FOXO4 - forkhead box O4 Gene

Homo sapiens

Also known as AFX; AFX1; MLLT7

Gene ID: 4303 | Gene type: protein coding

About FOXO4

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,095,851-71,103,532 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues, 42 paralogues and is associated with 52 phenotypes. Broad expression in placenta (RPKM 74.9), testis (RPKM 15.0) and 21 other tissues.

Summary

This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

FOXO4 Products(2)

mRNA	Protein	Name
NM_001170931.2	NP_001164402.1	forkhead box protein O4 isoform 2
NM_005938.4	NP_005929.2	forkhead box protein O4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10783894	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11689711	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10783894	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16054032	GOA
enables beta-catenin binding	IDA IDA: Inferred from direct assay	15905404	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15126506	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25609649	GOA
enables nucleic acid binding	EXP EXP: Inferred from Experiment	11352721	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15084259	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	22972301	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	10217147	GOA
involved in negative regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	10783894	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	12761217	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10783894	GOA
involved in negative regulation of smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	16054032	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11689711	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15126506	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	36075446	GOA
involved in stem cell differentiation	IMP IMP: Inferred from mutant phenotype	22972301	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16964248	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16272144	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16272144	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXO4 Protein Structure

Forkhead

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

forkhead box protein O4

fork head domain transcription factor AFX1

FOXO4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXO4	P98177	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	15126506
Intra	FOXO4	P98177	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	FOXO4	P98177	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	FOXO4	P98177	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	15084259
Intra	FOXO4	P98177	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	FOXO4	P98177	Foxg1	Mus musculus	Q60987	Anti Tag CoIP	15084259
Intra	FOXO4	P98177	SMAD3	Homo sapiens	P84022	Anti Tag CoIP	15084259
Intra	FOXO4	P98177	FOXO4	Homo sapiens	P98177	TAP	25609649
Intra	FOXO4	P98177	H1-2	Homo sapiens	P16403	Crosslink	30021884
Intra	FOXO4	P98177	SFN	Homo sapiens	P31947	Validated Y2H	25416956
Intra	FOXO4	P98177	Crebbp	Mus musculus	P45481	Anti Tag CoIP	15126506

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153347	JY-2		99.75%	Unkown
HY-P4157	FOXO4-DRI		99.93%	Unkown
HY-P4157A	FOXO4-DRI acetate		/	Unkown
HY-RS05071	FOXO4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXO4	VGNC	VGNC:40964
Macaca mulatta	FOXO4	VGNC	VGNC:72712
Rattus norvegicus	FOXO4	RGD	RGD:1561201
Bos taurus	FOXO4	VGNC	VGNC:29100
Mus musculus	FOXO4	MGD	MGI:1891915
Felis catus	FOXO4	VGNC	VGNC:68274

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