KRT74 - keratin 74 Gene

Homo sapiens (human)

Also known as ADWH; ECTD7; HTSS2; HYPT3; KRT5C; K6IRS4; KRT6IRS4

Gene ID: 121391 | Gene type: protein coding

About KRT74

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

KRT74 Products(1)

mRNA	Protein	Name
NM_175053.4	NP_778223.2	keratin, type II cytoskeletal 74

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables keratin filament binding	IPI IPI: Inferred from physical interaction	20346438	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intermediate filament cytoskeleton organization	IDA IDA: Inferred from direct assay	20346438	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20346438	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

keratin, type II cytoskeletal 74

CK-74	K5C
K74	cytokeratin-74
keratin 5c	keratin 6 irs4
keratin 74, type II	type II inner root sheath-specific keratin-K6irs4
type-II keratin Kb37

KRT74 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KRT74	Q7RTS7	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT37	Homo sapiens	O76014	MAPPIT	32296183
Intra	KRT74	Q7RTS7	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT74	Q7RTS7	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT74	Q7RTS7	KRT26	Homo sapiens	Q7Z3Y9	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT26	Homo sapiens	Q7Z3Y9	Validated Y2H	32296183
Intra	KRT74	Q7RTS7	KRT26	Homo sapiens	Q7Z3Y9	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT13	Homo sapiens	P13646	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT13	Homo sapiens	P13646	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT74	Q7RTS7	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT74	Q7RTS7	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KRT74	Q7RTS7	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

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