2. Gene
  3. ATF1 - activating transcription factor 1 Gene

ATF1 - activating transcription factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TREB36; EWS-ATF1; FUS/ATF-1

Gene ID: 466 | Gene type: protein coding

About ATF1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,763,459-50,821,162 (from NCBI)

This gene has 5 transcripts (splice variants), 148 orthologues, 9 paralogues and is associated with 66 phenotypes. Ubiquitous expression in thyroid (RPKM 6.8), adrenal (RPKM 5.9) and 25 other tissues.

Summary

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

ATF1 Products(25)

mRNA Protein Name
NM_001412960.1 NP_001399889.1 cyclic AMP-dependent transcription factor ATF-1 isoform a
NM_001412961.1 NP_001399890.1 cyclic AMP-dependent transcription factor ATF-1 isoform b
NM_001412962.1 NP_001399891.1 cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412963.1 NP_001399892.1 cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412964.1 NP_001399893.1 cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412965.1 NP_001399894.1 cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412966.1 NP_001399895.1 cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412967.1 NP_001399896.1 cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412968.1 NP_001399897.1 cyclic AMP-dependent transcription factor ATF-1 isoform d
NM_001412969.1 NP_001399898.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412970.1 NP_001399899.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412971.1 NP_001399900.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412972.1 NP_001399901.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412973.1 NP_001399902.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412974.1 NP_001399903.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412975.1 NP_001399904.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412976.1 NP_001399905.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412977.1 NP_001399906.1 cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412978.1 NP_001399907.1 cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412979.1 NP_001399908.1 cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412980.1 NP_001399909.1 cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412981.1 NP_001399910.1 cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412982.1 NP_001399911.1 cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412983.1 NP_001399912.1 cyclic AMP-dependent transcription factor ATF-1 isoform g
NM_005171.5 NP_005162.1 cyclic AMP-dependent transcription factor ATF-1 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
1655749 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1655749 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10722738 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
25644539 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
1655749 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
1655749 GOA
involved in response to purine-containing compound IDA
IDA: Inferred from direct assay
25644539 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ATF1-ATF4 transcription factor complex IDA
IDA: Inferred from direct assay
12871976 GOA
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
20102225 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8798441 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF1 Protein Structure

pKID

pKID: pKID domain (43 - 82)

bZIP_1

bZIP_1: bZIP transcription factor (212 - 268)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-1

cAMP-dependent transcription factor ATF-1

Recombinant ATF1 Proteins

Cat. No. Product Name Accession Purity
HY-P7615 ATF1 Protein, Human (His) P18846 (M1-V271) ≥95%

Related Diseases

Diseases Alias
Melanoma Of Soft Tissue

Clear Cell Sarcoma Of The Tendons And Aponeuroses
Fibrous Histiocytoma

Benign Fibrous Histiocytoma

Histiocytoma, Benign Fibrous

Fibroxanthoma

Histiocytoma Fibrous
Clear Cell Sarcoma

Sarcoma, Clear Cell

Adult Soft Part Clear Cell Sarcoma

Clear Cell Sarcoma Of Soft Parts

Malignant Melanoma Of Soft Parts

Malignant Melanoma Of Soft Tissues

Melanoma, Malignant, Of Soft Parts

Sarcoma Clear Cell
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma

Liposarcoma, Myxoid

Mrcls

Myxoliposarcoma

MXLIPO

Liposarcoma Myxoid

Liposarcoma
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Myxoid Chondrosarcoma
Sarcomatosis
Alveolar Soft Part Sarcoma

ASPS

Alveolar Soft-Part Sarcoma

Sarcoma, Alveolar Soft Part

Alveolar Soft Tissue Sarcoma

Sarcoma Alveolar Soft Part

Adult Alveolar Soft-Part Sarcoma

Childhood Alveolar Soft-Part Sarcoma
Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma

Emc

Myxoid Extraosseous Chondrosarcoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108618 BC11-38 Inhibitor 99.42% Unkown
HY-N12887 Mycothiazole Inhibitor / Unkown
HY-RS01127 ATF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ATF1 VGNC VGNC:38207
Rattus norvegicus ATF1 RGD RGD:1307360
Felis catus ATF1 VGNC VGNC:83504
Macaca mulatta ATF1 VGNC VGNC:108325
Mus musculus ATF1 MGD MGI:1298366
Bos taurus ATF1 VGNC VGNC:26239
Others ATF1 NCBI