1. Gene
  2. LMO2 - LIM domain only 2 Gene

LMO2 - LIM domain only 2 Gene

Homo sapiens

Also known as TTG2; LMO-2; RBTN2; RHOM2; RBTNL1

Gene ID: 4005 | Gene type: protein coding

About LMO2

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:33,858,576-33,892,076 (from NCBI)

This gene has 6 transcripts (splice variants), 193 orthologues, 20 paralogues and is associated with 51 phenotypes. Broad expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.4) and 24 other tissues.

Summary

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]

LMO2 Products(3)

mRNA Protein Name
NM_001142315.2 NP_001135787.1 rhombotin-2 isoform 2
NM_001142316.2 NP_001135788.1 rhombotin-2 isoform 2
NM_005574.4 NP_005565.2 rhombotin-2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16314316 GOA
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
16314316 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
16314316 GOA
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
16314316 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16314316 GOA
Cellular Component GO Annotation Evidence Reference Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
16314316 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMO2 Protein Structure

LIM

LIM: LIM domain (30 - 88)

LIM

LIM: LIM domain (94 - 150)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

rhombotin-2

LIM domain only protein 2

LMO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LMO2 P25791 MAPRE1 Homo sapiens Q15691 25416956
Intra
LMO2 P25791 MAPRE1 Homo sapiens Q15691 25416956
Intra
LMO2 P25791 KRT40 Homo sapiens Q6A162 25416956
Intra
LMO2 P25791 KRT40 Homo sapiens Q6A162 25416956
Intra
LMO2 P25791 KRTAP10-7 Homo sapiens P60409 25416956
Intra
LMO2 P25791 KRTAP10-7 Homo sapiens P60409 25416956
Intra
LMO2 P25791 KRTAP10-7 Homo sapiens P60409 25416956
Intra
LMO2 P25791 ADAMTSL4 Homo sapiens Q6UY14-3 25416956
Intra
LMO2 P25791 TFPT Homo sapiens P0C1Z6-2 25416956
Intra
LMO2 P25791 NUTM1 Homo sapiens Q86Y26 25416956
Intra
LMO2 P25791 MBIP Homo sapiens Q9NS73-5 25416956
Intra
LMO2 P25791 MAGEA8 Homo sapiens P43361 25416956
Intra
LMO2 P25791 MAGEA8 Homo sapiens P43361 25416956
Intra
LMO2 P25791 IFT43 Homo sapiens Q96FT9 25416956
Intra
LMO2 P25791 CLHC1 Homo sapiens Q8NHS4 25416956
Intra
LMO2 P25791 CLHC1 Homo sapiens Q8NHS4 25416956
Intra
LMO2 P25791 TRIM54 Homo sapiens Q9BYV2 25416956
Intra
LMO2 P25791 SSX2IP Homo sapiens Q9Y2D8 25416956
Intra
LMO2 P25791 SSX2IP Homo sapiens Q9Y2D8 25416956
Intra
LMO2 P25791 N4BP2L2 Homo sapiens Q92802 25416956
Intra
LMO2 P25791 N4BP2L2 Homo sapiens Q92802 25416956
Intra
LMO2 P25791 N4BP2L2 Homo sapiens Q92802 25416956
Intra
LMO2 P25791 BLZF1 Homo sapiens Q9H2G9 25416956
Intra
LMO2 P25791 BLZF1 Homo sapiens Q9H2G9 25416956
Intra
LMO2 P25791 CMTM5 Homo sapiens Q96DZ9 25416956
Intra
LMO2 P25791 TUFT1 Homo sapiens Q9NNX1 25416956
Intra
LMO2 P25791 TUFT1 Homo sapiens Q9NNX1 25416956
Intra
LMO2 P25791 TUFT1 Homo sapiens Q9NNX1 25416956
Intra
LMO2 P25791 REL Homo sapiens Q04864 25416956
Intra
LMO2 P25791 SKP1 Homo sapiens P63208 25416956
Intra
LMO2 P25791 SKP1 Homo sapiens P63208 25416956
Intra
LMO2 P25791 SKP1 Homo sapiens P63208 25416956
Intra
LMO2 P25791 SOX5 Homo sapiens P35711 25416956
Intra
LMO2 P25791 SOX5 Homo sapiens P35711 25416956
Intra
LMO2 P25791 HNRNPC Homo sapiens P07910 25416956
Intra
LMO2 P25791 HNRNPC Homo sapiens P07910 25416956
Intra
LMO2 P25791 PRKG1 Homo sapiens Q13976 31515488
Intra
LMO2 P25791 PRKG1 Homo sapiens Q13976 25416956
Intra
LMO2 P25791 PRKG1 Homo sapiens Q13976 25416956
Intra
LMO2 P25791 SAXO1 Homo sapiens Q8IYX7 31515488
Intra
LMO2 P25791 SAXO1 Homo sapiens Q8IYX7 25416956
Intra
LMO2 P25791 GRB2 Homo sapiens P62993 25416956
Intra
LMO2 P25791 GRB2 Homo sapiens P62993 25416956
Intra
LMO2 P25791 STAT3 Homo sapiens P40763 25416956
Intra
LMO2 P25791 GOLGA2 Homo sapiens Q08379 25416956
Intra
LMO2 P25791 GOLGA2 Homo sapiens Q08379 25416956
Intra
LMO2 P25791 LDB1 Homo sapiens Q86U70 33961781
Intra
LMO2 P25791 LDB1 Homo sapiens Q86U70 25416956
Intra
LMO2 P25791 LDB1 Homo sapiens Q86U70
Y2H
21988832
Intra
LMO2 P25791 ZNF24 Homo sapiens P17028 31515488
Intra
LMO2 P25791 ZNF24 Homo sapiens P17028 25416956
Intra
LMO2 P25791 ZFP64 Homo sapiens Q9NTW7 25416956
Intra
LMO2 P25791 ZFP64 Homo sapiens Q9NTW7 25416956
Intra
LMO2 P25791 DRAP1 Homo sapiens Q14919 25416956
Intra
LMO2 P25791 PHC2 Homo sapiens Q8IXK0 25416956
Intra
LMO2 P25791 PHC2 Homo sapiens Q8IXK0
Y2H
21516116
Intra
LMO2 P25791 TLE5 Homo sapiens Q08117 25416956
Intra
LMO2 P25791 TLE5 Homo sapiens Q08117 25416956
Intra
LMO2 P25791 MAPRE3 Homo sapiens Q9UPY8
Y2H
21516116
Intra
LMO2 P25791 MAPRE3 Homo sapiens Q9UPY8 16189514
Intra
LMO2 P25791 MAPRE3 Homo sapiens Q9UPY8 25416956
Intra
LMO2 P25791 RINT1 Homo sapiens Q6NUQ1 25416956
Intra
LMO2 P25791 RINT1 Homo sapiens Q6NUQ1 25416956
Intra
LMO2 P25791 RINT1 Homo sapiens Q6NUQ1 31515488
Intra
LMO2 P25791 RELA Homo sapiens Q04206 21988832
Intra
LMO2 P25791 RELA Homo sapiens Q04206 21988832
Intra
LMO2 P25791 KRT15 Homo sapiens P19012 25416956
Intra
LMO2 P25791 CALCOCO2 Homo sapiens Q13137 25416956
Intra
LMO2 P25791 MAPRE2 Homo sapiens Q15555 16189514
Intra
LMO2 P25791 MAPRE2 Homo sapiens Q15555 31515488
Intra
LMO2 P25791 MAPRE2 Homo sapiens Q15555 25416956
Intra
LMO2 P25791 MAPRE2 Homo sapiens Q15555 33961781
Intra
LMO2 P25791 MAPRE2 Homo sapiens Q15555 25416956
Intra
LMO2 P25791 TRIM23 Homo sapiens P36406 25416956
Intra
LMO2 P25791 NIF3L1 Homo sapiens Q9GZT8 25416956
Intra
LMO2 P25791 LZTS2 Homo sapiens Q9BRK4 25416956
Intra
LMO2 P25791 LZTS2 Homo sapiens Q9BRK4 25416956
Intra
LMO2 P25791 FHL3 Homo sapiens Q13643 25416956
Intra
LMO2 P25791 FHL3 Homo sapiens Q13643 25416956
Intra
LMO2 P25791 AGTRAP Homo sapiens Q6RW13 25416956
Intra
LMO2 P25791 CBY2 Homo sapiens Q8NA61 25416956
Intra
LMO2 P25791 CBY2 Homo sapiens Q8NA61 25416956
Intra
LMO2 P25791 MTUS2 Homo sapiens Q5JR59 25416956
Intra
LMO2 P25791 MTUS2 Homo sapiens Q5JR59 25416956
Intra
LMO2 P25791 ABI2 Homo sapiens Q9NYB9 29892012
Intra
LMO2 P25791 ABI2 Homo sapiens Q9NYB9 25416956
Intra
LMO2 P25791 GFAP Homo sapiens P14136 25416956
Intra
LMO2 P25791 GFAP Homo sapiens P14136 25416956
Intra
LMO2 P25791 BANP Homo sapiens Q8N9N5 25416956
Intra
LMO2 P25791 AIMP2 Homo sapiens Q13155 25416956
Intra
LMO2 P25791 AIMP2 Homo sapiens Q13155 25416956
Intra
LMO2 P25791 AIMP2 Homo sapiens Q13155 25416956
Intra
LMO2 P25791 HOOK1 Homo sapiens Q9UJC3 25416956
Intra
LMO2 P25791 HOOK1 Homo sapiens Q9UJC3 25416956
Intra
LMO2 P25791 MRFAP1L1 Homo sapiens Q96HT8 25416956
Intra
LMO2 P25791 IHO1 Homo sapiens Q8IYA8 25416956
Intra
LMO2 P25791 ROCK1 Homo sapiens Q13464 25416956
Intra
LMO2 P25791 ROCK1 Homo sapiens Q13464 25416956
Intra
LMO2 P25791 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
LMO2 P25791 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
LMO2 P25791 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
LMO2 P25791 C1orf94 Homo sapiens Q6P1W5 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

LMO2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81528 LMO2 Antibody (YA1273) IHC-P Human

Related Diseases

Diseases Alias
Severe Combined Immunodeficiency, X-Linked

X-Linked Severe Combined Immunodeficiency

SCIDX1

XSCID

Scidx

X-Linked Scid

X-Scid

Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative

Scid, X-Linked

Immunodeficiency 4

Imd4

Gamma Chain Deficiency

Scid-X1

X-Linked Combined Immunodeficiency Diseases

Thymic Epithelial Hypoplasia

Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency

Severe Combined Immunodeficiency T- B+, X-Linked

Il2rg Scid, T- B+ Nk-

T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency

T-B+ Scid Due To Gamma Chain Deficiency

T-B+ Severe Combined Immunodeficiency, X-Linked

Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative

Agammaglobulinemia Swiss Type

Scid X-Linked

Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative

Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative

Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic

Lymphoma Lymphoblastic

Precursor Cell Lymphoblastic Lymphoma

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos

Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Granulomatous Disease, Chronic, X-Linked

CGDX

Chronic Granulomatous Disease, X-Linked

X-Linked Chronic Granulomatous Disease

Cgd

Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked

Cdgx

X-Linked Chronic Cytochrome B-Negative Granulomatous Disease

Chronic Granulomatous Disease Cytochrome B-Negative X-Linked

Chronic Granulomatous Disease Cytochrome B-Positive X-Linked

Granulomatous Disease, Chronic, X-Linked, Variant

Adenosine Deaminase Deficiency

Ada Deficiency

Ada-Scid

Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Adenosine Deaminase Deficient Severe Combined Immunodeficiency

Scid Due To Ada Deficiency

Severe Combined Immunodeficiency Due To Ada Deficiency

Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency

Ada

Scid Due To Adenosine Deaminase Deficiency

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Childhood T-Cell Acute Lymphoblastic Leukemia

T-Cell Childhood Acute Lymphoblastic Leukemia

Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia

T-Cell Childhood Acute Lymphocytic Leukemia

Childhood T Lymphoblastic Leukemia/Lymphoma

Ureteral Lymphoma

Lymphoma Of Ureter

Ureter Lymphoma

Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma

High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

Hgbl-Dh/Th

High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements

High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement

Purine-Pyrimidine Metabolic Disorder

Inborn Errors Of Purine-Pyrimidine Metabolism

Disorder Of Purine Or Pyrimidine Metabolism

Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Metachromatic Leukodystrophy

Arylsulfatase A Deficiency

MLD

Arsa Deficiency

Sulfatide Lipidosis

Metachromatic Leukoencephalopathy

Cerebral Sclerosis, Diffuse, Metachromatic Form

Cerebroside Sulfatase Deficiency

Leukodystrophy, Metachromatic

Pseudoarylsulfatase A Deficiency

Leukodystrophy Metachromatic

Sulfatidosis

Metachromatic Leukodystrophy, Late Infantile

Metachromatic Leukodystrophy Variant

Deficiency Of Cerebroside-Sulfatase

Scholz Cerebral Sclerosis

Sulfatide Lipoidosis

Cerebral Sclerosis Diffuse Metachromatic Form

Arylsulfatase A Deficiency Disease

Cerebroside Sulphatase Deficiency Disease

Greenfield Disease

Metachromatic Leukodystrophy, Adult

Metachromatic Leukodystrophy, Juvenile

Leukodystrophy Metachromatic Adult

Leukodystrophy Metachromatic Juvenile

Leukodystrophy Metachromatic Late Infantile

Metachromatic Leukodystrophy, Adult Type

Metachromatic Leukodystrophy, Juvenile Type

Metachromatic Leukodystrophy, Infant

Greenfield'S Disease

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LMO2 RGD RGD:1307101
Mus musculus LMO2 MGD MGI:102811
Felis catus LMO2 VGNC VGNC:82023
Bos taurus LMO2 VGNC VGNC:30934
Macaca mulatta LMO2 VGNC VGNC:74431