RGS20 - regulator of G protein signaling 20 Gene

Homo sapiens

Also known as RGSZ1; ZGAP1; gz-GAP; g(z)GAP

Gene ID: 8601 | Gene type: protein coding

About RGS20

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,851,795-53,959,304 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues and 23 paralogues. Biased expression in brain (RPKM 2.5), thyroid (RPKM 0.6) and 3 other tissues.

Summary

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

RGS20 Products(5)

mRNA	Protein	Name
NM_001286673.2	NP_001273602.1	regulator of G-protein signaling 20 isoform c
NM_001286674.2	NP_001273603.1	regulator of G-protein signaling 20 isoform d
NM_001286675.2	NP_001273604.1	regulator of G-protein signaling 20 isoform e
NM_003702.4	NP_003693.2	regulator of G-protein signaling 20 isoform b
NM_170587.4	NP_733466.1	regulator of G-protein signaling 20 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20859254	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	10791963	GOA
located in trans-Golgi network	IMP IMP: Inferred from mutant phenotype	10791963	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS20 Protein Structure

RGS

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 20

gz-selective GTPase-activating protein

RGS20 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RGS20	O76081	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	RGS20	O76081	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	RGS20	O76081	CREB5	Homo sapiens	Q02930-3	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	PTGER3	Homo sapiens	P43115-12	Validated Y2H	25416956
Intra	RGS20	O76081	LCE3E	Homo sapiens	Q5T5B0	Validated Y2H	25416956
Intra	RGS20	O76081	LCE3E	Homo sapiens	Q5T5B0	Y2H Array	25416956
Intra	RGS20	O76081	LCE3E	Homo sapiens	Q5T5B0	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	LCE1B	Homo sapiens	Q5T7P3	Y2H Array	29892012
Intra	RGS20	O76081	LCE1B	Homo sapiens	Q5T7P3	Y2H Array	31515488
Intra	RGS20	O76081	LCE1B	Homo sapiens	Q5T7P3	Validated Y2H	25416956
Intra	RGS20	O76081	LCE1B	Homo sapiens	Q5T7P3	Y2H Array	25416956
Intra	RGS20	O76081	LCE4A	Homo sapiens	Q5TA78	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	LCE4A	Homo sapiens	Q5TA78	Y2H Array	25416956
Intra	RGS20	O76081	LCE2D	Homo sapiens	Q5TA82	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	LCE2D	Homo sapiens	Q5TA82	Y2H Array	25416956
Intra	RGS20	O76081	q9nwl9_human	Homo sapiens	Q9NWL9	Y2H Array	25416956
Intra	RGS20	O76081	MTNR1A	Homo sapiens	P48039	BRET	20859254
Intra	RGS20	O76081	MTNR1A	Homo sapiens	P48039	Pull Down	20859254
Intra	RGS20	O76081	MTNR1A	Homo sapiens	P48039	Anti Tag CoIP	20859254
Intra	RGS20	O76081	MTNR1B	Homo sapiens	P49286	Anti Tag CoIP	20859254
Intra	RGS20	O76081	NECTIN3	Homo sapiens	Q9NQS3	Validated Y2H	25416956
Intra	RGS20	O76081	HSPD1	Homo sapiens	P10809	Validated Y2H	25416956
Intra	RGS20	O76081	HSPD1	Homo sapiens	P10809	Y2H Array	25416956
Intra	RGS20	O76081	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	RGS20	O76081	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	33961781
Intra	RGS20	O76081	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	RGS20	O76081	GLRX3	Homo sapiens	O76003	Y2H Array	29892012
Intra	RGS20	O76081	GLRX3	Homo sapiens	O76003	Anti Bait CoIP	17353931
Cross	RGS20	O76081	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Cross	RGS20	O76081	Hoxa1	Mus musculus	P09022	Y2H	23088713
Intra	RGS20	O76081	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	RGS20	O76081	KLHL38	Homo sapiens	Q2WGJ6	Y2H Array	25416956
Intra	RGS20	O76081	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	25416956
Intra	RGS20	O76081	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	25416956
Intra	RGS20	O76081	CRCT1	Homo sapiens	Q9UGL9	Y2H Array	25416956
Intra	RGS20	O76081	OTX1	Homo sapiens	P32242	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	HOXA1	Homo sapiens	P49639	Validated Y2H	25416956
Intra	RGS20	O76081	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	HOXA1	Homo sapiens	P49639	Y2H Array	25416956
Intra	RGS20	O76081	HOXA1	Homo sapiens	P49639	Y2H Array	31515488
Intra	RGS20	O76081	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	25416956
Intra	RGS20	O76081	AQP1	Homo sapiens	P29972	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	MAPKBP1	Homo sapiens	O60336	Y2H Prey Pooling	25416956
Intra	RGS20	O76081	MAPKBP1	Homo sapiens	O60336	Validated Y2H	25416956
Intra	RGS20	O76081	MAPKBP1	Homo sapiens	O60336	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11917	RGS20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RGS20	MGD	MGI:1929866
Macaca mulatta	RGS20	VGNC	VGNC:76735
Rattus norvegicus	RGS20	RGD	RGD:1586146
Bos taurus	RGS20	VGNC	VGNC:33919
Canis familiaris	RGS20	VGNC	VGNC:45530

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