NFIL3 - nuclear factor, interleukin 3 regulated Gene

Homo sapiens

Also known as E4BP4; IL3BP1; NFIL3A; NF-IL3A

Gene ID: 4783 | Gene type: protein coding

About NFIL3

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:91,409,045-91,483,497 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 59.6), adrenal (RPKM 37.4) and 23 other tissues.

Summary

The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

NFIL3 Products(3)

mRNA	Protein	Name
NM_001289999.2	NP_001276928.1	nuclear factor interleukin-3-regulated protein
NM_001290000.2	NP_001276929.1	nuclear factor interleukin-3-regulated protein
NM_005384.3	NP_005375.2	nuclear factor interleukin-3-regulated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1620116	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1620116	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20093779	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1620116	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20093779	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFIL3 Protein Structure

bZIP_2

Vert_IL3-reg_TF

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

nuclear factor interleukin-3-regulated protein

E4 promoter-binding protein 4

NFIL3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFIL3	Q16649	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	NFIL3	Q16649	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	NFIL3	Q16649	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	NFIL3	Q16649	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	NFIL3	Q16649	PDE9A	Homo sapiens	O76083-2	Y2H Prey Pooling	32296183
Intra	NFIL3	Q16649	PDE9A	Homo sapiens	O76083-2	Y2H Array	32296183
Intra	NFIL3	Q16649	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	NFIL3	Q16649	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	NFIL3	Q16649	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	NFIL3	Q16649	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	NFIL3	Q16649	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	NFIL3	Q16649	ATF1	Homo sapiens	P18846	Peptide Array	20102225
Intra	NFIL3	Q16649	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	NFIL3	Q16649	NFIL3	Homo sapiens	Q16649	Peptide Array	20102225
Intra	NFIL3	Q16649	NFIL3	Homo sapiens	Q16649	FRET	23661758
Intra	NFIL3	Q16649	ATF1	Homo sapiens	P18846	Anti Tag CoIP	28514442
Intra	NFIL3	Q16649	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	NFIL3	Q16649	CREB1	Homo sapiens	P16220	Peptide Array	20102225
Intra	NFIL3	Q16649	NFIL3	Homo sapiens	Q16649	Peptide Array	12805554
Intra	NFIL3	Q16649	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	NFIL3	Q16649	AMOTL2	Homo sapiens	Q9Y2J4	Y2H	21516116
Intra	NFIL3	Q16649	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	NFIL3	Q16649	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	NFIL3	Q16649	MAFG	Homo sapiens	O15525	FRET	23661758
Intra	NFIL3	Q16649	MAFF	Homo sapiens	Q9ULX9	FRET	23661758
Intra	NFIL3	Q16649	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	32296183
Intra	NFIL3	Q16649	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	NFIL3	Q16649	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Zebrafish Allergy

Danio Rerio Allergy

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09252	NFIL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFIL3	MGD	MGI:109495
Bos taurus	NFIL3	VGNC	VGNC:32041
Rattus norvegicus	NFIL3	RGD	RGD:620972
Felis catus	NFIL3	VGNC	VGNC:68478
Canis familiaris	NFIL3	VGNC	VGNC:43778
Macaca mulatta	NFIL3	VGNC	VGNC:75337

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