3 Protein, Human (HEK293, His, solution)	P06756-1 (F31-V992)&P05106-1 (G27-D718)	≥95%
HY-P77719	Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P05106-1 (G27-D718)	≥95%
HY-P77720	Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P18084 (G24-N719)	≥95%
HY-P77721	Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P18564-1 (G22-N707)	≥95%
HY-P77722	Integrin alpha V beta 8 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P26012-1 (E43-R684)	≥95%

Related Diseases

Diseases

Alias

West Nile Virus

West Nile Virus, Susceptibility To	Wnv
Wnv, Susceptibility To	West Nile Viral Infection
Encephalitis, West Nile Fever	West Nile Fever

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Priapism

Mentulagra	Priapism, Familial Idiopathic
Familial Idiopathic Priapism	Pathologic Erection
Painful Erection

Insulin-Like Growth Factor I

Insulin-Like Growth Factor I Deficiency	IGF1 DEFICIENCY
Insulin-Like Growth Factor I, Resistance To	Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency	Growth Delay Due To Insulin-Like Growth Factor I Resistance
IGF1RES	Igf-I Resistance
Somatomedin, End-Organ Insensitivity To	Somatomedin-C
Somatomedin-C, Resistance To	Growth Retardation With Sensorineural Deafness And Mental Retardation
Insulin-Like Growth Factor 1 Resistance To	Igf-1 Resistance
Somatomedin End-Organ Insensitivity To	Somatomedin-C Resistance To
Growth Restriction With Sensorineural Deafness And Intellectual Disability	Growth Delay-Deafness-Intellectual Disability Syndrome
Growth Delay-Hearing Loss-Intellectual Disability Syndrome	Igf-1 Deficiency
Primary Insulin-Like Growth Factor Deficiency	Resistance To Igf-1
Insulin-Like Growth Factor 1 Resistance	End-Organ Insensitivity To Somatomedin
Igf1 Resistance	Resistance To Insulin-Like Growth Factor I
Resistance To Somatomedin-C	Insulin-Like Growth Factor 1, Resistance To

Pharyngoconjunctival Fever

Pharyngo-Conjunctival Fever	Adenoviral Pharyngoconjunctivitis
Adenovirus Infections, Human

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Mouth Disease

Mouth Diseases

Mouth Disorders

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Kaposi'S Sarcoma-Associated Herpesvirus
Multiple Idiopathic Pigmented Hemangiosarcoma	Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To
African Lymphadenopathic Kaposi'S Sarcoma	Anal Kaposi'S Sarcoma
Cardiac Kaposi'S Sarcoma	Central Nervous System Kaposi'S Sarcoma
Conjunctival Kaposi'S Sarcoma	Corneal Kaposi'S Sarcoma
Cutaneous Kaposi'S Sarcoma	Esophageal Kaposi'S Sarcoma
Gallbladder Kaposi'S Sarcoma	Gastric Kaposi'S Sarcoma
Intestinal Kaposi'S Sarcoma	Kaposi'S Sarcoma Of Anus
Kaposi'S Sarcoma Of Central Nervous System	Kaposi'S Sarcoma Of Conjunctiva
Kaposi'S Sarcoma Of Cornea	Kaposi'S Sarcoma Of Esophagus
Kaposi'S Sarcoma Of Gastrointestinal Sites	Kaposi'S Sarcoma Of Heart
Kaposi'S Sarcoma Of Lymph Nodes	Kaposi'S Sarcoma Of Penis
Kaposi'S Sarcoma Of Skin	Kaposi'S Sarcoma Of Soft Tissues
Kaposi'S Sarcoma Of The Cns	Kaposi'S Sarcoma Of The Gallbladder
Kaposi'S Sarcoma Of The Prostate	Kaposi'S Sarcoma, Lung
Kaposi'S Sarcoma, Skin	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Bone Giant Cell Tumor

Giant Cell Tumor Of Bone	Osteoclastoma
Gct Of Bone	Bone Giant Cell Tumour
Giant Cell Myeloma	Giant Cell Neoplasm Of Bone
Giant Cell Tumour Of Bone

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pigmented Villonodular Synovitis

Diffuse Giant Cell Tumor Of Tenosynovium	Villous Tenosynovitis
Diffuse Pigmented Villonodular Synovitis	Diffuse-Type Gct
Diffuse-Type Giant Cell Tumor	Localized Pigmented Villonodular Synovitis
Tgct	Tsgct
Tenosynovial Giant Cell Tumor	Tenosynovial Giant Cell Tumors
Synovitis Pigmented Villonodular	Synovitis, Pigmented Villonodular
Fibrous Histiocytoma Of Tendon Sheath	Testicular Germ Cell Tumor
Chronic Haemorrhagic Villous Synovitis	Pvns - [Pigmented Villonodular Synovitis]
Villonodular Synovitis

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia	Thrombasthenia Of Glanzmann And Naegeli
Glanzmann'S Thrombasthenia	Bdplt2
Platelet Glycoprotein Iib-Iiia Deficiency	Deficiency Of Platelet Fibrinogen Receptor
GT1	Gt
Platelet Fibrinogen Receptor Deficiency	Glycoprotein Complex Iib-Iiia Deficiency
Deficiency Of Glycoprotein Complex Iib-Iiia	Glycoprotein Iib/Iiia Defect
Glanzmann Thrombasthenia, Type A	Thrombasthenia
Bleeding Disorder, Platelet-Type, 2	Gp Iib-Iiia Complex Deficiency
Deficiency Of Gp Iib-Iiia Complex	Platelet-Type Bleeding Disorder 2
Thrombocytasthenia	Deficiency Of Gp 2b 3a Complex
Diacyclothrombopathia 2b 3a	Glanzmann Thrombasthenia Type A
Platelet Fibrinogen Receptor, Deficiency Of	Platelet Glycoprotein 2b 3a Deficiency
Glanzmann Disease	Glanzmann-Naegeli Disorder
Hereditary Hemorrhagic Thrombasthenia	Hereditary Thrombasthenia
Bleeding Disorder Platelet-Type 2

Bone Benign Neoplasm

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Intrahepatic Bile Duct Adenoma

Adenoma Of Intrahepatic Bile Duct

Adenoma Of The Intrahepatic Bile Duct

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06961	ITGAV Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ITGAV	VGNC	VGNC:67849
Mus musculus	ITGAV	MGD	MGI:96608
Rattus norvegicus	ITGAV	RGD	RGD:1310613
Canis familiaris	ITGAV	VGNC	VGNC:42134
Macaca mulatta	ITGAV	VGNC	VGNC:73783
Bos taurus	ITGAV	VGNC	VGNC:30323
Macaca fascicularis	ITGAV	NCBI	NCBI:102116249
Others	ITGAV	NCBI

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