2. Gene
  3. TMEM222 - transmembrane protein 222 Gene

TMEM222 - transmembrane protein 222 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C1orf160; NEDMOSBA

Gene ID: 84065 | Gene type: protein coding

About TMEM222

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,322,163-27,336,400 (from NCBI)

This gene has 11 transcripts (splice variants), 268 orthologues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 11.2), testis (RPKM 10.1) and 25 other tissues.

Summary

Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM222 Products(1)

mRNA Protein Name
NM_032125.3 NP_115501.2 transmembrane protein 222
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in dendrite IDA
IDA: Inferred from direct assay
33824500 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM222 Protein Structure

DUF778

DUF778: Protein of unknown function (DUF778) (61 - 178)

  • 0
  • 100
  • 208 a.a.
Protein Preferred Names Protein Names

transmembrane protein 222

TMEM222 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TMEM222 Q9H0R3 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra TMEM222 Q9H0R3 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra TMEM222 Q9H0R3 HIBADH Homo sapiens P31937
Y2H Array
32296183
Intra TMEM222 Q9H0R3 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra TMEM222 Q9H0R3 TMEM35A Homo sapiens Q53FP2
Y2H Array
32296183
Intra TMEM222 Q9H0R3 TMEM35A Homo sapiens Q53FP2
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra TMEM222 Q9H0R3 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra TMEM222 Q9H0R3 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra TMEM222 Q9H0R3 NCR3LG1 Homo sapiens Q68D85
Y2H Array
32296183
Intra TMEM222 Q9H0R3 NCR3LG1 Homo sapiens Q68D85
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra TMEM222 Q9H0R3 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 CLRN1 Homo sapiens P58418
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 CLRN1 Homo sapiens P58418
Y2H Array
32296183
Intra TMEM222 Q9H0R3 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra TMEM222 Q9H0R3 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra TMEM222 Q9H0R3 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra TMEM222 Q9H0R3 SLC10A2 Homo sapiens Q12908
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 SLC10A2 Homo sapiens Q12908
Y2H Array
32296183
Intra TMEM222 Q9H0R3 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra TMEM222 Q9H0R3 RNASEK Homo sapiens Q6P5S7
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 RNASEK Homo sapiens Q6P5S7
Y2H Array
32296183
Intra TMEM222 Q9H0R3 CLDN5 Homo sapiens O00501
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 CLDN5 Homo sapiens O00501
Y2H Array
32296183
Intra TMEM222 Q9H0R3 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra TMEM222 Q9H0R3 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra TMEM222 Q9H0R3 LRRC59 Homo sapiens Q96AG4
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 LRRC59 Homo sapiens Q96AG4
Y2H Array
32296183
Intra TMEM222 Q9H0R3 COMT Homo sapiens P21964
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 COMT Homo sapiens P21964
Y2H Array
32296183
Intra TMEM222 Q9H0R3 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra TMEM222 Q9H0R3 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra TMEM222 Q9H0R3 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra TMEM222 Q9H0R3 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra TMEM222 Q9H0R3 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra TMEM222 Q9H0R3 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra TMEM222 Q9H0R3 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra TMEM222 Q9H0R3 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra TMEM222 Q9H0R3 ERG28 Homo sapiens Q9UKR5
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 ERG28 Homo sapiens Q9UKR5
Y2H Array
32296183
Intra TMEM222 Q9H0R3 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra TMEM222 Q9H0R3 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra TMEM222 Q9H0R3 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra TMEM222 Q9H0R3 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra TMEM222 Q9H0R3 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra TMEM222 Q9H0R3 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra TMEM222 Q9H0R3 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra TMEM222 Q9H0R3 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities

NEDMOSBA
Brachial Plexus Neuritis

Brachial Neuritis

Parsonage-Aldren-Turner Syndrome
Osteosclerotic Myeloma
Gestational Choriocarcinoma

Gestational Chorionepithelioma

Molar Pregnancy With Choriocarcinoma
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14701 TMEM222 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TMEM222 VGNC VGNC:36043
Macaca mulatta TMEM222 VGNC VGNC:79491
Canis familiaris TMEM222 VGNC VGNC:47536
Felis catus TMEM222 VGNC VGNC:66317
Rattus norvegicus TMEM222 RGD RGD:1304793
Mus musculus TMEM222 MGD MGI:1098568