ITPKB - inositol-trisphosphate 3-kinase B Gene

Homo sapiens

Also known as IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB

Gene ID: 3707 | Gene type: protein coding

About ITPKB

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,631,690-226,739,282 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 9.3) and 24 other tissues.

Summary

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/Calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

ITPKB Products(2)

mRNA	Protein	Name
NM_001388404.1	NP_001375333.1	inositol-trisphosphate 3-kinase B isoform 2
NM_002221.4	NP_002212.3	inositol-trisphosphate 3-kinase B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol-1,4,5-trisphosphate 3-kinase activity	IDA IDA: Inferred from direct assay	1654894	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	1654894	GOA
involved in inositol trisphosphate metabolic process	IDA IDA: Inferred from direct assay	1654894	GOA
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	12747803	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12747803	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	12747803	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12747803	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITPKB Protein Structure

IPK

0
200
400
600
800
946 a.a.

Protein Preferred Names

Protein Names

inositol-trisphosphate 3-kinase B

IP3 3-kinase B

Related Diseases

Diseases

Alias

Maxillary Cancer

Maxillary Neoplasm	Maxillary Neoplasms
Upper Jaw Bone Cancer

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126750	GNF362	Inhibitor	99.63%	Unkown
HY-RS06989	ITPKB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ITPKB	MGD	MGI:109235
Canis familiaris	ITPKB	VGNC	VGNC:42155
Macaca mulatta	ITPKB	VGNC	VGNC:106392
Rattus norvegicus	ITPKB	RGD	RGD:2932
Felis catus	ITPKB	VGNC	VGNC:67868
Bos taurus	ITPKB	VGNC	VGNC:106787

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