MSH4 - mutS homolog 4 Gene

Homo sapiens

Also known as POF20; SPGF2

Gene ID: 4438 | Gene type: protein coding

About MSH4

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:75,796,882-75,913,242 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Biased expression in testis (RPKM 2.6) and small intestine (RPKM 0.1).

Summary

This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]

MSH4 Products(1)

mRNA	Protein	Name
NM_002440.4	NP_002431.2	mutS protein homolog 4

MSH4 Protein Structure

MutS_II

MutS_III

MutS_IV

MutS_V

0
200
400
600
800
936 a.a.

Protein Preferred Names

Protein Names

mutS protein homolog 4

hMSH4

MSH4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MSH4	O15457	MSH5	Homo sapiens	O43196	Protein 3 Hybrid	16397227
Intra	MSH4	O15457	MSH5	Homo sapiens	O43196	Y2H	16397227
Intra	MSH4	O15457	EIF3F	Homo sapiens	O00303	Pull Down	23725059
Intra	MSH4	O15457	EIF3F	Homo sapiens	O00303	Y2H	23725059
Intra	MSH4	O15457	EIF3F	Homo sapiens	O00303	Anti Tag CoIP	23725059

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 2

SPGF2	Aspermiogenesis Factor
Asg

Premature Ovarian Failure 20

POF20

Oligospermia

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Genetic Non-Acquired Premature Ovarian Failure

Immunodeficiency 25

Immunodeficiency Due To Defect In Cd3-Zeta	IMD25
Immunodeficiency, Type 25

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3662	Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Activator	99.95%	Unkown
HY-RS08711	MSH4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MSH4	VGNC	VGNC:74933
Canis familiaris	MSH4	VGNC	VGNC:43440
Mus musculus	MSH4	MGD	MGI:1860077
Felis catus	MSH4	VGNC	VGNC:107586
Rattus norvegicus	MSH4	RGD	RGD:1309190
Bos taurus	MSH4	VGNC	VGNC:31695

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