AHR - aryl hydrocarbon receptor Gene

Homo sapiens

Also known as RP85; bHLHe76

Gene ID: 196 | Gene type: protein coding

About AHR

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:17,298,652-17,346,147 (from NCBI)

This gene has 7 transcripts (splice variants), 151 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in urinary bladder (RPKM 37.2), gall bladder (RPKM 28.4) and 24 other tissues.

Summary

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing Enzymes such as Cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

AHR Products(1)

mRNA	Protein	Name
NM_001621.5	NP_001612.1	aryl hydrocarbon receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15681594	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11782478	GOA
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	9079689	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	9079689	GOA
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	15641800	GOA
enables TFIID-class transcription factor complex binding	IPI IPI: Inferred from physical interaction	15641800	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23275542	GOA
contributes to nuclear receptor activity	IDA IDA: Inferred from direct assay	34521881	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	10395741	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9079689	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	28602820	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28602820	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	15681594	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	15641800	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	17329248	GOA
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	IDA IDA: Inferred from direct assay	17329248	GOA
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	17329248	GOA
involved in cellular response to forskolin	IDA IDA: Inferred from direct assay	17329248	GOA
involved in cellular response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	29454749	GOA
involved in negative regulation of T cell mediated immune response to tumor cell	IDA IDA: Inferred from direct assay	32818467	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	29454749	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	32818467	GOA
involved in regulation of B cell proliferation	IDA IDA: Inferred from direct assay	15681594	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10395741	GOA
involved in regulation of adaptive immune response	IDA IDA: Inferred from direct assay	32818467	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	15681594	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15681594	GOA
involved in response to toxic substance	IDA IDA: Inferred from direct assay	7961644	GOA
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	7961644	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15681594	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17329248	GOA
part of nuclear aryl hydrocarbon receptor complex	IDA IDA: Inferred from direct assay	34521881	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	28602820	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10395741	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15641800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AHR Protein Structure

HLH

PAS

PAS_3

0
200
400
600
800
848 a.a.

Protein Preferred Names

Protein Names

aryl hydrocarbon receptor

AH-receptor

AHR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AHR	P35869	NCOA7	Homo sapiens	Q8NI08	CoIP	10395741
Intra	AHR	P35869	ARNT	Homo sapiens	P27540	Y2H	9704006
Intra	AHR	P35869	ARNT	Homo sapiens	P27540	CoIP	10395741
Intra	AHR	P35869	NCOR2	Homo sapiens	Q9Y618	CoIP	10395741
Cross	AHR	P35869	EBNA3	Epstein-Barr virus	P12977	IF	16257957
Cross	AHR	P35869	EBNA3	Epstein-Barr virus	P12977	Pull Down	16257957
Cross	AHR	P35869	EBNA3	Epstein-Barr virus	P12977	Anti Tag CoIP	16257957

Cross: Cross-species interaction Intra: Intraspecies interaction

AHR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80378	AHR Antibody	WB, ICC/IF	Human
HY-P82417	Aryl Hydrocarbon Receptor Antibody (YA2162)	WB	Human

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 85

RP85	Retinitis Pigmentosa, Type 85

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Aryl Hydrocarbon Hydroxylase Inducibility

Ahh Inducibility

Ahhi

Eosinophilia-Myalgia Syndrome

Eosinophilia Myalgia Syndrome	Ems
L-Tryptophan Induced Ems	Severe Muscle Pain And Abnormally High Eosinophils
Syndrome With Inflammatory And Autoimmune Components That Affect The Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, And Heart

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Penis Agenesis

Micropenis	Agenesis Of The Penis
Penis Agenesia

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109044	Tapinarof	Agonist	99.95%	Unkown
HY-N0178	Diosmin	Agonist	99.51%	Yes
HY-A0083	Methacholine chloride	Agonist	≥98.0%	Yes
HY-B0311	Carbidopa	Modulator	≥98.0%	Yes
HY-B0678	Metaxalone		99.77%	Unkown
HY-17357	Nepafenac	Inhibitor	99.51%	Unkown
HY-W017113	2-Mercaptobenzothiazole	Activator	99.85%	Yes
HY-B0311A	Carbidopa monohydrate	Modulator	≥98.0%	Yes
HY-A0083B	Methacholine bromide	Agonist	/	Unkown
HY-B0678R	Metaxalone (Standard)		/	Unkown
HY-17479	Amfenac		/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0170	Indole-3-carbinol		98.87%	Phase 3
HY-15001	Stemregenin 1	Antagonist	99.95%	Phase 2
HY-16031	AFP464 free base	Inhibitor	/	Phase 2
HY-111449	BAY-218	Antagonist	99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (116)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12028	PD98059		99.96%	Unkown
HY-12684	CH-223191	Antagonist	99.96%	Unkown
HY-15484	Pifithrin-α hydrobromide		98.05%	Unkown
HY-12451	FICZ	Agonist	99.42%	Unkown
HY-W028393	Indole-3-pyruvic acid	Agonist	99.79%	Unkown
HY-135829	BAY 2416964	Antagonist	99.59%	Unkown
HY-19317	ITE	Agonist	99.27%	Unkown
HY-W007355	Skatole		99.97%	Unkown
HY-102023	GNF351	Antagonist	99.90%	Unkown
HY-W015273A	trans-3-Indoleacrylic acid	Inhibitor	99.45%	Unkown
HY-103220	6,2',4'-Trimethoxyflavone	Antagonist	98.09%	Unkown
HY-122208	SGA360	Inhibitor	99.52%	Unkown
HY-135750	VAF347	Agonist	99.90%	Unkown
HY-114740	β-Naphthoflavone		99.95%	Unkown
HY-134217	KYN-101	Inhibitor	98.17%	Unkown
HY-112629	PDM2	Antagonist	98.76%	Unkown
HY-W014502	D-Kynurenine	Agonist	99.67%	Unkown
HY-W011338	Benzyl butyl phthalate	Activator	≥97.0%	Unkown
HY-119019	ASB14780	Inhibitor	99.83%	Unkown
HY-144339	AhR agonist 2		99.53%	Unkown
HY-18619	YL-109	Modulator	99.26%	Unkown
HY-112627	CAY 10465	Agonist	98.30%	Unkown
HY-B0845	Prochloraz		99.77%	Unkown
HY-103221	MeBIO		≥98.0%	Unkown
HY-141609	AHR antagonist 5 free base	Inhibitor	99.56%	Unkown
HY-135831	AHR antagonist 2	Antagonist	99.91%	Unkown
HY-112628	CAY10464	Antagonist	99.77%	Unkown
HY-N4095	Brevifolincarboxylic acid	Inhibitor	99.90%	Unkown
HY-118438	10-Cl-BBQ	Agonist	99.48%	Unkown
HY-136220	AHR antagonist 5	Antagonist	98.05%	Unkown
HY-124421	5F-203	Inducer	99.04%	Unkown
HY-105791	Sulazepam		99.56%	Unkown
HY-117102	ANI-7	Activator	98.13%	Unkown
HY-12545	Brevetoxin-3	Activator	≥95.0%	Unkown
HY-130256	β-NF-JQ1	Inhibitor	99.37%	Unkown
HY-100242	Mivotilate	Activator	99.58%	Unkown
HY-103223	Phortress	Inducer	99.25%	Unkown
HY-111441	1,4-Chrysenequinone	Activator	98.42%	Unkown
HY-17357S	Nepafenac-d5	Inhibitor	98.84%	Unkown
HY-N6264	26-Deoxyactein	Inhibitor	99.76%	Unkown
HY-111450	CB7993113	Antagonist	≥98.0%	Unkown
HY-118474	GW 610	Activator	99.78%	Unkown
HY-118780	CHD-5	Antagonist	≥98.0%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-15001G	Stemregenin 1 (GMP)	Antagonist	/	Unkown
HY-N0586	Norisoboldine	Agonist	/	Unkown
HY-N10123	Indolokine A5	Agonist	≥98.0%	Unkown
HY-RS00483	AHR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W014701	1,4-Dihydroxy-2-naphthoic acid	Activator	99.60%	Unkown
HY-W718300	Indole-3-pyruvic acid-d5		95.00%	Unkown
HY-77278	25-Hydroxytachysterol3	Agonist	98.89%	Unkown
HY-104026CS	L-Kynurenine-13C10 sulfate hemihydrate	Agonist	99.90%	Unkown
HY-117532	PenCB	Inducer	99.94%	Unkown
HY-16031B	AFP464 dihydrochloride	Inhibitor	99.67%	Unkown
HY-N0586A	Norisoboldine hydrochloride	Agonist	99.72%	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-136220A	AHR antagonist 5 hemimaleate	Antagonist	/	Unkown
HY-103222	DiMNF	Modulator	98.01%	Unkown
HY-104026B	L-Kynurenine sulfate	Agonist	/	Unkown
HY-106487	Pridefine		/	Unkown
HY-111157	Dezinamide		/	Unkown
HY-114682	Lenperone	Antagonist	97.26%	Unkown
HY-114682A	Lenperone hydrochloride	Antagonist	/	Unkown
HY-116638	AHR-5333	Inhibitor	/	Unkown
HY-116638A	AHR-5333 (mandelate)	Inhibitor	/	Unkown
HY-117774	AHR-2244 hydrochloride		/	Unkown
HY-118792	AHR activator 1		/	Unkown
HY-119018	AHR-6293	Inhibitor	/	Unkown
HY-119960	AHR-10037	Inhibitor	/	Unkown
HY-120677	AHR-15010	Inhibitor	/	Unkown
HY-123432	AHR-13268D	Inhibitor	/	Unkown
HY-123461	Sul-121 hydrochloride		/	Unkown
HY-125926S	2-Ketodoxapram-d5		/	Unkown
HY-129305	Tampramine fumarate	Inhibitor	/	Unkown
HY-130269	β-Naphthoflavone-CH2-OH		/	Unkown
HY-130270	AhR Ligand-Linker Conjugates 1		/	Unkown
HY-130842	β-Naphthoflavone-CH2-Br		/	Unkown
HY-135671	AhR modulator-1		/	Unkown
HY-135830	AHR antagonist 4	Antagonist	/	Unkown
HY-155505	AHR agonist 4	Agonist	/	Unkown
HY-156908	3-OH-Kynurenamine	Activator	/	Unkown
HY-158167	AhR agonist 5		/	Unkown
HY-158168	AhR agonist 6	Agonist	/	Unkown
HY-158169	AhR agonist 7	Agonist	/	Unkown
HY-161649	hCYP1B1-IN-2	Inhibitor	/	Unkown
HY-168033	AhR agonist 8	Agonist	/	Unkown
HY-19826	Isofistularin-3		/	Unkown
HY-A0083C	Methacholine iodide	Agonist	/	Unkown
HY-B0311AS	Carbidopa-d3 monohydrate	Modulator	≥98.0%	Unkown
HY-B0311D	Carbidopa hydrochloride	Modulator	/	Unkown
HY-B0311S1	Carbidopa-d3-1	Modulator	/	Unkown
HY-B0678S	Metaxalone-d3		≥98.0%	Unkown
HY-B0678S1	Metaxalone-d6		/	Unkown
HY-N12537A	(2R,3S)-PD-1/PD-L1-IN-38		/	Unkown
HY-W011338S	Benzyl butyl phthalate-d4		/	Unkown
HY-W014502R	D-Kynurenine (Standard)	Agonist	/	Unkown
HY-W338764	AHR agonist 3		99.79%	Unkown
HY-W517076	1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin	Agonist	/	Unkown
HY-101745	Rocastine	Antagonist	/	Unkown
HY-101802	Fluzinamide		/	Unkown
HY-104026BS	L-Kynurenine-13C10 sulfate	Agonist	/	Unkown
HY-107063	AHR-1911	Activator	/	Unkown
HY-116148	AHR-11797		/	Unkown
HY-118910	AHR-14310C	Antagonist	/	Unkown
HY-119991	AHR-9294	Inhibitor	/	Unkown
HY-120377	CYP1A1 inhibitor 8a		/	Unkown
HY-124021	Benzyl 2-naphthyl ether		/	Unkown
HY-125926S1	2-Ketodoxapram-d4		/	Unkown
HY-128229	AHR antagonist 6	Antagonist	/	Unkown
HY-130456	AHR 10718		/	Unkown
HY-136891	AHR-16303B		/	Unkown
HY-163665	AHR antagonist 8	Modulator	/	Unkown
HY-170514	1,2,3,7,8,9-Hexachlorodibenzofuran	Ligand	/	Unkown
HY-17479B	Amfenac sodium		/	Unkown
HY-U00010	Dazopride		/	Unkown
HY-W764758	3-OH-Kynurenamine dihydroiodide	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AHR	VGNC	VGNC:54752
Rattus norvegicus	AHR	RGD	RGD:2074
Mus musculus	AHR	MGD	MGI:105043

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