LAMTOR4 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Gene

Homo sapiens

Also known as C7orf59

Gene ID: 389541 | Gene type: protein coding

About LAMTOR4

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,148,918-100,154,203 (from NCBI)

This gene has 12 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in skin (RPKM 36.0), spleen (RPKM 29.2) and 25 other tissues.

Summary

Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TOR signaling; and protein localization to lysosome. Located in lysosome. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]

LAMTOR4 Products(6)

mRNA	Protein	Name
NM_001008395.4	NP_001008396.1	ragulator complex protein LAMTOR4 isoform 1
NM_001318236.2	NP_001305165.1	ragulator complex protein LAMTOR4 isoform 2
NM_001318237.2	NP_001305166.1	ragulator complex protein LAMTOR4 isoform 3
NM_001394587.1	NP_001381516.1	ragulator complex protein LAMTOR4 isoform 4
NM_001394588.1	NP_001381517.1	ragulator complex protein LAMTOR4 isoform 5
NM_001394589.1	NP_001381518.1	ragulator complex protein LAMTOR4 isoform 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	22980980	GOA
contributes to molecular adaptor activity	IDA IDA: Inferred from direct assay	22980980	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22980980	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	22980980	GOA
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	22980980	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	22980980	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	28935770	GOA
involved in protein localization to lysosome	IMP IMP: Inferred from mutant phenotype	22980980	GOA
involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	22980980	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FNIP-folliculin RagC/D GAP	IDA IDA: Inferred from direct assay	36103527	GOA
part of Ragulator complex	IDA IDA: Inferred from direct assay	22980980	GOA
part of Ragulator complex	IPI IPI: Inferred from physical interaction	28935770	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	29158492	GOA
located in lysosome	IDA IDA: Inferred from direct assay	22980980	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ragulator complex protein LAMTOR4

UPF0539 protein C7orf59

LAMTOR4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Anti Tag CoIP	25561175
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	X-Ray Diffraction	29123114
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Y2H Prey Pooling	25416956
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Light Scattering	29123114
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Affinity Chrom	22980980
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Anti Tag CoIP	33961781
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Validated Y2H	25416956
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Y2H Prey Pooling	32296183
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Y2H Array	25416956
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Y2H Fragment Pooling	23414517
Intra	LAMTOR4	Q0VGL1	LAMTOR5	Homo sapiens	O43504	Y2H Array	32296183
Intra	LAMTOR4	Q0VGL1	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	25561175
Intra	LAMTOR4	Q0VGL1	LAMTOR1	Homo sapiens	Q6IAA8	Confocal	22980980
Intra	LAMTOR4	Q0VGL1	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	22980980
Intra	LAMTOR4	Q0VGL1	LAMTOR1	Homo sapiens	Q6IAA8	BRET	37398436
Intra	LAMTOR4	Q0VGL1	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	33961781
Intra	LAMTOR4	Q0VGL1	LAMTOR1	Homo sapiens	Q6IAA8	Affinity Chrom	22980980
Intra	LAMTOR4	Q0VGL1	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	33961781
Intra	LAMTOR4	Q0VGL1	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25561175

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Newfoundland Rod-Cone Dystrophy

Newfoundland Cone-Rod Dystrophy	NFRCD
Rod-Cone Dystrophy Newfoundland

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07516	LAMTOR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LAMTOR4	VGNC	VGNC:74178
Canis familiaris	LAMTOR4	VGNC	VGNC:42579
Felis catus	LAMTOR4	VGNC	VGNC:80588
Mus musculus	LAMTOR4	MGD	MGI:1913346
Bos taurus	LAMTOR4	VGNC	VGNC:30782
Rattus norvegicus	LAMTOR4	RGD	RGD:1309735

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