2. Gene
  3. HNRNPM - heterogeneous nuclear ribonucleoprotein M Gene

HNRNPM - heterogeneous nuclear ribonucleoprotein M Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M

Gene ID: 4670 | Gene type: protein coding

About HNRNPM

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,444,975-8,489,114 (from NCBI)

This gene has 17 transcripts (splice variants), 231 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 50.0), colon (RPKM 44.6) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

HNRNPM Products(3)

mRNA Protein Name
NM_001297418.2 NP_001284347.1 heterogeneous nuclear ribonucleoprotein M isoform c
NM_005968.5 NP_005959.2 heterogeneous nuclear ribonucleoprotein M isoform a
NM_031203.4 NP_112480.2 heterogeneous nuclear ribonucleoprotein M isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17435768 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11984006 GOA
Biological Process GO Annotation Evidence Reference Source
involved in alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
19874820 GOA
Cellular Component GO Annotation Evidence Reference Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nuclear matrix IDA
IDA: Inferred from direct assay
19874820 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
19874820 GOA
located in paraspeckles IDA
IDA: Inferred from direct assay
19874820 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
9731529 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPM Protein Structure

HnRNP_M

HnRNP_M: Heterogeneous nuclear ribonucleoprotein M (41 - 70)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (74 - 143)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (206 - 274)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (655 - 722)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein M

CEA receptor

Recombinant HNRNPM Proteins

Cat. No. Product Name Accession Purity
HY-P72234 HNRNPM Protein, Human (His-SUMO) P52272-1 (A2-A730) ≥95%

Related Diseases

Diseases Alias
Contagious Pustular Dermatitis

Ecthyma, Contagious

Orf

Ecthyma Contagiosum

Scabby Mouth

Sheep Pox

Thistle Disease

Contagious Pustular Dermatosis
Bladder Clear Cell Adenocarcinoma

Bladder Mesonephric Adenocarcinoma

Clear Cell Adenocarcinoma Of Bladder
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06276 HNRNPM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HNRNPM RGD RGD:620369
Felis catus HNRNPM VGNC VGNC:67611
Mus musculus HNRNPM MGD MGI:1926465
Macaca mulatta HNRNPM VGNC VGNC:73498
Bos taurus HNRNPM VGNC VGNC:55212
Canis familiaris HNRNPM VGNC VGNC:41734
Others HNRNPM NCBI