NCR3LG1 - natural killer cell cytotoxicity receptor 3 ligand 1 Gene

Homo sapiens

Also known as B7H6; B7-H6; DKFZp686O24166

Gene ID: 374383 | Gene type: protein coding

About NCR3LG1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,351,800-17,381,661 (from NCBI)

This gene has 2 transcripts (splice variants), 83 orthologues and 2 paralogues. Broad expression in colon (RPKM 2.1), duodenum (RPKM 1.9) and 21 other tissues.

Summary

B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

NCR3LG1 Products(1)

mRNA	Protein	Name
NM_001202439.3	NP_001189368.1	natural cytotoxicity triggering receptor 3 ligand 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19528259	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	19528259	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NK T cell activation	IDA IDA: Inferred from direct assay	19528259	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	19528259	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCR3LG1 Protein Structure

C1-set

Gag_MA

0
100
200
300
400
454 a.a.

Protein Preferred Names

Protein Names

natural cytotoxicity triggering receptor 3 ligand 1

B7 homolog 6

NCR3LG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NCR3LG1	Q68D85	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	NCR3LG1	Q68D85	NRAC	Homo sapiens	Q8N912	Validated Y2H	32296183
Intra	NCR3LG1	Q68D85	NCR3	Homo sapiens	O14931	Confocal	24275655
Intra	NCR3LG1	Q68D85	NCR3	Homo sapiens	O14931	ELISA	24275655
Intra	NCR3LG1	Q68D85	NCR3	Homo sapiens	O14931	FACS	24275655
Intra	NCR3LG1	Q68D85	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	NCR3LG1	Q68D85	TMEM222	Homo sapiens	Q9H0R3	Validated Y2H	32296183
Intra	NCR3LG1	Q68D85	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	NCR3LG1	Q68D85	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCR3LG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7631	B7-H6 Protein, Human (HEK293, His)	Q68D85 (D25-S262)	≥95%
HY-P72839	B7-H6 Protein, Human (HEK293, Fc)	Q68D85 (D25-S262)	≥95%
HY-P78076	B7-H6 Protein, Human (Biotinylated, HEK293, His-Avi)	Q68D85 (D25-S262)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09101	NCR3LG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NCR3LG1	VGNC	VGNC:81975
Rattus norvegicus	NCR3LG1	RGD	RGD:1588614
Canis familiaris	NCR3LG1	VGNC	VGNC:52271
Macaca fascicularis	NCR3LG1	NCBI	NCBI:102121659
Others	NCR3LG1	NCBI

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