2. Gene
  3. KRT2 - keratin 2 Gene

KRT2 - keratin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as K2e; KRTE; CK-2e; KRT2A; KRT2E

Gene ID: 3849 | Gene type: protein coding

About KRT2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,644,558-52,652,211 (from NCBI)

This gene has 2 transcripts (splice variants), 78 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward skin (RPKM 1015.4).

Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

KRT2 Products(1)

mRNA Protein Name
NM_000423.3 NP_000414.2 keratin, type II cytoskeletal 2 epidermal
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables structural constituent of skin epidermis IDA
IDA: Inferred from direct assay
7543090 GOA
Biological Process GO Annotation Evidence Reference Source
involved in keratinization IDA
IDA: Inferred from direct assay
12598329 GOA
involved in keratinocyte activation IDA
IDA: Inferred from direct assay
12598329 GOA
involved in keratinocyte migration IDA
IDA: Inferred from direct assay
15737202 GOA
involved in keratinocyte proliferation IDA
IDA: Inferred from direct assay
12598329 GOA
involved in peptide cross-linking IDA
IDA: Inferred from direct assay
7543090 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cornified envelope IDA
IDA: Inferred from direct assay
7543090 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
32179842 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT2 Protein Structure

Filament

Filament: Intermediate filament protein (177 - 490)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 639 a.a.
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 2 epidermal

cytokeratin-2e

KRT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KRT2 P35908 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
KRT2 P35908 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT40 Homo sapiens Q6A162
Validated Y2H
25910212
Intra
KRT2 P35908 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
KRT2 P35908 KRT40 Homo sapiens Q6A162
Y2H Array
25910212
Intra
KRT2 P35908 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
KRT2 P35908 KRT40 Homo sapiens Q6A162
Y2H Bait-Prey Pool
25910212
Intra
KRT2 P35908 KRT40 Homo sapiens Q6A162
SLC
25910212
Intra
KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Array
25910212
Intra
KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Array
25416956
Intra
KRT2 P35908 KRT38 Homo sapiens O76015
Validated Y2H
25910212
Intra
KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Array
29892012
Intra
KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Bait-Prey Pool
25910212
Intra
KRT2 P35908 KRT38 Homo sapiens O76015
SLC
25910212
Intra
KRT2 P35908 KRT38 Homo sapiens O76015
Y2H Array
31515488
Intra
KRT2 P35908 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra
KRT2 P35908 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
KRT2 P35908 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
KRT2 P35908 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
KRT2 P35908 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
KRT2 P35908 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
Intra
KRT2 P35908 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
Intra
KRT2 P35908 KRT13 Homo sapiens P13646
Y2H Array
31515488
Intra
KRT2 P35908 KRT13 Homo sapiens P13646
Y2H Bait-Prey Pool
25910212
Intra
KRT2 P35908 KRT13 Homo sapiens P13646
Validated Y2H
25910212
Intra
KRT2 P35908 KRT13 Homo sapiens P13646
Y2H Array
25910212
Intra
KRT2 P35908 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
KRT2 P35908 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
KRT2 P35908 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra
KRT2 P35908 KRT15 Homo sapiens P19012
Y2H Bait-Prey Pool
25910212
Intra
KRT2 P35908 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra
KRT2 P35908 KRT15 Homo sapiens P19012
SLC
25910212
Intra
KRT2 P35908 KRT15 Homo sapiens P19012
Validated Y2H
25910212
Intra
KRT2 P35908 KRT15 Homo sapiens P19012
Y2H Array
25910212
Intra
KRT2 P35908 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT19 Homo sapiens P08727
Validated Y2H
25910212
Intra
KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Array
25910212
Intra
KRT2 P35908 KRT19 Homo sapiens P08727
Validated Y2H
25416956
Intra
KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Array
25416956
Intra
KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Bait-Prey Pool
25910212
Intra
KRT2 P35908 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
Validated Y2H
25910212
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Bait-Prey Pool
25910212
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Array
25910212
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
KRT2 P35908 KRT31 Homo sapiens Q15323
SLC
25910212
Cross: Cross-species interaction Intra: Intraspecies interaction

KRT2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82926 Cytokeratin 2e Antibody (YA2671) WB, IHC-P Human

Related Diseases

Diseases Alias
Ichthyosis Bullosa Of Siemens

IBS

Ichthyosis, Bullous Type

Bullous Type Of Ichthyosis

Ichthyosis Bullous Type
Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma

EHK

Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

Bcie

Bie

Epidermolytic Ichthyosis

Ichthyosis Bullosa Of Siemens

Superficial Epidermolytic Ichthyosis

Hyperkeratosis, Epidermolytic

Congenital Bullous Ichthyosiform Erythroderma

Bullous Type Ichthyosis

Epidermolytic Palmoplantar Hyperkeratosis

Bullous Ichthyosiform Erythroderma Congenita

Bullous Erythroderma Ichthyosiforme

Sei

Epidermolytic Hyperkeratosis Late-Onset

Epidermolytic Hyperkeratosis, Late-Onset
Exfoliative Ichthyosis

Ichthyosis Exfoliativa

Autosomal Recessive Exfoliative Ichthyosis
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Epidermolytic Acanthoma
Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma

EPPK

Keratosis Palmaris Et Plantaris Familiaris

Tylosis

Keratosis Of Greither

Diffuse Nonepidermolytic Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Epidermolytic

Unna-Thost Palmoplantar Keratoderma

Epidermolytic Palmoplantar Keratoderma Of Voerner

Ppke

Keratoderma, Epidermolytic Palmoplantar

Palmoplantar Keratoderma, Vorner Type

Hyperkeratosis, Localized Epidermolytic

Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

Epidermolytic Palmoplantar Keratoderma Of Vörner

Hyperkeratosis Palmoplantar Localized Epidermolytic

Diffuse Neppk

Ppk Diffusa Circumscripta

Thost-Unna Disease

Thost-Unna Palmoplantar Keratoderma

Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

Epidermolytic Palmoplantar Keratoderma Of Vorner

Ehppk

Epidermolytic Unna-Thost Disease

Localized Epidermolytic Hyperkeratosis

Palmoplantar Keratoderma Vorner Type

Unilateral Palmoplantar Verrucous Nevus

UPVN

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis

Palmoplantar Keratoderma, Nonepidermolytic

Epidermolytic Palmoplantar Keratoderma Vorner Type

Type B Tylosis

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Type A Tylosis
White Sponge Nevus 1

White Sponge Nevus Of Cannon

Leukokeratosis, Hereditary Mucosal

Hereditary Mucosal Leukokeratosis

White Sponge Nevus

WSN1

Wsn

Cannon'S Disease

Familial White Folded Mucosal Dysplasia

Hereditary Leukokeratosis

Hereditary Oral Keratosis

Leukokeratosis Of Oral Mucosa

Nevus Of Cannon

White Folded Gingivostomatosis

White Gingivostomatitis

White Sponge Naevus

White Sponge Nevus Of Mucosa
Steatocystoma Multiplex

Sebocystomatosis

Multiple Sebaceous Cysts

Multiplex Steatocystoma

Sebaceous Cysts, Multiple

SM
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma

Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma

FNEPPK1

Ppkfne

Keratoderma, Focal Nonepidermolytic Palmoplantar

Palmoplantar Keratoderma, Nonepidermolytic, Focal

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Fneppk

Focal Nonepidermolytic Palmoplantar Keratoderma 1

Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1

Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Monilethrix

Beaded Hair

MNLIX

Nodose Hair

Moniliform Hair Syndrome
Nevus, Epidermal

Epidermal Nevus

Woolly Hair Nevus

Epidermal Naevus

Epidermal Nevus Syndrome

Nevus, Keratinocytic, Nonepidermolytic

Epidermal Nevus, Somatic

Nevus, Epidermal, Somatic

Nevus Sebaceous Or Woolly Hair Nevus, Somatic

Nonepidermolytic Keratinocytic Nevus

Epidermal Hamartoma Syndrome

Wooly Hair Nevus

Keratinocytic Non-Epidermolytic Nevus

KNEN

Pigmented Moles

Organoid Nevus Phakomatosis

Nevus Sebaceous

Melanocytic Nevus

Melanocytic Nevus Of Skin
Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa
Dowling-Degos Disease

Reticular Pigment Anomaly Of Flexures

Dark Dot Disease

Reticulate Acropigmentation Of Kitamura

Dowling-Degos Kitamura Disease

Kitamura Reticulate Acropigmentation

Ddd

Dowling-Degos-Kitamura Disease

Reticular Pigmented Anomaly Of Flexures
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07443 KRT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KRT2 VGNC VGNC:30721
Mus musculus KRT2 MGD MGI:96699
Rattus norvegicus KRT2 RGD RGD:1303297
Canis familiaris KRT2 VGNC VGNC:42520
Macaca mulatta KRT2 VGNC VGNC:74212