2. Gene
  3. EIF3F - eukaryotic translation initiation factor 3 subunit F Gene

EIF3F - eukaryotic translation initiation factor 3 subunit F Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRT67; EIF3S5; eIF3-p47

Gene ID: 8665 | Gene type: protein coding

About EIF3F

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,987,337-8,001,852 (from NCBI)

This gene has 15 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 140.6), lymph node (RPKM 83.6) and 25 other tissues.

Summary

Enables Deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]

EIF3F Products(1)

mRNA Protein Name
NM_003754.3 NP_003745.1 eukaryotic translation initiation factor 3 subunit F
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables metal-dependent deubiquitinase activity IDA
IDA: Inferred from direct assay
21124883 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
contributes to translation initiation factor activity IDA
IDA: Inferred from direct assay
17581632 GOA
Biological Process GO Annotation Evidence Reference Source
involved in IRES-dependent viral translational initiation IDA
IDA: Inferred from direct assay
9573242 GOA
involved in translational initiation IDA
IDA: Inferred from direct assay
17581632 GOA
Cellular Component GO Annotation Evidence Reference Source
part of eukaryotic translation initiation factor 3 complex IDA
IDA: Inferred from direct assay
17322308 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: Inferred from physical interaction
17322308 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3F Protein Structure

JAB

JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease (89 - 195)

MitMem_reg

MitMem_reg: Maintenance of mitochondrial structure and function (243 - 356)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 3 subunit F

deubiquitinating enzyme eIF3f

EIF3F Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
EIF3F O00303 NF2 Homo sapiens P35240-4
Validated Y2H
32814053
Intra
EIF3F O00303 NF2 Homo sapiens P35240-4
Y2H Array
32814053
Intra
EIF3F O00303 NF2 Homo sapiens P35240-4
Y2H Pooling
32814053
Intra
EIF3F O00303 CCDC196 Homo sapiens A0A1B0GWI1
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 CCDC196 Homo sapiens A0A1B0GWI1
Y2H Array
32296183
Intra
EIF3F O00303 RTP5 Homo sapiens Q14D33
Validated Y2H
32296183
Intra
EIF3F O00303 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra
EIF3F O00303 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra
EIF3F O00303 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
EIF3F O00303 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
EIF3F O00303 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
EIF3F O00303 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
EIF3F O00303 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
EIF3F O00303 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
EIF3F O00303 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
EIF3F O00303 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
EIF3F O00303 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
EIF3F O00303 BAG6 Homo sapiens P46379-2
Validated Y2H
32814053
Intra
EIF3F O00303 BAG6 Homo sapiens P46379-2
Y2H Array
32814053
Intra
EIF3F O00303 BAG6 Homo sapiens P46379-2
Y2H Pooling
32814053
Intra
EIF3F O00303 VEZF1 Homo sapiens Q14119
Validated Y2H
32296183
Intra
EIF3F O00303 TIMM10B Homo sapiens Q9Y5J6
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 TIMM10B Homo sapiens Q9Y5J6
Y2H Array
32296183
Intra
EIF3F O00303 TIMM10B Homo sapiens Q9Y5J6
Validated Y2H
32296183
Intra
EIF3F O00303 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 POU6F2 Homo sapiens P78424
Validated Y2H
32296183
Intra
EIF3F O00303 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
EIF3F O00303 CDK11B Homo sapiens P21127
Protein Kinase Assay
19245811
Intra
EIF3F O00303 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
EIF3F O00303 GLE1 Homo sapiens Q53GS7
Anti Tag CoIP
18724935
Intra
EIF3F O00303 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
EIF3F O00303 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
EIF3F O00303 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
EIF3F O00303 MKRN2 Homo sapiens Q9H000
Validated Y2H
32296183
Intra
EIF3F O00303 MKRN2 Homo sapiens Q9H000
Y2H Array
32296183
Intra
EIF3F O00303 MKRN2 Homo sapiens Q9H000
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
EIF3F O00303 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
EIF3F O00303 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
EIF3F O00303 FAM222B Homo sapiens Q8WU58
Validated Y2H
32296183
Intra
EIF3F O00303 NUP58 Homo sapiens Q9BVL2
Y2H Pooling
32814053
Intra
EIF3F O00303 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32814053
Intra
EIF3F O00303 NUP58 Homo sapiens Q9BVL2
Y2H Array
32814053
Intra
EIF3F O00303 FBXO32 Homo sapiens Q969P5
Pull Down
18354498
Intra
EIF3F O00303 FBXO32 Homo sapiens Q969P5
Y2H
18354498
Intra
EIF3F O00303 FBXO32 Homo sapiens Q969P5
Anti Tag CoIP
18354498
Intra
EIF3F O00303 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
EIF3F O00303 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
EIF3F O00303 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
Pull Down
23623729
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
Anti Tag CoIP
33961781
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
Anti Tag CoIP
28514442
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
MAPPIT
25416956
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
Anti Tag CoIP
18599441
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
SLCA
19748344
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
Y2H Array
32296183
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
SLCA
18599441
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
Y2H Pooling
16169070
Intra
EIF3F O00303 EIF3M Homo sapiens Q7L2H7
Validated Y2H
32296183
Intra
EIF3F O00303 RIN1 Homo sapiens Q13671
Validated Y2H
32296183
Intra
EIF3F O00303 EIF3B Homo sapiens P55884
Anti Tag CoIP
33961781
Intra
EIF3F O00303 EIF3B Homo sapiens P55884
Anti Tag CoIP
24396066
Intra
EIF3F O00303 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
EIF3F O00303 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
EIF3F O00303 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
EIF3F O00303 SUOX Homo sapiens P51687
Validated Y2H
32296183
Intra
EIF3F O00303 CYCS Homo sapiens P99999
Y2H Pooling
32814053
Intra
EIF3F O00303 CYCS Homo sapiens P99999
Validated Y2H
32814053
Intra
EIF3F O00303 CYCS Homo sapiens P99999
Y2H Array
32814053
Intra
EIF3F O00303 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra
EIF3F O00303 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra
EIF3F O00303 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra
EIF3F O00303 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
EIF3F O00303 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
EIF3F O00303 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
EIF3F O00303 PKN1 Homo sapiens Q16512
Validated Y2H
32296183
Intra
EIF3F O00303 MSH4 Homo sapiens O15457
Anti Tag CoIP
23725059
Cross
EIF3F O00303 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra
EIF3F O00303 EIF3H Homo sapiens O15372
SLCA
19748344
Intra
EIF3F O00303 EIF3H Homo sapiens O15372
SLCA
18599441
Intra
EIF3F O00303 EIF3H Homo sapiens O15372
Anti Tag CoIP
33961781
Intra
EIF3F O00303 EIF3H Homo sapiens O15372
Anti Tag CoIP
28514442
Intra
EIF3F O00303 EIF3H Homo sapiens O15372
Pull Down
23623729
Intra
EIF3F O00303 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 AGR2 Homo sapiens O95994
Validated Y2H
32296183
Intra
EIF3F O00303 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
EIF3F O00303 RABIF Homo sapiens P47224
Validated Y2H
32296183
Intra
EIF3F O00303 MYDGF Homo sapiens Q969H8
Validated Y2H
32296183
Intra
EIF3F O00303 CASP6 Homo sapiens P55212
Y2H Pooling
32814053
Intra
EIF3F O00303 CASP6 Homo sapiens P55212
Validated Y2H
32814053
Intra
EIF3F O00303 CASP6 Homo sapiens P55212
Y2H Array
32814053
Intra
EIF3F O00303 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
EIF3F O00303 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
EIF3F O00303 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
EIF3F O00303 HGS Homo sapiens O14964
Validated Y2H
32296183
Intra
EIF3F O00303 NUP54 Homo sapiens Q7Z3B4
Validated Y2H
32296183
Intra
EIF3F O00303 MYOZ1 Homo sapiens Q9NP98
Validated Y2H
32296183
Intra
EIF3F O00303 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
EIF3F O00303 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
EIF3F O00303 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
EIF3F O00303 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
EIF3F O00303 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
EIF3F O00303 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
EIF3F O00303 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
EIF3F O00303 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
EIF3F O00303 COL1A2 Homo sapiens P08123
Y2H Prey Pooling
32296183
Intra
EIF3F O00303 COL1A2 Homo sapiens P08123
Validated Y2H
32296183
Intra
EIF3F O00303 COL1A2 Homo sapiens P08123
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Recessive 67

MRT67

Mental Retardation, Autosomal Recessive 67

Autosomal Recessive Intellectual Developmental Disorder 67
Syndromic Intellectual Disability
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04262 EIF3F Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EIF3F VGNC VGNC:82013
Mus musculus EIF3F MGD MGI:1913335
Macaca mulatta EIF3F VGNC VGNC:72191
Rattus norvegicus EIF3F RGD RGD:1306112
Bos taurus EIF3F VGNC VGNC:28396
Canis familiaris EIF3F VGNC VGNC:40272
Others EIF3F NCBI