1. Gene
  2. KIR2DL4 - killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Gene

KIR2DL4 - killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Gene

Homo sapiens

Also known as G9P; CD158D; KIR103; KIR-2DL4; KIR103AS; KIR-103AS

Gene ID: 3805 | Gene type: protein coding

About KIR2DL4

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,803,610-54,814,517 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 61 orthologues and 25 paralogues. Biased expression in spleen (RPKM 1.3), endometrium (RPKM 0.5) and 12 other tissues.

Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]

KIR2DL4 Products(3)

mRNA Protein Name
NM_001080770.2 NP_001074239.1 killer cell immunoglobulin-like receptor 2DL4 isoform c precursor
NM_001080772.2 NP_001074241.1 killer cell immunoglobulin-like receptor 2DL4 isoform b precursor
NM_002255.6 NP_002246.5 killer cell immunoglobulin-like receptor 2DL4 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables MHC class Ib receptor activity IDA
IDA: Inferred from direct assay
10190900 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16366734 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
10190900 GOA
involved in positive regulation of cellular senescence IDA
IDA: Inferred from direct assay
23184984 GOA
involved in positive regulation of natural killer cell cytokine production IDA
IDA: Inferred from direct assay
16366734 GOA
Cellular Component GO Annotation Evidence Reference Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
16366734 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIR2DL4 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (31 - 119)

Ig_2

Ig_2: Immunoglobulin domain (125 - 217)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
Protein Preferred Names Protein Names

killer cell immunoglobulin-like receptor 2DL4

CD158 antigen-like family member D

KIR2DL4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KIR2DL4 Q99706 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
KIR2DL4 Q99706 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
KIR2DL4 Q99706 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
KIR2DL4 Q99706 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra
KIR2DL4 Q99706 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra
KIR2DL4 Q99706 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
KIR2DL4 Q99706 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
KIR2DL4 Q99706 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra
KIR2DL4 Q99706 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra
KIR2DL4 Q99706 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KIR2DL4 Proteins

Cat. No. Product Name Accession Purity
HY-P7794 CD158d/KIR2DL4 Protein, Human (HEK293, His) ADY38409.1 (W22-H242) ≥95%

Related Diseases

Diseases Alias
Acute Diarrhea
Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome

Duane'S Syndrome

Duane Syndrome

Isolated Duane Retraction Syndrome

Co-Contractive Retraction Syndrome

Duane Anomaly, Isolated

Ocular Retraction Syndrome

Drs

Durs

Intussusception

Intussusception Of Intestine

Invagination Of Intestine Or Colon

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma