2. Gene
  3. MLLT3 - MLLT3 super elongation complex subunit Gene

MLLT3 - MLLT3 super elongation complex subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AF9; YEATS3

Gene ID: 4300 | Gene type: protein coding

About MLLT3

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:20,341,669-20,622,499 (from NCBI)

This gene has 9 transcripts (splice variants), 259 orthologues, 2 paralogues and is associated with 85 phenotypes. Ubiquitous expression in thyroid (RPKM 6.2), colon (RPKM 4.6) and 23 other tissues.

Summary

Enables chromatin binding activity and lysine-acetylated histone binding activity. Involved in several processes, including hematopoietic stem cell differentiation; positive regulation of transcription, DNA-templated; and regulation of stem cell division. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in cytosol and nucleoplasm. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

MLLT3 Products(2)

mRNA Protein Name
NM_001286691.2 NP_001273620.1 protein AF-9 isoform b
NM_004529.4 NP_004520.2 protein AF-9 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
25417107 GOA
enables histone binding IDA
IDA: Inferred from direct assay
27105114 GOA
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
25417107 GOA
enables modification-dependent protein binding IDA
IDA: Inferred from direct assay
27105114 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
23260655 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in hematopoietic stem cell differentiation IDA
IDA: Inferred from direct assay
31776511 GOA
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19591803 GOA
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19591803 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
25417107 GOA
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
19591803 GOA
involved in regulation of chromatin organization IMP
IMP: Inferred from mutant phenotype
31776511 GOA
involved in regulation of stem cell division IDA
IDA: Inferred from direct assay
31776511 GOA
Cellular Component GO Annotation Evidence Reference Source
part of transcription elongation factor complex IDA
IDA: Inferred from direct assay
22195968 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLLT3 Protein Structure

YEATS

YEATS: YEATS family (29 - 111)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 568 a.a.
Protein Preferred Names Protein Names

protein AF-9

ALL1-fused gene from chromosome 9 protein

MLLT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MLLT3 P42568 ZNF572 Homo sapiens Q7Z3I7
Validated Y2H
32296183
Intra MLLT3 P42568 ZNF572 Homo sapiens Q7Z3I7
Y2H Array
32296183
Intra MLLT3 P42568 ZNF572 Homo sapiens Q7Z3I7
Y2H Prey Pooling
32296183
Intra MLLT3 P42568 VAX1 Homo sapiens Q5SQQ9-2
Y2H Array
32296183
Intra MLLT3 P42568 VAX1 Homo sapiens Q5SQQ9-2
Y2H Prey Pooling
32296183
Intra MLLT3 P42568 VAX1 Homo sapiens Q5SQQ9-2
Validated Y2H
32296183
Intra MLLT3 P42568 BCOR Homo sapiens Q6W2J9-1
NMR
23260655
Intra MLLT3 P42568 BCOR Homo sapiens Q6W2J9-1
Pull Down
23260655
Intra MLLT3 P42568 AFF1 Homo sapiens P51825
GMS
23260655
Intra MLLT3 P42568 AFF1 Homo sapiens P51825
CD
23260655
Intra MLLT3 P42568 AFF1 Homo sapiens P51825
Anti Tag CoIP
21729782
Intra MLLT3 P42568 AFF1 Homo sapiens P51825
NMR
23260655
Intra MLLT3 P42568 AFF1 Homo sapiens P51825
Pull Down
23260655
Intra MLLT3 P42568 DOT1L Homo sapiens Q8TEK3
Pull Down
23260655
Intra MLLT3 P42568 DOT1L Homo sapiens Q8TEK3
Anti Tag CoIP
20203130
Intra MLLT3 P42568 DOT1L Homo sapiens Q8TEK3
NMR
23260655
Intra MLLT3 P42568 DOT1L Homo sapiens Q8TEK3
Anti Tag CoIP
20153263
Intra MLLT3 P42568 MIIP Homo sapiens Q5JXC2
Validated Y2H
32296183
Intra MLLT3 P42568 MIIP Homo sapiens Q5JXC2
Y2H Prey Pooling
32296183
Intra MLLT3 P42568 MIIP Homo sapiens Q5JXC2
Y2H Array
32296183
Intra MLLT3 P42568 AFF4 Homo sapiens Q9UHB7
Anti Tag CoIP
21729782
Intra MLLT3 P42568 CBX8 Homo sapiens Q9HC52
Pull Down
23260655
Intra MLLT3 P42568 CBX8 Homo sapiens Q9HC52
NMR
23260655
Intra MLLT3 P42568 APPBP2 Homo sapiens Q92624
Y2H Pooling
16189514
Intra MLLT3 P42568 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra MLLT3 P42568 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Intra MLLT3 P42568 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra MLLT3 P42568 FAM9A Homo sapiens Q8IZU1
Validated Y2H
32296183
Intra MLLT3 P42568 FAM9A Homo sapiens Q8IZU1
Y2H Prey Pooling
32296183
Intra MLLT3 P42568 FAM9A Homo sapiens Q8IZU1
Y2H Array
32296183
Intra MLLT3 P42568 ALKBH4 Homo sapiens Q9NXW9
Validated Y2H
32296183
Intra MLLT3 P42568 ALKBH4 Homo sapiens Q9NXW9
Y2H
23145062
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Myeloid Leukemia With T(9;11)(P22;Q23)

Aml With T(9

11)(P22

Q23)
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Acute Leukemia

Stem Cell Leukaemia

Stem Cell Leukemia

Acute Leukemias

Acute Undifferentiated Leukemia

Undifferentiated Leukemia

Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

Blast Cell Leukaemia

Blast Leukaemia

Blastic Leukaemia

Undifferentiated Leukaemia
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Childhood Leukemia
Neonatal Leukemia
Childhood Acute Myeloid Leukemia

Childhood Acute Myeloid Leukaemia

Paediatric Acute Myeloid Leukaemia

Pediatric Acute Myeloid Leukemia
Microphthalmia, Syndromic 2

Oculofaciocardiodental Syndrome

Ofcd Syndrome

MCOPS2

Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects

Syndromic Microphthalmia 2

Anop2

Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome

Maa2

Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects

Syndromic Microphthalmia Type 2

Oculo-Facio-Cardio-Dental Syndrome

Anop2, Formerly

Maa2, Formerly

Microphthalmia Syndromic 2

Oculo Facio Cardio Dental Syndrome

Microphthalmia, Syndromic, 2

Marashi-Gorlin Syndrome

Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects

Microphthalmia, Syndromic, Type 2
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia

Acute Leukemia Of Ambiguous Lineage

Acute Undifferentiated Leukemia

Acute Leukemia Of Indeterminate Lineage

Hybrid Acute Leukemia

Mixed Lineage Acute Leukemia

All With Myeloid Markers

Aml With Lymphoid Markers

Acute Leukemia Of Undetermined Lineage

Bal

Biphenotypic Acute Leukemia

Undifferentiated Acute Leukemia

Mpal

Acute Myeloid Leukemia, Minimal Differentiation, Fab M0

Leukemia, Biphenotypic, Acute
Leukemia, Acute Monocytic

Acute Monocytic Leukemia

Acute Monoblastic Leukemia And Acute Monocytic Leukemia

Acute Monocytic Leukaemia

Acute Monocytic Leukaemia Without Mention Of Remission

Acute Monocytic Leukemia Without Mention Of Remission

Acute Monocytic Leukemia, Fab M5

Acute Monocytic Leukemia, Morphology

Leukemia, Monocytic, Acute

M5b Acute Differentiated Monocytic Leukemia
Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy

Patterned Macular Dystrophy 3

MDPT3

Mcrpe
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112804 SGC-iMLLT Inhibitor 98.96% Unkown
HY-155412 PFI-6 ≥99.0% Unkown
HY-RS08496 MLLT3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MLLT3 VGNC VGNC:97510
Bos taurus MLLT3 VGNC VGNC:31503
Rattus norvegicus MLLT3 RGD RGD:620940
Mus musculus MLLT3 MGD MGI:1917372
Canis familiaris MLLT3 VGNC VGNC:43262
Macaca mulatta MLLT3 VGNC VGNC:74882