2. Gene
  3. ITPKB - inositol-trisphosphate 3-kinase B Gene

ITPKB - inositol-trisphosphate 3-kinase B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB

Gene ID: 3707 | Gene type: protein coding

About ITPKB

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,631,690-226,739,282 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 9.3) and 24 other tissues.

Summary

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/Calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

ITPKB Products(2)

mRNA Protein Name
NM_001388404.1 NP_001375333.1 inositol-trisphosphate 3-kinase B isoform 2
NM_002221.4 NP_002212.3 inositol-trisphosphate 3-kinase B isoform 1

ITPKB Protein Structure

IPK

IPK: Inositol polyphosphate kinase (726 - 936)

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  • 946 a.a.
Protein Preferred Names Protein Names

inositol-trisphosphate 3-kinase B

IP3 3-kinase B

Related Diseases

Diseases Alias
Maxillary Cancer

Maxillary Neoplasm

Maxillary Neoplasms

Upper Jaw Bone Cancer
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126750 GNF362 Inhibitor 99.63% Unkown
HY-RS06989 ITPKB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ITPKB MGD MGI:109235
Canis familiaris ITPKB VGNC VGNC:42155
Macaca mulatta ITPKB VGNC VGNC:106392
Rattus norvegicus ITPKB RGD RGD:2932
Felis catus ITPKB VGNC VGNC:67868
Bos taurus ITPKB VGNC VGNC:106787