NBR1 - NBR1 autophagy cargo receptor Gene

Homo sapiens

Also known as IAI3B; M17S2; MIG19; 1A1-3B

Gene ID: 4077 | Gene type: protein coding

About NBR1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,170,409-43,211,688 (from NCBI)

This gene has 7 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in testis (RPKM 41.5), thyroid (RPKM 32.2) and 25 other tissues.

Summary

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian Cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific Autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

NBR1 Products(4)

mRNA	Protein	Name
NM_001291571.2	NP_001278500.1	next to BRCA1 gene 1 protein isoform b
NM_001291572.2	NP_001278501.1	next to BRCA1 gene 1 protein isoform c
NM_005899.5	NP_005890.2	next to BRCA1 gene 1 protein isoform a
NM_031862.4	NP_114068.1	next to BRCA1 gene 1 protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19250911	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	19427866	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in macroautophagy	IDA IDA: Inferred from direct assay	19250911	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	19250911	GOA
colocalizes with mitochondrion	IDA IDA: Inferred from direct assay	21296869	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	19250911	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NBR1 Protein Structure

PB1

0
200
400
600
800
966 a.a.

Protein Preferred Names

Protein Names

next to BRCA1 gene 1 protein

B-box protein

NBR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NBR1	Q14596	GSK3A	Homo sapiens	P49840	Pull Down	20368287
Intra	NBR1	Q14596	GSK3A	Homo sapiens	P49840	BioID	34524948
Intra	NBR1	Q14596	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	19250911
Intra	NBR1	Q14596	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Cross	NBR1	Q14596	ATG8	Saccharomyces cerevisiae	P38182	Pull Down	19250911
Cross	NBR1	Q14596	ATG8	Saccharomyces cerevisiae	P38182	Y2H	19250911
Intra	NBR1	Q14596	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	19250911
Intra	NBR1	Q14596	SQSTM1	Homo sapiens	Q13501	Confocal	19250911
Intra	NBR1	Q14596	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	19250911
Intra	NBR1	Q14596	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	NBR1	Q14596	GABARAP	Homo sapiens	O95166	Pull Down	19250911
Intra	NBR1	Q14596	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	NBR1	Q14596	GABARAPL2	Homo sapiens	P60520	Y2H	19250911
Intra	NBR1	Q14596	GABARAPL2	Homo sapiens	P60520	Pull Down	19250911
Intra	NBR1	Q14596	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	NBR1	Q14596	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	NBR1	Q14596	SYT4	Homo sapiens	Q9H2B2	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Myopathy, Myofibrillar, 9, With Early Respiratory Failure

Hereditary Myopathy With Early Respiratory Failure	Hmerf
Myopathy, Proximal, With Early Respiratory Muscle Involvement	Edstrom Myopathy
Mfm-Titinopathy	MFM9
Mprm	Hereditary Inclusion Body Myopathy With Early Respiratory Failure
Hibm-Erf	Myofibrillar Myopathy-Titinopathy
Myofibrillar Myopathy With Early Respiratory Failure	Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant
Myofibrillar Myopathy 9	Myofibrillar Myopathy 9 With Early Respiratory Failure
Autosomal Dominant Distal Myopathy With Early Respiratory Failure	Proximal Myopathy With Early Respiratory Muscle Involvement
Hereditary Proximal Myopathy With Early Respiratory Failure	Admerf
Edström Myopathy	Hmerf-Erf

Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency	VICIS
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum	Dionisi Vici Sabetta Gambarara Syndrome
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum	Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome
Dionisi-Vici-Sabetta-Gambarara Syndrome	Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome	Spiegler-Brooke Syndrome
Familial Cylindromatosis	BRSS
Bss	Sbs
Multiple Familial Trichoepithelioma	Ancell-Spiegler Cylindromas
Familial Multiple Trichoepithelioma	Trichoepithelioma
Fc	Mft
Multiple Familial Trichoepitheliomas	Ccs
Turban Tumor Syndrome	Schilbach-Rott Syndrome
Eccrine Dermal Cylindroma	Familial Multiple Trichoepitheliomata

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Myofibrillar Myopathy

Desmin Related Myopathy	Myotilinopathy
Myopathy, Myofibrillar	Alpha Beta Crystallinopathy
Desmin Storage Myopathy	Desminopathy
Filaminopathy	Protein Surplus Myopathy
Zaspopathy	Myofibrillar Myopathies
Myopathy, Myofibrillar, Desmin-Related	Myopathy, Desmin Storage
Mfm - [Myofibrillar Myopathy]

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146130	ATG7-IN-2	Inhibitor	99.22%	Unkown
HY-146131	ATG7-IN-3	Inhibitor	99.26%	Unkown
HY-RS09061	NBR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NBR1	RGD	RGD:69195
Macaca mulatta	NBR1	VGNC	VGNC:75067
Canis familiaris	NBR1	VGNC	VGNC:43634
Felis catus	NBR1	VGNC	VGNC:68118
Mus musculus	NBR1	MGD	MGI:108498
Bos taurus	NBR1	VGNC	VGNC:31896
Others	NBR1	NCBI

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