MEIS2 - Meis homeobox 2 Gene

Homo sapiens

Also known as MRG1; CPCMR; HsT18361

Gene ID: 4212 | Gene type: protein coding

About MEIS2

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:36,889,204-37,101,311 (from NCBI)

This gene has 38 transcripts (splice variants), 289 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in endometrium (RPKM 12.8), prostate (RPKM 12.0) and 24 other tissues.

Summary

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

MEIS2 Products(8)

mRNA	Protein	Name
NM_001220482.2	NP_001207411.1	homeobox protein Meis2 isoform d
NM_002399.4	NP_002390.1	homeobox protein Meis2 isoform f
NM_170674.5	NP_733774.1	homeobox protein Meis2 isoform b
NM_170675.5	NP_733775.1	homeobox protein Meis2 isoform c
NM_170676.5	NP_733776.1	homeobox protein Meis2 isoform d
NM_170677.5	NP_733777.1	homeobox protein Meis2 isoform a
NM_172315.3	NP_758526.1	homeobox protein Meis2 isoform g
NM_172316.3	NP_758527.1	homeobox protein Meis2 isoform h

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	26550823	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10764806	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10764806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19559479	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17178831	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cardiac muscle myoblast proliferation	IDA IDA: Inferred from direct assay	26512644	GOA
involved in positive regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	26512644	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10764806	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEIS2 Protein Structure

Homeobox_KN

0
100
200
300
400
477 a.a.

Protein Preferred Names

Protein Names

homeobox protein Meis2

Meis homolog 2

MEIS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MEIS2	O14770	CCDC196	Homo sapiens	A0A1B0GWI1	Validated Y2H	25416956
Intra	MEIS2	O14770	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Array	25416956
Intra	MEIS2	O14770	ANXA1	Homo sapiens	Q5TZZ9	Validated Y2H	25416956
Intra	MEIS2	O14770	ANXA1	Homo sapiens	Q5TZZ9	Y2H Array	25416956
Intra	MEIS2	O14770	PBX1	Homo sapiens	P40424	Y2H Array	20211142
Intra	MEIS2	O14770	PBX1	Homo sapiens	P40424	Anti Tag CoIP	33961781
Intra	MEIS2	O14770	OSGIN1	Homo sapiens	Q9UJX0	Y2H Array	25416956
Intra	MEIS2	O14770	OSGIN1	Homo sapiens	Q9UJX0	Y2H Array	31515488
Intra	MEIS2	O14770	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	25416956
Intra	MEIS2	O14770	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Cross	MEIS2	O14770	gag-pro-pol	Human T-cell leukemia virus	P03363	Y2H Array	22458338
Cross	MEIS2	O14770	gag-pro-pol	Human T-cell leukemia virus	P03363	MAPPIT	22458338
Cross	MEIS2	O14770	gag-pro-pol	Human T-cell leukemia virus	P03363	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

MEIS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82033	MEIS2 Antibody (YA1778)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Cleft Palate, Cardiac Defects, And Mental Retardation

Cardiac Malformation, Cleft Lip/Palate, Microcephaly, And Digital Anomalies	CPCMR
Cleft Palate, Cardiac Defects, And Intellectual Disabillity	Cleft Palate, Cardiac Defects, And Intellectual Disability
Cardiac Malformation, Cleft Lip-Palate, Microcephaly And Digital Anomalies

Chromosome 15q14 Deletion Syndrome

15q14 Microdeletion Syndrome	Del(15)(Q14)
Monosomy 15q14

Cleft Palate, Cardiac Defects, And Intellectual Disability

Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay

CAKUTHED	Doid:0112359
Anomalies, Congenital, Kidney And Urinary Tract Syndrome With/Without Hearing Loss, Abnormal Ears, Or Developmental Delay

Epilepsy, Familial Temporal Lobe, 4

ETL4	Epilepsy, Occipitotemporal Lobe, And Migraine With Aura
Epolm	Familial Temporal Lobe Epilepsy 4
Occipitotemporal Lobe Epilepsy And Migraine With Aura

Anemia, Congenital Dyserythropoietic, Type Ib

CDAN1B	Congenital Dyserythropoietic Anemia Type Ib
Cda, Type Ib	Congenital Dyserythropoietic Anemia Type Type 1b
Dyserythropoietic Anemia, Congenital, Type Ib	Anemia, Congenital Dyserythropoietic, 1b
Cda Ib	Anemia, Dyserythropoietic, Congenital
Anemia, Dyserythropoietic, Congenital, Type Ib

Breast Lipoma

Lipoma Of Breast

Peters-Plus Syndrome

Krause-Kivlin Syndrome	Peters Plus Syndrome
Peters Anomaly	Irido-Corneo-Trabecular Dysgenesis
PTRPLS	Peters Anomaly With Short-Limb Dwarfism
Peters Anomaly-Short Limb Dwarfism Syndrome	Peters Anomaly With Short Limb Dwarfism
Peters Congenital Glaucoma	Krause-Van Schooneveld-Kivlin Syndrome
Peters' Plus Syndrome	Peters'-Plus Syndrome
Anomaly Peters

Axenfeld-Rieger Syndrome

Axenfeld Syndrome	Rieger Syndrome
Rieger Anomaly	Axenfeld Anomaly
Anomaly, Rieger'S	Hagedoom Syndrome
Rgs - Rieger Syndrome	Rieger'S Anomaly
Goniodysgenesis Hypodontia	Iridogoniodysgenesis With Somatic Anomalies
Ars	Axenfeld And Rieger Anomaly
Axra	Axrs
Rieger Eye Malformation Sequence

Aniridia 1

Aniridia	Congenital Aniridia
AN1	An
Cataract With Late-Onset Corneal Dystrophy	Aplasia Of Iris
Absent Iris	Irideremia
Aniridia Ii, Formerly	An2, Formerly
An2	Aniridia Type Ii
Aniridia, Type 1	An-1
Absence Of Iris	Agenesis Of Iris
Congenital Absence Of Iris	Hereditary Aniridia
Sporadic Aniridia

Orofacial Cleft

Cleft, Orofacial

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08326	MEIS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MEIS2	RGD	RGD:1305198
Mus musculus	MEIS2	MGD	MGI:108564
Macaca mulatta	MEIS2	VGNC	VGNC:74702
Bos taurus	MEIS2	VGNC	VGNC:31382
Felis catus	MEIS2	VGNC	VGNC:80914
Canis familiaris	MEIS2	VGNC	VGNC:43154

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