2. Gene
  3. KRT4 - keratin 4 Gene

KRT4 - keratin 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as K4; CK4; CK-4; CYK4; WSN1

Gene ID: 3851 | Gene type: protein coding

About KRT4

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,806,549-52,814,116 (from NCBI)

This gene has 5 transcripts (splice variants), 96 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward esophagus (RPKM 10134.3).

Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

KRT4 Products(1)

mRNA Protein Name
NM_002272.4 NP_002263.3 keratin, type II cytoskeletal 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17709412 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21371075 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
17709412 GOA
located in intermediate filament cytoskeleton IDA
IDA: Inferred from direct assay
21371075 GOA
located in keratin filament IDA
IDA: Inferred from direct assay
21371075 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT4 Protein Structure

Filament

Filament: Intermediate filament protein (210 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 4

cytokeratin 4

KRT4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra KRT4 P19013 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra KRT4 P19013 KRT13 Homo sapiens A1A4E9
Y2H Array
25416956
Intra KRT4 P19013 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra KRT4 P19013 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra KRT4 P19013 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT40 Homo sapiens Q6A162
Y2H Array
31515488
Intra KRT4 P19013 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra KRT4 P19013 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra KRT4 P19013 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra KRT4 P19013 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT37 Homo sapiens O76014
Y2H Array
32296183
Intra KRT4 P19013 KRT38 Homo sapiens O76015
Y2H Array
31515488
Intra KRT4 P19013 KRT38 Homo sapiens O76015
Validated Y2H
25416956
Intra KRT4 P19013 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT38 Homo sapiens O76015
Y2H Array
25416956
Intra KRT4 P19013 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra KRT4 P19013 KRT38 Homo sapiens O76015
Y2H Array
29892012
Intra KRT4 P19013 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra KRT4 P19013 KRT33B Homo sapiens Q14525
Y2H Array
25416956
Intra KRT4 P19013 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra KRT4 P19013 KRT33B Homo sapiens Q14525
Y2H Array
31515488
Intra KRT4 P19013 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
25416956
Intra KRT4 P19013 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra KRT4 P19013 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra KRT4 P19013 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Intra KRT4 P19013 TUBGCP4 Homo sapiens Q9UGJ1-2
Validated Y2H
32296183
Intra KRT4 P19013 TUBGCP4 Homo sapiens Q9UGJ1-2
Y2H Array
32296183
Intra KRT4 P19013 TUBGCP4 Homo sapiens Q9UGJ1-2
Y2H Prey Pooling
32296183
Intra KRT4 P19013 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra KRT4 P19013 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra KRT4 P19013 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra KRT4 P19013 CEP57 Homo sapiens Q86XR8-3
Validated Y2H
32296183
Intra KRT4 P19013 CEP57 Homo sapiens Q86XR8-3
Y2H Array
32296183
Intra KRT4 P19013 CEP57 Homo sapiens Q86XR8-3
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra KRT4 P19013 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
Intra KRT4 P19013 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
Intra KRT4 P19013 KRT28 Homo sapiens Q7Z3Y7
Validated Y2H
32296183
Intra KRT4 P19013 KRT28 Homo sapiens Q7Z3Y7
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT28 Homo sapiens Q7Z3Y7
Y2H Array
32296183
Intra KRT4 P19013 KRT13 Homo sapiens P13646
Y2H Array
31515488
Intra KRT4 P19013 KRT13 Homo sapiens P13646
Y2H Array
32296183
Intra KRT4 P19013 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra KRT4 P19013 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra KRT4 P19013 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra KRT4 P19013 KRT24 Homo sapiens Q2M2I5
Validated Y2H
32296183
Intra KRT4 P19013 KRT24 Homo sapiens Q2M2I5
Y2H Array
32296183
Intra KRT4 P19013 KRT24 Homo sapiens Q2M2I5
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra KRT4 P19013 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra KRT4 P19013 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra KRT4 P19013 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra KRT4 P19013 NUMA1 Homo sapiens Q14980
Anti Tag CoIP
33961781
Intra KRT4 P19013 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra KRT4 P19013 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra KRT4 P19013 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra KRT4 P19013 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra KRT4 P19013 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra KRT4 P19013 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra KRT4 P19013 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra KRT4 P19013 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Cross KRT4 P19013 tax Human T-cell leukemia virus 1 P14079
Y2H Pooling
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
White Sponge Nevus 1

White Sponge Nevus Of Cannon

Leukokeratosis, Hereditary Mucosal

Hereditary Mucosal Leukokeratosis

White Sponge Nevus

WSN1

Wsn

Cannon'S Disease

Familial White Folded Mucosal Dysplasia

Hereditary Leukokeratosis

Hereditary Oral Keratosis

Leukokeratosis Of Oral Mucosa

Nevus Of Cannon

White Folded Gingivostomatosis

White Gingivostomatitis

White Sponge Naevus

White Sponge Nevus Of Mucosa
Leukoplakia

Leukoplakia Of Gingiva

Leukoplakia Of Oral Epithelium

Leucoplakia Of Oral Mucosa

Leukokeratosis Of Oral Mucosa
Epidermolysis Bullosa Simplex 2f, With Mottled Pigmentation

Epidermolysis Bullosa Simplex With Mottled Pigmentation

Ebsmp

Speckled Hyperpigmentation With Punctate Palmoplantar Keratoses And Childhood Blistering

Ebs-Mp

EBS2F

Ebs With Mottled Pigmentation

Epidermolysis Bullosa Simplex-Mp

Speckled Hyperpigmentation, Palmo-Plantar Punctate Keratoses And Childhood Blistering

Epidermolysis Bullosa Simplex, With Mottled Pigmentation
Epidermolysis Bullosa Simplex 1a, Generalized Severe

Epidermolysis Bullosa Simplex, Dowling-Meara Type

Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type

EBS1A

Ebsdm

Epidermolysis Bullosa Simplex Dowling-Meara Type

Epidermolysis Bullosa Simplex, Herpetiformis

Ebs-Dm

Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type

Ebs-Gen Sev

Epidermolysis Bullosa Herpetiformis Dowling-Meara Type

Generalized Severe Epidermolysis Bullosa Simplex

Dowling-Meara Type Epidermolysis Bullosa Simplex

Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form

Autosomal Dominant Generalized Ebs, Severe Form

Epidermolysis Bullosa Simplex Herpetiformis

Dm-Ebs

Epidermolysis Bullosa Simplex, Generalized Severe

Epidermolysis Bullosa Herpetiformis, Dowling-Meara

Epidermolysis Bullosa Herpetiformis Dowling-Meara
Hairy Tongue

Overgrowth Of Filiform Papillae

Tongue, Hairy
Dowling-Degos Disease

Reticular Pigment Anomaly Of Flexures

Dark Dot Disease

Reticulate Acropigmentation Of Kitamura

Dowling-Degos Kitamura Disease

Kitamura Reticulate Acropigmentation

Ddd

Dowling-Degos-Kitamura Disease

Reticular Pigmented Anomaly Of Flexures
Reticulate Acropigmentation Of Kitamura

RAK

Acropigmentatio Reticularis

Reticulate Pigmentation Of Kitamura

Rpk

Kitamura Reticulate Acropigmentation

Rapk
Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma

EHK

Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

Bcie

Bie

Epidermolytic Ichthyosis

Ichthyosis Bullosa Of Siemens

Superficial Epidermolytic Ichthyosis

Hyperkeratosis, Epidermolytic

Congenital Bullous Ichthyosiform Erythroderma

Bullous Type Ichthyosis

Epidermolytic Palmoplantar Hyperkeratosis

Bullous Ichthyosiform Erythroderma Congenita

Bullous Erythroderma Ichthyosiforme

Sei

Epidermolytic Hyperkeratosis Late-Onset

Epidermolytic Hyperkeratosis, Late-Onset
Epidermolysis Bullosa Simplex Localized Type

Epidermolysis Bullosa Simplex, Weber-Cockayne Type

Weber-Cockayne Syndrome

Ebs-Loc

Epidermolysis Bullosa Simplex Of Palms And Soles

Epidermolysis Bullosa Simplex Weber-Cockayne Type

Epidermolysis Bullosa Simplex, Localized

Epidermolysis Bullosa Of Hands And Feet

Weber-Cockayne Type Epidermolysis Bullosa Simplex

Localized Epidermolysis Bullosa Simplex

Localized Ebs
Prostate Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Prostate
Ichthyosis, Congenital, Autosomal Recessive 2

Autosomal Recessive Congenital Ichthyosis 2

ARCI2

Ncie1

Ichthyosiform Erythroderma, Congenital

Collodion Baby, Self-Healing

Ichthyosiform Erythroderma, Nonbullous Congenital, 1, Formerly

Ncie1, Formerly

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form, Formerly

Brocq Congenital Ichthyosiform Erythroderma Nonbullous Form

Nonbullous Congenital Ichthyosiform Erythroderma 1

Cie

Ichthyosiform Erythroderma Brocq Congenital Non-Bullous Form

Iecn1

Non-Bullous Congenital Ichthyosiform Erythroderma Type 1

Self-Healing Collodion Baby

Ichthyosis, Congenital, Autosomal Recessive, Type 2

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2
Cloacogenic Carcinoma

Cloacogenic Anal Carcinoma
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Epidermolysis Bullosa Dystrophica

Dystrophic Epidermolysis Bullosa

Deb

Dermolytic Epidermolysis Bullosa

Epidermolysis Bullosa, Dermolytic

Epidermolysis Bullosa, Dystrophic

Epidermolysis Bullosa Dystrophic

Dystrophic Eb - [Epidermolysis Bullosa]
Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa
Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma

EPPK

Keratosis Palmaris Et Plantaris Familiaris

Tylosis

Keratosis Of Greither

Diffuse Nonepidermolytic Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Epidermolytic

Unna-Thost Palmoplantar Keratoderma

Epidermolytic Palmoplantar Keratoderma Of Voerner

Ppke

Keratoderma, Epidermolytic Palmoplantar

Palmoplantar Keratoderma, Vorner Type

Hyperkeratosis, Localized Epidermolytic

Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

Epidermolytic Palmoplantar Keratoderma Of Vörner

Hyperkeratosis Palmoplantar Localized Epidermolytic

Diffuse Neppk

Ppk Diffusa Circumscripta

Thost-Unna Disease

Thost-Unna Palmoplantar Keratoderma

Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

Epidermolytic Palmoplantar Keratoderma Of Vorner

Ehppk

Epidermolytic Unna-Thost Disease

Localized Epidermolytic Hyperkeratosis

Palmoplantar Keratoderma Vorner Type

Unilateral Palmoplantar Verrucous Nevus

UPVN

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis

Palmoplantar Keratoderma, Nonepidermolytic

Epidermolytic Palmoplantar Keratoderma Vorner Type

Type B Tylosis

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Type A Tylosis
Bullous Skin Disease

Skin Diseases Bullous

Skin Diseases, Bullous
Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional

Jeb

Epidermolysis Bullosa Atrophicans

Congenital Junctional Epidermolysis Bullosa

Epidermolysis Bullosa Junctional

Junctional Eb - [Epidermolysis Bullosa]

Jeb - [Junctional Epidermolysis Bullosa]

Lucidolytic Epidermolysis Bullosa
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07455 KRT4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KRT4 VGNC VGNC:30732
Rattus norvegicus KRT4 RGD RGD:1359272
Felis catus KRT4 VGNC VGNC:67990
Mus musculus KRT4 MGD MGI:96701
Macaca mulatta KRT4 VGNC VGNC:100070