OGT - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

Homo sapiens

Also known as OGT1; HRNT1; MRX106; XLID106; HINCUT-1; O-GLCNAC

Gene ID: 8473 | Gene type: protein coding

About OGT

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,533,104-71,575,892 (from NCBI)

This gene has 21 transcripts (splice variants), 263 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 56.6), spleen (RPKM 53.1) and 25 other tissues.

Summary

This gene encodes a Glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

OGT Products(2)

mRNA	Protein	Name
NM_181672.3	NP_858058.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1
NM_181673.3	NP_858059.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	18288188	GOA
enables protein O-acetylglucosaminyltransferase activity	EXP EXP: Inferred from Experiment	30770249	GOA
enables protein O-acetylglucosaminyltransferase activity	IDA IDA: Inferred from direct assay	21285374	GOA
enables protein O-acetylglucosaminyltransferase activity	IMP IMP: Inferred from mutant phenotype	23777819	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12150998	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	20824293	GOA
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	37541260	GOA
involved in negative regulation of non-canonical inflammasome complex assembly	IDA IDA: Inferred from direct assay	37962578	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	26678539	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	26678539	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	37541260	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	21285374	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23222540	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23352454	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	34074792	GOA
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	21240259	GOA
involved in protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	23353889	GOA
involved in protein processing	IMP IMP: Inferred from mutant phenotype	28584052	GOA
involved in regulation of Rac protein signal transduction	IDA IDA: Inferred from direct assay	18288188	GOA
involved in regulation of glycolytic process	IDA IDA: Inferred from direct assay	22923583	GOA
involved in regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	18288188	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26678539	GOA
involved in response to insulin	IDA IDA: Inferred from direct assay	18288188	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NSL complex	IDA IDA: Inferred from direct assay	20018852	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21285374	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	20018852	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21285374	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18288188	GOA
part of protein N-acetylglucosaminyltransferase complex	IDA IDA: Inferred from direct assay	21240259	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	26678539	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OGT Protein Structure

TPR_11

TPR_1

TPR_11

Glyco_transf_41

0
200
400
600
800
1046 a.a.

Protein Preferred Names

Protein Names

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

O-GlcNAc transferase p110 subunit

OGT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OGT	O15294	TET2	Homo sapiens	E7EQS8	Y2H Prey Pooling	25416956
Intra	OGT	O15294	TET2	Homo sapiens	E7EQS8	Validated Y2H	25416956
Intra	OGT	O15294	TRAK1	Homo sapiens	Q9UPV9	TAP	27705803
Intra	OGT	O15294	PHC3	Homo sapiens	Q8NDX5	Y2H Prey Pooling	25416956
Intra	OGT	O15294	PHC3	Homo sapiens	Q8NDX5	Y2H Array	25416956
Intra	OGT	O15294	TET2	Homo sapiens	Q6N021-1	Pull Down	23222540
Intra	OGT	O15294	TET3	Homo sapiens	O43151	Pull Down	23353889
Intra	OGT	O15294	TET3	Homo sapiens	O43151	Pull Down	23222540
Intra	OGT	O15294	TET2	Homo sapiens	Q6N021	Anti Bait CoIP	23353889
Intra	OGT	O15294	TET2	Homo sapiens	Q6N021	Pull Down	23353889
Intra	OGT	O15294	PPP1CC	Homo sapiens	P36873	Anti Bait CoIP	27505673
Intra	OGT	O15294	URI1	Homo sapiens	O94763	Anti Bait CoIP	27505673
Intra	OGT	O15294	URI1	Homo sapiens	O94763	Pull Down	27505673
Intra	OGT	O15294	URI1	Homo sapiens	O94763	Enzymatic Study	27505673
Intra	OGT	O15294	URI1	Homo sapiens	O94763	Anti Tag CoIP	27505673
Intra	OGT	O15294	TAB1	Homo sapiens	Q15750	Enzymatic Study	27505673
Cross	OGT	O15294	Hoxa1	Mus musculus	P09022	BiFC	23088713
Cross	OGT	O15294	Hoxa1	Mus musculus	P09022	Y2H	23088713
Intra	OGT	O15294	HCFC1	Homo sapiens	P51610	TAP	27705803
Intra	OGT	O15294	HCFC1	Homo sapiens	P51610	Protease Assay	21295698
Intra	OGT	O15294	SNAP29	Homo sapiens	O95721	Pull Down	25419848
Intra	OGT	O15294	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	25419848
Intra	OGT	O15294	NFATC1	Homo sapiens	O95644	Anti Bait CoIP	17882263
Intra	OGT	O15294	PSG1	Homo sapiens	P11464	Y2H Prey Pooling	25416956
Intra	OGT	O15294	PSG1	Homo sapiens	P11464	Validated Y2H	25416956
Intra	OGT	O15294	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17882263
Intra	OGT	O15294	NUP62CL	Homo sapiens	Q9H1M0	Y2H Prey Pooling	25416956
Intra	OGT	O15294	NUP62CL	Homo sapiens	Q9H1M0	Y2H Pooling	16189514
Cross	OGT	O15294	Tet3	Mus musculus	Q8BG87	Pull Down	23353889
Cross	OGT	O15294	Tet3	Mus musculus	Q8BG87	Anti Tag CoIP	23353889
Cross	OGT	O15294	Ppp1cc	Rattus norvegicus	P63088	Pull Down	27505673

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked 106

XLID106	Mrx106
Mental Retardation, X-Linked 106	Mental Retardation, X-Linked, Type 106

Myoepithelioma

Benign Myoepithelioma	Myoepithelial Adenoma
Myoepithelial Neoplasm	Malignant Myoepithelioma

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Adams-Oliver Syndrome

Adams Oliver Syndrome	Aos
Congenital Scalp Defects With Distal Limb Reduction Anomalies	Aplasia Cutis Congenita With Terminal Transverse Limb Defects
Congenital Scalp Defects With Distal Limb Anomalies	Limb, Scalp And Skull Defects
Limb Scalp And Skull Defects	Absence Defect Of Limbs, Scalp, And Skull

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119738	OSMI-1	Inhibitor	99.90%	Unkown
HY-114361	OSMI-4	Inhibitor	99.55%	Unkown
HY-112174	UDP-GlcNAc disodium		≥99.0%	Unkown
HY-136282	OGT-IN-2	Inhibitor	99.82%	Unkown
HY-145934A	UDP-GlcNAz disodium		98.93%	Unkown
HY-139793	UDP-glucosamine disodium		99.43%	Unkown
HY-135784	OSMI-2	Inhibitor	98.73%	Unkown
HY-148113	PG 34		≥98.0%	Unkown
HY-119738A	(Rac)-OSMI-1	Inhibitor	96.51%	Unkown
HY-101548	OGT-IN-1	Inhibitor	98.14%	Unkown
HY-125278	OGT-IN-4	Inhibitor	/	Unkown
HY-135785	OSMI-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OGT	MGD	MGI:1339639
Rattus norvegicus	OGT	RGD	RGD:62060
Others	OGT	NCBI

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