MX1 - MX dynamin like GTPase 1 Gene

Homo sapiens

Also known as MX; MxA; IFI78; IFI-78K; lncMX1-215

Gene ID: 4599 | Gene type: protein coding

About MX1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,420,558-41,459,214 (from NCBI)

This gene has 48 transcripts (splice variants), 196 orthologues and 6 paralogues. Ubiquitous expression in spleen (RPKM 25.6), salivary gland (RPKM 13.5) and 24 other tissues.

Summary

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular Antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

MX1 Products(4)

mRNA	Protein	Name
NM_001144925.2	NP_001138397.1	interferon-induced GTP-binding protein Mx1 isoform a
NM_001178046.3	NP_001171517.1	interferon-induced GTP-binding protein Mx1 isoform a
NM_001282920.1	NP_001269849.1	interferon-induced GTP-binding protein Mx1 isoform b
NM_002462.5	NP_002453.2	interferon-induced GTP-binding protein Mx1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20428112	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15047845	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IEP IEP: Inferred from expression pattern	25930096	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in interleukin-27-mediated signaling pathway	IEP IEP: Inferred from expression pattern	32270034	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	14687945	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	15047845	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21859714	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15047845	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MX1 Protein Structure

Dynamin_N

Dynamin_M

GED

0
200
400
600
662 a.a.

Protein Preferred Names

Protein Names

interferon-induced GTP-binding protein Mx1

interferon-induced protein p78

Related Diseases

Diseases

Alias

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Viral Encephalitis

Epidemic Encephalitis	Encephalitis Viral
Encephalitis, Arbovirus	Arbovirus Encephalitis
Postviral Encephalitis Nos	Equine Encephalitis
Tick-Borne Encephalitis	Viral Encephalitis Transmitted By Tick
Mosquito-Borne Encephalitis	Acute Haemorrhagic Encephalitis
Acute Idiopathic Encephalitis	Chronic Viral Encephalitis
Endemic Encephalitis	Subacute Viral Encephalitis
Viral Haemorrhagic Encephalitis	Viral Nonepidemic Encephalitis
Nonepidemic Encephalitis

Subacute Sclerosing Panencephalitis

SSPE	Dawson Encephalitis
Immunosuppressive Measles Encephalitis	Subacute Sclerosing Leukoencephalitis
Panencephalitis, Subacute Sclerosing	Subacute Sclerosing Leukoencephalopathy
Van Bogaert'S Sclerosing Leukoencephalitis	Dawson Disease
Subacute Inclusion Body Encephalitis	Van Bogaert Disease
Van Bogaert Encephalitis	Measles Inclusion Body Encephalitis
Mibe - [Measles Inclusion Body Encephalitis]	Sspe - [Subacute Sclerosing Panencephalitis]
Van Bogaert Leukoencephalitis	Van Bogaert Sclerosing Leukoencephalitis
Dawson Inclusion Body Encephalitis	Van Bogaert Sclerosing Leukoencephalopathy
Bodechtel Guttman Disease	Diffuse Sclerosing Encephalitis

Lichen Planus

Lichen Ruber Planus	Lichen, Ruber Planus
Ruber Planus	Lp - [Lichen Planus]
Lichen Planus Of Wilson	Wilson Lichen Ruber

Biliary Atresia

Congenital Biliary Atresia	Isolated Biliary Atresia
Isolated Atresia Of Bile Ducts	Non-Syndromic Biliary Atresia
Atresia Of Bile Duct	Biliary Atresia, Congenital
Atresia Of Bile Ducts	Bile Duct Atresia
Congenital Bile Duct Atresia	Ba - [Biliary Atresia]
Impervious Bile Duct	Atresia Of Common Duct
Biliary Duct Atresia	Bile Ductal Atresia
Cystic Duct Atresia

Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms	Relapsing Remitting Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting	Rrms
Multiple Sclerosis Relapsing-Remitting

Pityriasis Lichenoides

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Viral Hepatitis

Animal Viral Hepatitis	Hepatitis, Viral, Animal
Human Viral Hepatitis	Viral Hepatitis With Hepatic Coma

Rift Valley Fever

Rfv - [Rift Valley Fever]

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Cowpox

Yaba

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Acute Generalized Exanthematous Pustulosis

Agep	Pustular Drug Eruption
Toxic Pustuloderma

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

Mouth Disease

Mouth Diseases

Mouth Disorders

Severe Acute Respiratory Syndrome

Sars	Sars-Cov Infection
Sars-1	Sar Deficiency
Sars - [Severe Acute Respiratory Syndrome]

Stomatitis

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Hantavirus Hemorrhagic Fever With Renal Syndrome

Hemorrhagic Fever, Russian	Hemorrhagic Nephrosonephritis
Hfrs	Puumala Virus Nephropathy
Hemorrhagic Fever With Renal Syndrome

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Scrapie

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Pediculus Humanus Corporis Infestation

Body Louse Infestation	Pediculus Corporis
Pediculus Humanus Infestation

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic	JMML
Leukemia, Juvenile Myelomonocytic, Somatic	Juvenile Chronic Myelomonocytic Leukemia
Juvenile Chronic Myelogenous Leukemia	Leukemia, Myelomonocytic, Juvenile
Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12098	Verubulin hydrochloride	Inhibitor	98.71%	Phase 2
HY-106031	F-14512		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0167	Gynostemma Extract		99.92%	Unkown
HY-123805	KIN1400		98.1%	Unkown
HY-155113	PROTAC Hsp90α degrader 1	Degrader	/	Unkown
HY-RS08859	MX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121372	Lactandrate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MX1	VGNC	VGNC:31770
Macaca mulatta	MX1	VGNC	VGNC:75086
Canis familiaris	MX1	VGNC	VGNC:43511
Rattus norvegicus	MX1	RGD	RGD:3127
Felis catus	MX1	VGNC	VGNC:108368
Others	MX1	NCBI