2. Gene
  3. NCR3LG1 - natural killer cell cytotoxicity receptor 3 ligand 1 Gene

NCR3LG1 - natural killer cell cytotoxicity receptor 3 ligand 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as B7H6; B7-H6; DKFZp686O24166

Gene ID: 374383 | Gene type: protein coding

About NCR3LG1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,351,800-17,381,661 (from NCBI)

This gene has 2 transcripts (splice variants), 83 orthologues and 2 paralogues. Broad expression in colon (RPKM 2.1), duodenum (RPKM 1.9) and 21 other tissues.

Summary

B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

NCR3LG1 Products(1)

mRNA Protein Name
NM_001202439.3 NP_001189368.1 natural cytotoxicity triggering receptor 3 ligand 1 precursor

NCR3LG1 Protein Structure

C1-set

C1-set: Immunoglobulin C1-set domain (160 - 239)

Gag_MA

Gag_MA: Matrix protein (MA), p15 (295 - 387)

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  • 454 a.a.
Protein Preferred Names Protein Names

natural cytotoxicity triggering receptor 3 ligand 1

B7 homolog 6

Recombinant NCR3LG1 Proteins

Cat. No. Product Name Accession Purity
HY-P7631 B7-H6 Protein, Human (HEK293, His) Q68D85 (D25-S262) ≥95%
HY-P72839 B7-H6 Protein, Human (HEK293, Fc) Q68D85 (D25-S262) ≥95%
HY-P78076 B7-H6 Protein, Human (Biotinylated, HEK293, His-Avi) Q68D85 (D25-S262) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09101 NCR3LG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NCR3LG1 VGNC VGNC:81975
Rattus norvegicus NCR3LG1 RGD RGD:1588614
Canis familiaris NCR3LG1 VGNC VGNC:52271
Macaca fascicularis NCR3LG1 NCBI NCBI:102121659
Others NCR3LG1 NCBI