EIF3F - eukaryotic translation initiation factor 3 subunit F Gene

Homo sapiens

Also known as MRT67; EIF3S5; eIF3-p47

Gene ID: 8665 | Gene type: protein coding

About EIF3F

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,987,337-8,001,852 (from NCBI)

This gene has 15 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 140.6), lymph node (RPKM 83.6) and 25 other tissues.

Summary

Enables Deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]

EIF3F Products(1)

mRNA	Protein	Name
NM_003754.3	NP_003745.1	eukaryotic translation initiation factor 3 subunit F

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables metal-dependent deubiquitinase activity	IDA IDA: Inferred from direct assay	21124883	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	9573242	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3F Protein Structure

JAB

MitMem_reg

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit F

deubiquitinating enzyme eIF3f

EIF3F Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3F	O00303	NF2	Homo sapiens	P35240-4	Validated Y2H	32814053
Intra	EIF3F	O00303	NF2	Homo sapiens	P35240-4	Y2H Array	32814053
Intra	EIF3F	O00303	NF2	Homo sapiens	P35240-4	Y2H Pooling	32814053
Intra	EIF3F	O00303	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Array	32296183
Intra	EIF3F	O00303	RTP5	Homo sapiens	Q14D33	Validated Y2H	32296183
Intra	EIF3F	O00303	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	EIF3F	O00303	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	EIF3F	O00303	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	EIF3F	O00303	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	EIF3F	O00303	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	EIF3F	O00303	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	EIF3F	O00303	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	EIF3F	O00303	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	EIF3F	O00303	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	EIF3F	O00303	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	EIF3F	O00303	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	EIF3F	O00303	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	EIF3F	O00303	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	EIF3F	O00303	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	EIF3F	O00303	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	EIF3F	O00303	TIMM10B	Homo sapiens	Q9Y5J6	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	TIMM10B	Homo sapiens	Q9Y5J6	Y2H Array	32296183
Intra	EIF3F	O00303	TIMM10B	Homo sapiens	Q9Y5J6	Validated Y2H	32296183
Intra	EIF3F	O00303	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	EIF3F	O00303	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	EIF3F	O00303	CDK11B	Homo sapiens	P21127	Protein Kinase Assay	19245811
Intra	EIF3F	O00303	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Array	32296183
Intra	EIF3F	O00303	GLE1	Homo sapiens	Q53GS7	Anti Tag CoIP	18724935
Intra	EIF3F	O00303	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	EIF3F	O00303	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	EIF3F	O00303	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	EIF3F	O00303	MKRN2	Homo sapiens	Q9H000	Validated Y2H	32296183
Intra	EIF3F	O00303	MKRN2	Homo sapiens	Q9H000	Y2H Array	32296183
Intra	EIF3F	O00303	MKRN2	Homo sapiens	Q9H000	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	EIF3F	O00303	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	EIF3F	O00303	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	EIF3F	O00303	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	EIF3F	O00303	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	EIF3F	O00303	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	EIF3F	O00303	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	EIF3F	O00303	FBXO32	Homo sapiens	Q969P5	Pull Down	18354498
Intra	EIF3F	O00303	FBXO32	Homo sapiens	Q969P5	Y2H	18354498
Intra	EIF3F	O00303	FBXO32	Homo sapiens	Q969P5	Anti Tag CoIP	18354498
Intra	EIF3F	O00303	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	EIF3F	O00303	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	EIF3F	O00303	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	Pull Down	23623729
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	33961781
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	28514442
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	MAPPIT	25416956
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	18599441
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	SLCA	19748344
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	Y2H Array	32296183
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	SLCA	18599441
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	Y2H Pooling	16169070
Intra	EIF3F	O00303	EIF3M	Homo sapiens	Q7L2H7	Validated Y2H	32296183
Intra	EIF3F	O00303	RIN1	Homo sapiens	Q13671	Validated Y2H	32296183
Intra	EIF3F	O00303	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
Intra	EIF3F	O00303	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	24396066
Intra	EIF3F	O00303	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	EIF3F	O00303	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	EIF3F	O00303	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	EIF3F	O00303	SUOX	Homo sapiens	P51687	Validated Y2H	32296183
Intra	EIF3F	O00303	CYCS	Homo sapiens	P99999	Y2H Pooling	32814053
Intra	EIF3F	O00303	CYCS	Homo sapiens	P99999	Validated Y2H	32814053
Intra	EIF3F	O00303	CYCS	Homo sapiens	P99999	Y2H Array	32814053
Intra	EIF3F	O00303	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	EIF3F	O00303	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	EIF3F	O00303	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	EIF3F	O00303	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	EIF3F	O00303	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	EIF3F	O00303	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	EIF3F	O00303	PKN1	Homo sapiens	Q16512	Validated Y2H	32296183
Intra	EIF3F	O00303	MSH4	Homo sapiens	O15457	Anti Tag CoIP	23725059
Cross	EIF3F	O00303	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034
Intra	EIF3F	O00303	EIF3H	Homo sapiens	O15372	SLCA	19748344
Intra	EIF3F	O00303	EIF3H	Homo sapiens	O15372	SLCA	18599441
Intra	EIF3F	O00303	EIF3H	Homo sapiens	O15372	Anti Tag CoIP	33961781
Intra	EIF3F	O00303	EIF3H	Homo sapiens	O15372	Anti Tag CoIP	28514442
Intra	EIF3F	O00303	EIF3H	Homo sapiens	O15372	Pull Down	23623729
Intra	EIF3F	O00303	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	EIF3F	O00303	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	EIF3F	O00303	RABIF	Homo sapiens	P47224	Validated Y2H	32296183
Intra	EIF3F	O00303	MYDGF	Homo sapiens	Q969H8	Validated Y2H	32296183
Intra	EIF3F	O00303	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	EIF3F	O00303	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	EIF3F	O00303	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	EIF3F	O00303	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	EIF3F	O00303	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	EIF3F	O00303	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	EIF3F	O00303	HGS	Homo sapiens	O14964	Validated Y2H	32296183
Intra	EIF3F	O00303	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32296183
Intra	EIF3F	O00303	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32296183
Intra	EIF3F	O00303	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	EIF3F	O00303	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	EIF3F	O00303	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	EIF3F	O00303	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	EIF3F	O00303	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	EIF3F	O00303	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	EIF3F	O00303	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	EIF3F	O00303	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	EIF3F	O00303	COL1A2	Homo sapiens	P08123	Y2H Prey Pooling	32296183
Intra	EIF3F	O00303	COL1A2	Homo sapiens	P08123	Validated Y2H	32296183
Intra	EIF3F	O00303	COL1A2	Homo sapiens	P08123	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 67

MRT67	Mental Retardation, Autosomal Recessive 67
Autosomal Recessive Intellectual Developmental Disorder 67

Syndromic Intellectual Disability

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04262	EIF3F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EIF3F	VGNC	VGNC:82013
Mus musculus	EIF3F	MGD	MGI:1913335
Macaca mulatta	EIF3F	VGNC	VGNC:72191
Rattus norvegicus	EIF3F	RGD	RGD:1306112
Bos taurus	EIF3F	VGNC	VGNC:28396
Canis familiaris	EIF3F	VGNC	VGNC:40272
Others	EIF3F	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.