MSN - moesin Gene

Homo sapiens

Also known as HEL70; IMD50

Gene ID: 4478 | Gene type: protein coding

About MSN

Cytogenetic location: Xq12 Genomic coordinates (GRCh38): X:65,588,377-65,741,931 (from NCBI)

This gene has 16 transcripts (splice variants), 283 orthologues, 6 paralogues and is associated with 76 phenotypes. Ubiquitous expression in lung (RPKM 147.3), appendix (RPKM 142.6) and 24 other tissues.

Summary

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and Other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

MSN Products(1)

mRNA	Protein	Name
NM_002444.3	NP_002435.1	moesin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12082081	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15922359	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7844168	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19255442	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	15819698	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell aggregation	IDA IDA: Inferred from direct assay	27405666	GOA
involved in T cell migration	IDA IDA: Inferred from direct assay	27405666	GOA
involved in T cell proliferation	IDA IDA: Inferred from direct assay	27405666	GOA
involved in cellular response to testosterone stimulus	IDA IDA: Inferred from direct assay	24065547	GOA
involved in establishment of endothelial barrier	IGI IGI: Inferred from genetic interaction	23264465	GOA
involved in establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	24862762	GOA
involved in gland morphogenesis	IMP IMP: Inferred from mutant phenotype	24862762	GOA
involved in immunological synapse formation	IDA IDA: Inferred from direct assay	27405666	GOA
involved in leukocyte cell-cell adhesion	IEP IEP: Inferred from expression pattern	12082081	GOA
involved in leukocyte migration	IEP IEP: Inferred from expression pattern	12082081	GOA
involved in membrane to membrane docking	IEP IEP: Inferred from expression pattern	12082081	GOA
involved in positive regulation of early endosome to late endosome transport	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	23264465	GOA
involved in positive regulation of protein catabolic process	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in positive regulation of protein localization to early endosome	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	24862762	GOA
NOT involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	22467863	GOA
involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	24862762	GOA
involved in regulation of lymphocyte migration	IMP IMP: Inferred from mutant phenotype	19255442	GOA
involved in regulation of organelle assembly	IGI IGI: Inferred from genetic interaction	21148287	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	12082081	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	24862762	GOA
located in cell periphery	IDA IDA: Inferred from direct assay	22291017	GOA
located in cell surface	IDA IDA: Inferred from direct assay	15922359	GOA
located in filopodium	IDA IDA: Inferred from direct assay	12082081	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	21282464	GOA
located in microvillus	IDA IDA: Inferred from direct assay	12082081	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	24862762	GOA
located in pseudopodium	IDA IDA: Inferred from direct assay	24065547	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSN Protein Structure

FERM_N

FERM_M

FERM_C

ERM

0
100
200
300
400
500
577 a.a.

Protein Preferred Names

Protein Names

moesin

epididymis luminal protein 70

MSN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MSN	P26038	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	MSN	P26038	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Cross	MSN	P26038	Lrrk2	Mus musculus	Q5S006	Protein Kinase Assay	24794857
Intra	MSN	P26038	NHERF1	Homo sapiens	O14745	Pull Down	9430655
Intra	MSN	P26038	NHERF1	Homo sapiens	O14745	Affinity Chrom	15020681
Intra	MSN	P26038	NHERF1	Homo sapiens	O14745	X-Ray Diffraction	15020681
Intra	MSN	P26038	NHERF1	Homo sapiens	O14745	IF	9430655
Intra	MSN	P26038	CD44	Homo sapiens	P16070	Anti Bait CoIP	23855374
Intra	MSN	P26038	CD44	Homo sapiens	P16070	Confocal	23855374
Intra	MSN	P26038	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	24351927
Intra	MSN	P26038	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	24695735
Intra	MSN	P26038	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	23241358
Intra	MSN	P26038	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	MSN	P26038	TERF1	Homo sapiens	P54274	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MSN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73806	Moesin Protein, Human (His)	P26038 (M1-E346)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 50

Combined Immunodeficiency Due To Moesin Deficiency	IMD50
Immunodeficiency 50, X-Linked Recessive	Cid Due To Moesin Deficiency
Msn-Related Combined Immunodeficiency	X-Linked Moesin-Associated Immunodeficiency
Immunodeficiency 50 X Linked Recessive

Verrucous Carcinoma

Verrucous Squamous Carcinoma	Verrucous Squamous Cell Carcinoma
Warty Carcinoma	Carcinoma Verrucous
Carcinoma, Verrucous

Acoustic Neuroma

Neurofibromatosis Type 2	Vestibular Schwannoma
Acoustic Neurinoma	Bilateral Acoustic Neurofibromatosis
Nf2	Acoustic Neurilemoma
Cerebellopontine Angle Tumor	Neurofibromatosis Central Type
Neurofibromatosis Type Ii	Vestibular Neurilemmoma
Acoustic Tumor	Neurinoma Of The Acoustic Nerve
Acoustic Neurinoma Bilateral	Acoustic Schwannomas Bilateral
Banf	Central Neurofibromatosis
Familial Acoustic Neuromas	Neurofibromatosis 2
Neurofibromatosis Type 2 Merlin	Schwannoma, Acoustic, Bilateral
Neuroma Acoustic	Neuroma, Acoustic
Familial Acoustic Neuroma	Familial Vestibular Schwannoma
Neurofibromatosis, Central Type	Nf2 - [Neurofibromatosis Type 2]

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Neurilemmoma

Schwannoma	Benign Schwannoma
Neurilemoma	Peripheral Fibroblastoma
Psammomatous Schwannoma	Neurolemmoma
Schwannomas

Kindler Syndrome

Poikiloderma Of Kindler	Bullous Acrokeratotic Poikiloderma Of Kindler And Weary
Congenital Bullous Poikiloderma	KNDLRS
Poikiloderma, Hereditary Acrokeratotic	Poikiloderma, Congenital, With Bullae, Weary Type
Kindler'S Syndrome	Poikiloderma Congenital With Bullae Weary Type
Hereditary Acrokeratotic Poikiloderma Of Kindler-Weary	Hereditary Acrokeratotic Poikiloderma
Weary Syndrome	Poikiloderma Hereditary Acrokeratotic
Potassium Deficiency

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Anaplastic Large Cell Lymphoma

Alcl	Cd30 Positive Anaplastic Large Cell Lymphoma
Ki-1 Positive Anaplastic Large Cell Lymphoma	Primary Systemic Alcl
Sacl	Ki-1+ Anaplastic Large Cell Lymphoma

Polyarteritis Nodosa

Polyarteritis	Periarteritis Nodosa
Pan	Periarteritis
Kussmaul-Maier Disease	Panarteritis Nodosa
Kussmaul Disease	Pan - [Polyarteritis Nodosa]
Polyangiitis	Panangiitis
Arteritis Nodosa

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Neurofibromatosis

Neurofibromatoses	Acoustic Neurofibromatosis
Central Neurofibromatosis	Peripheral Neurofibromatosis
Recklinghausen'S Neurofibromatosis	Von Reklinghausen Disease
Neurofibromatosis Type 1

Deafness, Autosomal Recessive 24

DFNB24	Deafness, Autosomal Recessive, 24
Autosomal Recessive Nonsyndromic Deafness 24	Autosomal Recessive Deafness 24
Deafness, Autosomal Recessive, Type 24

Leukocyte Adhesion Deficiency, Type Iii

Leukocyte Adhesion Deficiency 3	LAD3
Leukocyte Adhesion Deficiency 1 Variant	Lad1v
Integrin Activation Deficiency Disease	Iadd
Leukocyte Adhesion Deficiency Type Iii	Lad1 Variant
Lad-1 Variant	Lad-Iii
Leukocyte Adhesion Deficiency-1 Variant	Leukocyte Adhesion Deficiency Type 1

Optic Nerve Sheath Meningioma

Meningioma Of Optic Nerve Sheath

Petrous Apex Meningioma

Meningioma Of The Petrous Ridge

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12646	Rhosin hydrochloride		99.93%	Unkown
HY-120079	MSN-125	Inhibitor	99.00%	Unkown
HY-118948	MSN-50	Inhibitor	98.68%	Unkown
HY-149410	MSN8C	Inhibitor	/	Unkown
HY-RS08723	MSN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-12646A	Rhosin		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MSN	VGNC	VGNC:68328
Mus musculus	MSN	MGD	MGI:97167
Rattus norvegicus	MSN	RGD	RGD:621260
Macaca mulatta	MSN	VGNC	VGNC:74938
Canis familiaris	MSN	VGNC	VGNC:43447
Bos taurus	MSN	VGNC	VGNC:31703
Others	MSN	NCBI

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