LAMTOR5 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Gene

Homo sapiens

Also known as XIP; HBXIP

Gene ID: 10542 | Gene type: protein coding

About LAMTOR5

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,401,253-110,407,924 (from NCBI)

This gene has 7 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in kidney (RPKM 162.7), bone marrow (RPKM 53.1) and 24 other tissues.

Summary

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

LAMTOR5 Products(2)

mRNA	Protein	Name
NM_001382293.1	NP_001369222.1	ragulator complex protein LAMTOR5 isoform 2
NM_006402.3	NP_006393.2	ragulator complex protein LAMTOR5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	22980980	GOA
contributes to molecular adaptor activity	IDA IDA: Inferred from direct assay	22980980	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12773388	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	22980980	GOA
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	22980980	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12773388	GOA
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IGI IGI: Inferred from genetic interaction	21343296	GOA
acts upstream of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21343296	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	22980980	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	28935770	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	21343296	GOA
acts upstream of positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	21343296	GOA
involved in positive regulation of interleukin-8 production	IGI IGI: Inferred from genetic interaction	21343296	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	21343296	GOA
involved in protein localization to lysosome	IMP IMP: Inferred from mutant phenotype	22980980	GOA
involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	22980980	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FNIP-folliculin RagC/D GAP	IDA IDA: Inferred from direct assay	36103527	GOA
part of Ragulator complex	IDA IDA: Inferred from direct assay	22980980	GOA
part of Ragulator complex	IPI IPI: Inferred from physical interaction	28935770	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12773388	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	29158492	GOA
located in lysosome	IDA IDA: Inferred from direct assay	22980980	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	12773388	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ragulator complex protein LAMTOR5

HBV X-interacting protein

LAMTOR5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LAMTOR5	O43504	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	LAMTOR5	O43504	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	LAMTOR5	O43504	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	LAMTOR5	O43504	SARS1	Homo sapiens	P49591	Validated Y2H	32814053
Intra	LAMTOR5	O43504	SARS1	Homo sapiens	P49591	Y2H Pooling	32814053
Intra	LAMTOR5	O43504	SARS1	Homo sapiens	P49591	Y2H Array	32814053
Intra	LAMTOR5	O43504	AK6	Homo sapiens	Q9Y3D8	Y2H Array	25416956
Intra	LAMTOR5	O43504	AK6	Homo sapiens	Q9Y3D8	Y2H Prey Pooling	25416956
Intra	LAMTOR5	O43504	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	LAMTOR5	O43504	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	LAMTOR5	O43504	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	LAMTOR5	O43504	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	LAMTOR5	O43504	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	LAMTOR5	O43504	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	LAMTOR5	O43504	HSPA2	Homo sapiens	P54652	Validated Y2H	32814053
Intra	LAMTOR5	O43504	HSPA2	Homo sapiens	P54652	Y2H Array	32814053
Intra	LAMTOR5	O43504	HSPA2	Homo sapiens	P54652	Y2H Pooling	32814053
Intra	LAMTOR5	O43504	BIRC5	Homo sapiens	O15392	Validated Y2H	32296183
Intra	LAMTOR5	O43504	LAMTOR4	Homo sapiens	Q0VGL1	Y2H Prey Pooling	32296183
Intra	LAMTOR5	O43504	LAMTOR4	Homo sapiens	Q0VGL1	Anti Tag CoIP	33961781
Intra	LAMTOR5	O43504	LAMTOR4	Homo sapiens	Q0VGL1	MAPPIT	32296183
Intra	LAMTOR5	O43504	LAMTOR4	Homo sapiens	Q0VGL1	Validated Y2H	32296183
Intra	LAMTOR5	O43504	LAMTOR4	Homo sapiens	Q0VGL1	Affinity Chrom	22980980
Intra	LAMTOR5	O43504	LAMTOR4	Homo sapiens	Q0VGL1	Y2H Array	32296183
Intra	LAMTOR5	O43504	LAMTOR4	Homo sapiens	Q0VGL1	Anti Tag CoIP	25561175
Intra	LAMTOR5	O43504	ZBTB16	Homo sapiens	Q05516	Y2H Prey Pooling	32296183
Intra	LAMTOR5	O43504	ZBTB16	Homo sapiens	Q05516	Validated Y2H	32296183
Intra	LAMTOR5	O43504	ZBTB16	Homo sapiens	Q05516	Y2H Array	25416956
Intra	LAMTOR5	O43504	ZBTB16	Homo sapiens	Q05516	Y2H Pooling	16169070
Intra	LAMTOR5	O43504	ZBTB16	Homo sapiens	Q05516	Y2H Array	32296183
Intra	LAMTOR5	O43504	ZBTB16	Homo sapiens	Q05516	Y2H Fragment Pooling	23414517
Intra	LAMTOR5	O43504	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	LAMTOR5	O43504	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	LAMTOR5	O43504	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	LAMTOR5	O43504	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	LAMTOR5	O43504	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	LAMTOR5	O43504	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	LAMTOR5	O43504	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	LAMTOR5	O43504	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	LAMTOR5	O43504	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	LAMTOR5	O43504	TCAP	Homo sapiens	O15273	Y2H Fragment Pooling	23414517
Intra	LAMTOR5	O43504	TCAP	Homo sapiens	O15273	Validated Y2H	32296183
Intra	LAMTOR5	O43504	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	33961781
Intra	LAMTOR5	O43504	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25561175
Cross	LAMTOR5	O43504	Q9WMX2-PRO_0000037547	Hepatitis C virus	Q9WMX2-PRO_0000037547	Pull Down	24169621

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Lobomycosis

Cutaneous Blastomycosis	Cutaneous Lobomycosis
Infection By Loboa Loboi	Lobo Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07517	LAMTOR5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LAMTOR5	RGD	RGD:1305005
Felis catus	LAMTOR5	VGNC	VGNC:82532
Bos taurus	LAMTOR5	VGNC	VGNC:55244
Mus musculus	LAMTOR5	MGD	MGI:1915826

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