2. Gene
  3. ITPKB - inositol-trisphosphate 3-kinase B Gene

ITPKB - inositol-trisphosphate 3-kinase B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB

Gene ID: 3707 | Gene type: protein coding

About ITPKB

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,631,690-226,739,282 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 9.3) and 24 other tissues.

Summary

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/Calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

ITPKB Products(2)

mRNA Protein Name
NM_001388404.1 NP_001375333.1 inositol-trisphosphate 3-kinase B isoform 2
NM_002221.4 NP_002212.3 inositol-trisphosphate 3-kinase B isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
IDA: Inferred from direct assay
1654894 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
1654894 GOA
involved in inositol trisphosphate metabolic process IDA
IDA: Inferred from direct assay
1654894 GOA
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
12747803 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12747803 GOA
located in cytoskeleton IDA
IDA: Inferred from direct assay
12747803 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12747803 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITPKB Protein Structure

IPK

IPK: Inositol polyphosphate kinase (726 - 936)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 946 a.a.
Protein Preferred Names Protein Names

inositol-trisphosphate 3-kinase B

IP3 3-kinase B

ITPKB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ITPKB P27987 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
ITPKB P27987 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
ITPKB P27987 PPP3CA Homo sapiens Q08209-2
Validated Y2H
32296183
Intra
ITPKB P27987 PPP3CA Homo sapiens Q08209-2
Y2H Array
32296183
Intra
ITPKB P27987 PPP3CA Homo sapiens Q08209-2
Y2H Prey Pooling
32296183
Intra
ITPKB P27987 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
ITPKB P27987 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
ITPKB P27987 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
ITPKB P27987 IFT88 Homo sapiens Q13099
Y2H Array
32296183
Intra
ITPKB P27987 IFT88 Homo sapiens Q13099
Y2H Prey Pooling
32296183
Intra
ITPKB P27987 IFT88 Homo sapiens Q13099
Validated Y2H
32296183
Intra
ITPKB P27987 SCAI Homo sapiens Q8N9R8
Validated Y2H
32296183
Intra
ITPKB P27987 SCAI Homo sapiens Q8N9R8
Y2H Array
32296183
Intra
ITPKB P27987 SCAI Homo sapiens Q8N9R8
Y2H Prey Pooling
32296183
Intra
ITPKB P27987 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
ITPKB P27987 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
ITPKB P27987 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
ITPKB P27987 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
ITPKB P27987 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
ITPKB P27987 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
ITPKB P27987 CTDSP1 Homo sapiens Q9GZU7
Validated Y2H
32296183
Intra
ITPKB P27987 CTDSP1 Homo sapiens Q9GZU7
Y2H Array
32296183
Intra
ITPKB P27987 CTDSP1 Homo sapiens Q9GZU7
Y2H Prey Pooling
32296183
Intra
ITPKB P27987 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
ITPKB P27987 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
ITPKB P27987 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Maxillary Cancer

Maxillary Neoplasm

Maxillary Neoplasms

Upper Jaw Bone Cancer
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126750 GNF362 Inhibitor 99.63% Unkown
HY-RS06989 ITPKB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ITPKB MGD MGI:109235
Canis familiaris ITPKB VGNC VGNC:42155
Macaca mulatta ITPKB VGNC VGNC:106392
Rattus norvegicus ITPKB RGD RGD:2932
Felis catus ITPKB VGNC VGNC:67868
Bos taurus ITPKB VGNC VGNC:106787