2. Gene
  3. RNASEK - ribonuclease K Gene

RNASEK - ribonuclease K Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 440400 | Gene type: protein coding

About RNASEK

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,012,624-7,014,532 (from NCBI)

This gene has 10 transcripts (splice variants) and 229 orthologues. Ubiquitous expression in adrenal (RPKM 84.0), kidney (RPKM 67.2) and 25 other tissues.

Summary

Enables endoribonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNASEK Products(1)

mRNA Protein Name
NM_001004333.5 NP_001004333.3 ribonuclease kappa
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA endonuclease activity IDA
IDA: Inferred from direct assay
17881363 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endosomal lumen acidification IPI
IPI: Inferred from physical interaction
26212330 GOA
involved in proton transmembrane transport IPI
IPI: Inferred from physical interaction
26212330 GOA
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
26212330 GOA
involved in receptor-mediated endocytosis of virus by host cell IMP
IMP: Inferred from mutant phenotype
26212330 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
33065002 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribonuclease kappa

RNase kappa

RNASEK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RNASEK Q6P5S7 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra RNASEK Q6P5S7 ARV1 Homo sapiens Q9H2C2
Validated Y2H
32296183
Intra RNASEK Q6P5S7 ATP13A1 Homo sapiens Q9HD20-3
Validated Y2H
32296183
Intra RNASEK Q6P5S7 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra RNASEK Q6P5S7 TREX1 Homo sapiens Q9NSU2-1
Validated Y2H
32296183
Intra RNASEK Q6P5S7 ZDHHC21 Homo sapiens Q8IVQ6
Validated Y2H
32296183
Intra RNASEK Q6P5S7 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra RNASEK Q6P5S7 FIS1 Homo sapiens Q9Y3D6
Validated Y2H
32296183
Intra RNASEK Q6P5S7 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra RNASEK Q6P5S7 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra RNASEK Q6P5S7 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra RNASEK Q6P5S7 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra RNASEK Q6P5S7 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra RNASEK Q6P5S7 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
Intra RNASEK Q6P5S7 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rift Valley Fever

Rfv - [Rift Valley Fever]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12028 RNASEK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RNASEK MGD MGI:106369
Felis catus RNASEK VGNC VGNC:64659
Bos taurus RNASEK VGNC VGNC:34002
Rattus norvegicus RNASEK RGD RGD:1305687
Canis familiaris RNASEK VGNC VGNC:54351