MAP3K11 - mitogen-activated protein kinase kinase kinase 11 Gene

Homo sapiens

Also known as MLK3; PTK1; SPRK; MLK-3; MEKK11

Gene ID: 4296 | Gene type: protein coding

About MAP3K11

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,597,757-65,614,221 (from NCBI)

This gene has 13 transcripts (splice variants), 184 orthologues and 23 paralogues. Ubiquitous expression in spleen (RPKM 25.3), fat (RPKM 22.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

MAP3K11 Products(1)

mRNA	Protein	Name
NM_002419.4	NP_002410.1	mitogen-activated protein kinase kinase kinase 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables JUN kinase kinase kinase activity	IMP IMP: Inferred from mutant phenotype	15258589	GOA
enables MAP kinase kinase kinase activity	IMP IMP: Inferred from mutant phenotype	15258589	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9829970	GOA
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	17584736	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9003777	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	9829970	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8195146	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	15258589	GOA
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	15258589	GOA
involved in cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	15258589	GOA
involved in microtubule-based process	IMP IMP: Inferred from mutant phenotype	12529434	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	17584736	GOA
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	17584736	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	8195146	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11053428	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	12529434	GOA
located in microtubule	IDA IDA: Inferred from direct assay	12529434	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K11 Protein Structure

SH3_9

Pkinase_Tyr

0
200
400
600
800
847 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 11

SH3 domain-containing proline-rich kinase

MAP3K11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP3K11	Q16584	NF2	Homo sapiens	P35240	Pull Down	20890305
Intra	MAP3K11	Q16584	NF2	Homo sapiens	P35240	Anti Bait CoIP	20890305
Intra	MAP3K11	Q16584	NF2	Homo sapiens	P35240	Protein Kinase Assay	20890305
Cross	MAP3K11	Q16584	Map4k1	Mus musculus	P70218	Anti Tag CoIP	9003777
Intra	MAP3K11	Q16584	CDC42	Homo sapiens	P60953	Anti Tag CoIP	20890305
Intra	MAP3K11	Q16584	CDC42	Homo sapiens	P60953	PLA	25241761
Cross	MAP3K11	Q16584	Q99IB8-PRO_0000045602	Hepatitis C virus	Q99IB8-PRO_0000045602	Anti Bait CoIP	23857585
Cross	MAP3K11	Q16584	Q99IB8-PRO_0000045602	Hepatitis C virus	Q99IB8-PRO_0000045602	Anti Tag CoIP	23857585
Cross	MAP3K11	Q16584	Q99IB8-PRO_0000045602	Hepatitis C virus	Q99IB8-PRO_0000045602	Confocal	23857585

Cross: Cross-species interaction Intra: Intraspecies interaction

MAP3K11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83492	MLK3 Antibody (YA3237)	WB, ICC/IF	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08048	MAP3K11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAP3K11	RGD	RGD:1359261
Bos taurus	MAP3K11	VGNC	VGNC:31189
Felis catus	MAP3K11	VGNC	VGNC:68156
Mus musculus	MAP3K11	MGD	MGI:1346880
Canis familiaris	MAP3K11	VGNC	VGNC:42967
Others	MAP3K11	NCBI

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