EIF3F - eukaryotic translation initiation factor 3 subunit F Gene

Homo sapiens

Also known as MRT67; EIF3S5; eIF3-p47

Gene ID: 8665 | Gene type: protein coding

About EIF3F

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,987,337-8,001,852 (from NCBI)

This gene has 15 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 140.6), lymph node (RPKM 83.6) and 25 other tissues.

Summary

Enables Deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]

EIF3F Products(1)

mRNA	Protein	Name
NM_003754.3	NP_003745.1	eukaryotic translation initiation factor 3 subunit F

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables metal-dependent deubiquitinase activity	IDA IDA: Inferred from direct assay	21124883	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	9573242	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3F Protein Structure

JAB

MitMem_reg

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit F

deubiquitinating enzyme eIF3f

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 67

MRT67	Mental Retardation, Autosomal Recessive 67
Autosomal Recessive Intellectual Developmental Disorder 67

Syndromic Intellectual Disability

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04262	EIF3F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EIF3F	VGNC	VGNC:82013
Mus musculus	EIF3F	MGD	MGI:1913335
Macaca mulatta	EIF3F	VGNC	VGNC:72191
Rattus norvegicus	EIF3F	RGD	RGD:1306112
Bos taurus	EIF3F	VGNC	VGNC:28396
Canis familiaris	EIF3F	VGNC	VGNC:40272
Others	EIF3F	NCBI

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