KRT13 - keratin 13 Gene

Homo sapiens

Also known as K13; CK13; WSN2

Gene ID: 3860 | Gene type: protein coding

About KRT13

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,500,981-41,505,612 (from NCBI)

This gene has 9 transcripts (splice variants), 30 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward esophagus (RPKM 15373.8).

Summary

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]

KRT13 Products(2)

mRNA	Protein	Name
NM_002274.4	NP_002265.3	keratin, type I cytoskeletal 13 isoform b
NM_153490.3	NP_705694.3	keratin, type I cytoskeletal 13 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	21371075	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular exosome	IDA IDA: Inferred from direct assay	21557262	GOA
located in intermediate filament cytoskeleton	IDA IDA: Inferred from direct assay	21371075	GOA
located in keratin filament	IDA IDA: Inferred from direct assay	9714826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT13 Protein Structure

Filament

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

keratin, type I cytoskeletal 13

CK-13

KRT13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KRT13	P13646	DES	Homo sapiens	P17661	Validated Y2H	32296183
Intra	KRT13	P13646	KRT72	Homo sapiens	Q14CN4	Validated Y2H	32296183
Intra	KRT13	P13646	KRT2	Homo sapiens	P35908	Y2H Array	31515488
Intra	KRT13	P13646	HOOK3	Homo sapiens	Q86VS8	Validated Y2H	32296183
Intra	KRT13	P13646	KRT4	Homo sapiens	P19013	Y2H Prey Pooling	32296183
Intra	KRT13	P13646	KRT4	Homo sapiens	P19013	Validated Y2H	32296183
Intra	KRT13	P13646	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	KRT13	P13646	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	KRT13	P13646	KRT6A	Homo sapiens	P02538	MAPPIT	32296183
Intra	KRT13	P13646	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	KRT13	P13646	GFAP	Homo sapiens	P14136	Validated Y2H	32296183
Intra	KRT13	P13646	GLYCTK	Homo sapiens	Q8IVS8	Validated Y2H	32296183
Intra	KRT13	P13646	KRT74	Homo sapiens	Q7RTS7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

White Sponge Nevus 2

WSN2

White Sponge Nevus 1

White Sponge Nevus Of Cannon	Leukokeratosis, Hereditary Mucosal
Hereditary Mucosal Leukokeratosis	White Sponge Nevus
WSN1	Wsn
Cannon'S Disease	Familial White Folded Mucosal Dysplasia
Hereditary Leukokeratosis	Hereditary Oral Keratosis
Leukokeratosis Of Oral Mucosa	Nevus Of Cannon
White Folded Gingivostomatosis	White Gingivostomatitis
White Sponge Naevus	White Sponge Nevus Of Mucosa

Inverted Papilloma

Inverted Papilloma, Squamous Cell	Papilloma Inverted
Papilloma, Inverted	Inverted Squamous Cell Papilloma

Cholesteatoma Of Middle Ear

Cholesteatoma	Epidermosis Of Ear
Epidermosis Of Middle Ear	Middle Ear Cholesteatoma
Cholesteatoma Of Middle Ear And Mastoid	Cholesteatoma Of Middle Ear And/Or Mastoid
Cholesteatoma Of The Middle Ear	Congenital Cholesteatoma
Primary Acquired Cholesteatoma	Secondary Acquired Cholesteatoma
Cholesteatoma Middle Ear	Cholesteatoma, Middle Ear
Cholesterolosis Of Middle Ear	Cholesterosis Of Ear
Cholesterosis Of Middle Ear	Cholesteatoma Nos
Epidermoid Cholesteatoma	Middle Ear Granuloma

Frontal Sinus Inverted Papilloma

Inverted Papilloma Of The Frontal Sinus

Papilloma

Papillomatosis

Leukoplakia

Leukoplakia Of Gingiva	Leukoplakia Of Oral Epithelium
Leucoplakia Of Oral Mucosa	Leukokeratosis Of Oral Mucosa

Frontal Sinus Benign Neoplasm

Neoplasm Of Frontal Sinus

Tumor Of The Frontal Sinus

Lichen Planus

Lichen Ruber Planus	Lichen, Ruber Planus
Ruber Planus	Lp - [Lichen Planus]
Lichen Planus Of Wilson	Wilson Lichen Ruber

Human Papillomavirus Infectious Disease

Hpv	Papillomavirus Infections
Human Papilloma Virus Infection

Thymic Carcinoma

Malignant Thymoma

Thymoma, Malignant

Transitional Papilloma

Transitional Cell Papilloma

Transitional Cell Papilloma, Benign

Ovarian Brenner Tumor

Benign Ovarian Brenner Tumor	Brenner Tumor
Benign Ovarian Brenner Tumour	Ovarian Brenner Tumour
Brenner Tumor Of Ovary	Benign Brenner Tumor

Mucoepidermoid Carcinoma

Mec	Salivary Gland Mucoepidermoid Carcinoma
C3772	Carcinoma Mucoepidermoid
Carcinoma, Mucoepidermoid

Vulva Cancer

Vulvar Carcinoma	Malignant Neoplasm Of Vulva
Vulva Carcinoma	Carcinoma Of Vulva
Vulvar Cancer	Vulval Cancer
Vulvar Neoplasms	Ca Vulva
Malignant Tumor Of Vulva	Malignant Vulvar Tumor
Neoplasm Of Vulva	Vulval Neoplasm
Vulvar Neoplasm	Vulvar Tumor
Cancer Of Vulva	Malignant Tumour Of Vulva

Keratitis, Hereditary

Keratitis	Autosomal Dominant Keratitis
Hereditary Keratitis	Dominantly Inherited Keratitis
Keratitis Hereditary	KERH

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Pigmented Basal Cell Carcinoma

Skin Pigmented Basal Cell Carcinoma

Skin Benign Neoplasm

Neoplasm Of Skin By Site	Tumor Of The Skin
Skin Tumor	Benign Neoplasm Of Skin
Skin Neoplasms

Lip And Oral Cavity Cancer

Oral Cancer	Lip And Oral Cavity Carcinoma
Malignant Neoplasm Of Mouth

Cicatricial Pemphigoid

Mucous Membrane Pemphigoid	Ocular Pemphigoid
Benign Mucous Membrane Pemphigoid	Benign Mucous Membrane Pemphigoid With Ocular Involvement
Benign Mucosal Pemphigoid	Pemphigoid, Benign Mucous Membrane
Cicatricial Pemphigoid With Ocular Involvement	Ocular Pemphigus
Cicatricial Pemphigoid Disease	Mucosal Pemphigoid
Mucosynechial Pemphigoid	Pemphigoid Cicatricial
Cicatricial Pemphigoid Involving The Eye	Ocular Cicatricial Pemphigoid

Cortical Thymoma

Polygonal Cell Thymoma	Thymoma, Cortical
Thymoma, Type B2

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

Eec Syndrome	Rudiger Syndrome 1
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1	EEC1
Eec Syndrome 1	Eec Syndrome-1
Walker-Clodius Syndrome	Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome
Eec	Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome
Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome	Ectrodactyly-Cleft Lip/Palate Syndrome
Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate	Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome
Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome	Ectrodactyly-Cleft Lip-Palate Syndrome
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome

Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex

Exstrophy-Epispadias Complex	Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex
Beec	Eec
Exstrophy Of The Bladder	Bladder Exstrophy
Bladder Exstrophy And Epispadias Complex

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Bladder Exstrophy

Exstrophy Of The Bladder

Classic Exstrophy Of The Bladder

Severe Cutaneous Adverse Reaction

Stevens-Johnson Syndrome	Toxic Epidermal Necrolysis
Drug-Induced Stevens Johnson Syndrome	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Susceptibility To Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Lyell'S Syndrome	Lyell Syndrome
Severe Cutaneous Adverse Reaction, Susceptibility To	Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To
Hypersensitivity Syndrome, Carbamazepine-Induced	Stevens-Johnson Syndrome, Susceptibility To
Toxic Epidermal Necrolysis, Susceptibility To	Sjs/Ten
Susceptibility To Severe Cutaneous Adverse Reaction Ity To	Mycoplasma-Induced Stevens Johnson Syndrome
Dermatostomatitis, Stevens Johnson Type	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Sjs-Ten	Toxic Epidermolysis
SJS	Dermatostomatitis Stevens Johnson Type
Ten	Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis]
Ten - [Toxic Epidermal Necrolysis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07436	KRT13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT13	MGD	MGI:101925
Canis familiaris	KRT13	VGNC	VGNC:55619
Rattus norvegicus	KRT13	RGD	RGD:1302937

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