NFATC1 - nuclear factor of activated T cells 1 Gene

Homo sapiens

Also known as NFAT2; NFATc; NF-ATC; NF-ATc1.2

Gene ID: 4772 | Gene type: protein coding

About NFATC1

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:79,395,930-79,529,323 (from NCBI)

This gene has 18 transcripts (splice variants), 265 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 7.4), spleen (RPKM 6.0) and 24 other tissues.

Summary

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

NFATC1 Products(10)

mRNA	Protein	Name
NM_001278669.2	NP_001265598.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform F
NM_001278670.2	NP_001265599.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform G
NM_001278672.2	NP_001265601.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform H
NM_001278673.2	NP_001265602.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform J
NM_001278675.2	NP_001265604.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform I
NM_006162.5	NP_006153.2	nuclear factor of activated T-cells, cytoplasmic 1 isoform B
NM_172387.3	NP_765975.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform C
NM_172388.3	NP_765976.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform D
NM_172389.3	NP_765977.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform E
NM_172390.3	NP_765978.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nucleic acid binding	EXP EXP: Inferred from Experiment	8990122	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17882263	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	14979875	GOA
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	14749367	GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	23853098	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14749367	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14979875	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14979875	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	14979875	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	15304486	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12370307	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFATC1 Protein Structure

RHD_DNA_bind

TIG

0
200
400
600
800
943 a.a.

Protein Preferred Names

Protein Names

nuclear factor of activated T-cells, cytoplasmic 1

NFAT transcription complex cytosolic component

NFATC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFATC1	O95644	ATF2	Homo sapiens	P15336	TAP	25609649
Intra	NFATC1	O95644	HOXC13	Homo sapiens	P31276	TAP	25609649
Intra	NFATC1	O95644	OGT	Homo sapiens	O15294	Anti Bait CoIP	17882263
Intra	NFATC1	O95644	CREB1	Homo sapiens	P16220	TAP	25609649
Intra	NFATC1	O95644	ATF3	Homo sapiens	P18847	TAP	25609649
Intra	NFATC1	O95644	ATF1	Homo sapiens	P18846	TAP	25609649
Intra	NFATC1	O95644	JUN	Homo sapiens	P05412	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

NFATC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80243	NFAT2 Antibody	WB, IHC-P, FC	Human
HY-P81644	Phospho-NFAT2 (Ser237) Antibody (YA1389)	WB	Human, Mouse

Related Diseases

Diseases

Alias

Tricuspid Atresia

Congenital Agenesis Of The Tricuspid Valve

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

Osteonecrosis

Bone Necrosis	Avascular Necrosis Of Bone
Aseptic Necrosis	Necrosis Of Bone Nos
Aseptic Osteonecrosis	Aseptic Necrosis Of Bone, Site Unspecified
Aseptic Or Avascular Bone Necrosis	Aseptic Necrosis Of Bone
Necrotic Bone	Necrotizing Bone
Spontaneous Osteonecrosis	Osteoradionecrosis

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Osteonecrosis Of The Jaw

Colitis

Osteomyelitis

Bone Epithelioid Hemangioma

Bone Hemangioma	Hemangioma Of Bone
Osseous Epithelioid Hemangioma	Osseous Hemangioma

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Leukostasis

Bone Remodeling Disease

Osteopetrosis, Autosomal Recessive 2

OPTB2	Autosomal Recessive Osteopetrosis 2
Osteopetrosis, Mild Autosomal Recessive Form	Osteoclast-Poor Osteopetrosis
Osteopetrosis, Osteoclast-Poor	Mild Autosomal Recessive Form Osteopetrosis
Osteopetrosis Autosomal Recessive 2	Autosomal Recessive Osteopetrosis Type 2
Osteopetrosis Osteoclast-Poor	Osteopetrosis, Autosomal Recessive, Type 2

Metatropic Dysplasia

Metatropic Dwarfism	MTD
Metatropic Dysplasia Type 1	Metatropic Dysplasia, Nonlethal Dominant

Bone Resorption Disease

Bone Resorption

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Chronic Apical Periodontitis

Apical Periodontitis Nos	Apex Periodontitis
Periapical Infection Nos

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Glucocorticoid-Induced Osteoporosis

Steroid-Induced Osteoporosis

Familial Expansile Osteolysis

FEO	Mccabe Disease
Osteolysis, Familial Expansile	Polyostotic Osteolytic Dysplasia, Hereditary Expansile
Hepod	Expansile Osteolysis, Familial
Eof	Hereditary Expansile Polyostotic Osteolytic Dysplasia

Ischemic Bone Disease

Endosteal Hyperostosis, Autosomal Dominant

Osteosclerosis	Worth Syndrome
Osteosclerosis, Autosomal Dominant	Hyperostosis, Endosteal
Endosteal Hyperostosis, Worth Type	Worth Disease
Autosomal Dominant Endosteal Hyperostosis	Autosomal Dominant Osteosclerosis, Worth Type
Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus	Autosomal Dominant Osteosclerosis
Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus	Worth'S Syndrome
Worth Type Autosomal Dominant Osteosclerosis	Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus
Osteosclerosis, Autosomal Dominant, Worth Type	WENHY
Endosteal Hyperostosis Autosomal Dominant	Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus
Osteosclerosis Autosomal Dominant	Acquired Osteosclerosis

Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis	Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus
LPHDST	Distichiasis-Lymphedema Syndrome
Lymphedema Distichiasis Syndrome	Hereditary Lymphedema-Distichiasis Syndrome
Lymphedema Distichiasis

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Atrioventricular Septal Defect

AVSD	Atrioventricular Canal Defect
Avcd	Endocardial Cushion Defect
Ecd	Avc Defect
Atrioventricular Septal Defect, Susceptibility To, 1	Atrioventricular Septal Defect 1
Endocardial Cushion Defects	Septal Defect, Atrioventricular
Atrioventricular Defect With Atrial Shunting Only	Incomplete Atrioventricular Septal Defect With Isolated Atrial Component
Incomplete Atrioventricular Canal Defect With Isolated Atrial Component	Primum Atrial Septal Defect
Partial Atrioventricular Canal Defect With Isolated Atrial Component	Partial Atrioventricular Septal Defect, Ostium Primum Type
Ostium Primum Atrial Septal Defect	Partial Atrioventricular Canal Defect
Partial Atrioventricular Septal Defect	Atrial Septum Primum Defect
Atrioventricular Canal Defect With Isolated Ventricular Component	Atrioventricular Canal Defect With Isolated Ventricular Communication
Atrioventricular Septal Defect With Isolated Ventricular Component	Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting
Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve	Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves
Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect	Intermediate Atrioventricular Canal Defect
Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices	Intermediate Atrioventricular Septal Defect
Transitional Atrioventricular Canal Defect	Transitional Atrioventricular Septal Defect
Complete Atrioventricular Canal With Atrial And Ventricular Components	Complete Atrioventricular Canal Defect
Complete Atrioventricular Septal Defect

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Myopathy

Muscular Diseases

Myopathies

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113756A	Latanoprost acid	Inhibitor	99.62%	Unkown

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0656	Usnic acid	Inhibitor	98.90%	Unkown
HY-N2119	Sciadopitysin	Inhibitor	99.19%	Unkown
HY-147369	NFATc1-IN-1	Inhibitor	99.65%	Unkown
HY-N0231	Bavachalcone		99.95%	Unkown
HY-123503	Salicortin	Inhibitor	/	Unkown
HY-124958	NDMC101	Inhibitor	99.91%	Unkown
HY-149852	Anti-osteoporosis agent-3		/	Unkown
HY-162280	PROTAC BTK Degrader-9		/	Unkown
HY-N12604	Penicisteck acid F	Inhibitor	/	Unkown
HY-N2528	Usnic acid sodium	Inhibitor	/	Unkown
HY-N3071	Picrasidine I		/	Unkown
HY-P4684	Osteostatin		/	Unkown
HY-RS09238	NFATC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W641445	ELP-004	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFATC1	MGD	MGI:102469
Macaca mulatta	NFATC1	VGNC	VGNC:75326
Bos taurus	NFATC1	VGNC	VGNC:32030
Rattus norvegicus	NFATC1	RGD	RGD:2319357
Felis catus	NFATC1	VGNC	VGNC:68469
Canis familiaris	NFATC1	VGNC	VGNC:43766
Others	NFATC1	NCBI