ARNT - aryl hydrocarbon receptor nuclear translocator Gene

Homo sapiens

Also known as HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta

Gene ID: 405 | Gene type: protein coding

About ARNT

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,809,713-150,876,599 (from NCBI)

This gene has 12 transcripts (splice variants), 212 orthologues, 6 paralogues and is associated with 69 phenotypes. Ubiquitous expression in ovary (RPKM 16.9), placenta (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound Aryl Hydrocarbon Receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

ARNT Products(8)

mRNA	Protein	Name
NM_001197325.2	NP_001184254.1	aryl hydrocarbon receptor nuclear translocator isoform 4
NM_001286035.2	NP_001272964.1	aryl hydrocarbon receptor nuclear translocator isoform 5
NM_001286036.2	NP_001272965.1	aryl hydrocarbon receptor nuclear translocator isoform 6
NM_001350224.2	NP_001337153.1	aryl hydrocarbon receptor nuclear translocator isoform 7
NM_001350225.2	NP_001337154.1	aryl hydrocarbon receptor nuclear translocator isoform 8
NM_001350226.2	NP_001337155.1	aryl hydrocarbon receptor nuclear translocator isoform 9
NM_001668.4	NP_001659.1	aryl hydrocarbon receptor nuclear translocator isoform 1
NM_178427.3	NP_848514.1	aryl hydrocarbon receptor nuclear translocator isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	29454749	GOA
contributes to DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7539918	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	7539918	GOA
enables aryl hydrocarbon receptor binding	IPI IPI: Inferred from physical interaction	9079689	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23275542	GOA
contributes to nuclear receptor activity	IDA IDA: Inferred from direct assay	34521881	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10395741	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	16181639	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	9079689	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16181639	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7539918	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28396409	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	29454749	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7539918	GOA
involved in positive regulation of vascular endothelial growth factor production	IDA IDA: Inferred from direct assay	8756616	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	8756616	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	7539918	GOA
part of nuclear aryl hydrocarbon receptor complex	IDA IDA: Inferred from direct assay	34521881	GOA
located in nucleus	IDA IDA: Inferred from direct assay	34521881	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARNT Protein Structure

HLH

PAS

PAS_11

0
200
400
600
789 a.a.

Protein Preferred Names

Protein Names

aryl hydrocarbon receptor nuclear translocator

class E basic helix-loop-helix protein 2

Related Diseases

Diseases

Alias

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Esophagus Carcinoma In Situ

Carcinoma In Situ Of Esophagus	Carcinoma In Situ Of Oesophagus
Oesophagus Carcinoma In Situ	Severe Esophageal Dysplasia
Stage 0 Carcinoma Of The Esophagus	Stage 0 Carcinoma Of The Oesophagus
Severe Oesophageal Dysplasia

Primary Polycythemia

Familial Erythrocytosis	Familiar Polycythemia
Benign Familial Polycythemia	Congenital Erythrocytosis
Familial Polycythemia	Hereditary Erythrocytosis
Primary Familial Polycythemia	Erythrocytosis, Familial
Polycythemia Vera	Primary Familial Polycythaemia
Primary Inherited Polycythaemia

Erythrocytosis, Familial, 2

Chuvash Polycythemia	ECYT2
Familial Erythrocytosis 2	Autosomal Recessive Benign Erythrocytosis
Polycythemia, Vhl-Dependent	Chuvash Erythromatosis
Chuvash Type Polycythemia	Chuvash Erythrocytosis
Von Hippel-Lindau-Dependent Polycythemia	Polycythemia Chuvash Type
Vhl-Dependent Polycythemia	Erythrocytosis, Familial, Type 2

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity	Retrolental Fibroplasia
EVR1	Criswick-Schepens Syndrome
Rop	Exudative Vitreoretinopathy, Familial, Autosomal Dominant
Fevr, Autosomal Dominant	Premature Retinopathy
Vitreoretinopathy, Exudative 1	Autosomal Dominant Familial Exudative Vitreoretinopathy
Fevr	Vitreoretinopathy, Exudative, Type 1
Retinopathy Of Prematurity Nos	Rlf- [Retrolental Fibroplasia]
Rop - [Retinopathy Of Prematurity]	Terry Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120087	KG-548	Inhibitor	99.92%	Unkown
HY-RS01011	ARNT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W012248	KG-655	Modulator	99.87%	Unkown
HY-112374	NPAS3-IN-1		98.29%	Unkown
HY-P10090	Apoptin-derived peptide		/	Unkown
HY-RS01012	ARNT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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