2. Gene
  3. LGALS8 - galectin 8 Gene

LGALS8 - galectin 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Gal-8; PCTA1; PCTA-1; Po66-CBP

Gene ID: 3964 | Gene type: protein coding

About LGALS8

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:236,518,214-236,552,981 (from NCBI)

This gene has 28 transcripts (splice variants), 279 orthologues and 16 paralogues. Ubiquitous expression in spleen (RPKM 17.5), skin (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a member of the Galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, Apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

LGALS8 Products(4)

mRNA Protein Name
NM_006499.5 NP_006490.3 galectin-8 isoform a
NM_201543.4 NP_963837.1 galectin-8 isoform b
NM_201544.4 NP_963838.1 galectin-8 isoform b
NM_201545.2 NP_963839.1 galectin-8 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables carbohydrate binding IDA
IDA: Inferred from direct assay
22246324 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
19268462 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
28077878 GOA
involved in lymphatic endothelial cell migration IDA
IDA: Inferred from direct assay
19268462 GOA
involved in xenophagy IMP
IMP: Inferred from mutant phenotype
22246324 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19268462 GOA
located in cytosol IDA
IDA: Inferred from direct assay
22246324 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGALS8 Protein Structure

Gal-bind_lectin

Gal-bind_lectin: Galactoside-binding lectin (18 - 150)

Gal-bind_lectin

Gal-bind_lectin: Galactoside-binding lectin (186 - 314)

  • 0
  • 100
  • 200
  • 317 a.a.
Protein Preferred Names Protein Names

galectin-8

Po66 carbohydrate binding protein

LGALS8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LGALS8 O00214 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
Intra
LGALS8 O00214 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
Intra
LGALS8 O00214 TAX1BP1 Homo sapiens Q86VP1
Anti Tag CoIP
33961781
Intra
LGALS8 O00214 TGIF1 Homo sapiens Q15583
IF
18511908
Intra
LGALS8 O00214 TGIF1 Homo sapiens Q15583
Anti Bait CoIP
18511908
Intra
LGALS8 O00214 TGIF1 Homo sapiens Q15583
Anti Tag CoIP
18511908
Intra
LGALS8 O00214 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
LGALS8 O00214 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
LGALS8 O00214 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
LGALS8 O00214 APEH Homo sapiens P13798
Validated Y2H
25416956
Intra
LGALS8 O00214 APEH Homo sapiens P13798
Y2H Array
31515488
Intra
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Y2H Pooling
16189514
Intra
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Anti Tag CoIP
33961781
Intra
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Y2H Array
31515488
Intra
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Anti Tag CoIP
28514442
Intra
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra
LGALS8 O00214 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra
LGALS8 O00214 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LGALS8 Proteins

Cat. No. Product Name Accession Purity
HY-P70190 Galectin-8/LGALS8 Protein, Human O00214-1 (M1-W317) ≥95%
HY-P700081AF Animal-Free Galectin-8/LGALS8 Protein, Human (His) O00214-1 (M2-W317) ≥95%
HY-P700382 Galectin-8/LGALS8 Protein, Human (GST) O00214-1 (M1-W317) ≥95%

Related Diseases

Diseases Alias
Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia
Cholesteatoma Of Middle Ear

Cholesteatoma

Epidermosis Of Ear

Epidermosis Of Middle Ear

Middle Ear Cholesteatoma

Cholesteatoma Of Middle Ear And Mastoid

Cholesteatoma Of Middle Ear And/Or Mastoid

Cholesteatoma Of The Middle Ear

Congenital Cholesteatoma

Primary Acquired Cholesteatoma

Secondary Acquired Cholesteatoma

Cholesteatoma Middle Ear

Cholesteatoma, Middle Ear

Cholesterolosis Of Middle Ear

Cholesterosis Of Ear

Cholesterosis Of Middle Ear

Cholesteatoma Nos

Epidermoid Cholesteatoma

Middle Ear Granuloma
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07609 LGALS8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LGALS8 RGD RGD:621272
Macaca mulatta LGALS8 VGNC VGNC:74258
Canis familiaris LGALS8 VGNC VGNC:42650
Bos taurus LGALS8 VGNC VGNC:30855
Mus musculus LGALS8 MGD MGI:1928481
Others LGALS8 NCBI