2. Anti-infection NF-κB Cell Cycle/DNA Damage PI3K/Akt/mTOR Autophagy Apoptosis
  3. Bacterial Antibiotic NF-κB PERK Akt Autophagy Apoptosis
  4. Bavachalcone

Bavachalcone  (Synonyms: Broussochalcone B)

Cat. No.: HY-N0231 Purity: 99.95%
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Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.

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Bavachalcone Chemical Structure

Bavachalcone Chemical Structure

CAS No. : 28448-85-3

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5 mg USD 129 In-stock
10 mg USD 188 In-stock
25 mg USD 340 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Bavachalcone:

Bavachalcone Related Antibodies

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Description

Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro[1][2][3][4].

In Vitro

Bavachalcone (5μg/mL; 1-48 h) inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1[1].
. Bavachalcone (0-100 μg/mL; 24h) is toxic to HepG2 cells with IC50 of 20 μg/mL[3]. Bavachalcone (20 μg/mL; 24 h) induces apoptosis in HepG2[3].
Bavachalcone (0-20μg/mL; 24 h) induces cell cycle arrest in HepG2 cells[3].
Bavachalcone (0-20μg/mL; 24 h) induces autophagy through Akt-mTOR signaling pathway[3].
Bavachalcone (5-10 μM; 2 h) inhibits the activation of NF-κB pathway in LPS (HY-D1056)-induced BV2 cells, upregulated the expression of A20 and TAX1BP1, and enhanced their interaction[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bavachalcone Related Antibodies

Western Blot Analysis[1]

Cell Line: RANKL treated bone marrow-derived macrophages
Concentration: 5 μg/mL
Incubation Time: 1 h
Result: Reduced the phosphorylation levels of ERK and Akt.

Western Blot Analysis[1]

Cell Line: RANKL treated bone marrow-derived macrophages
Concentration: 5 μg/mL
Incubation Time: 0, 12, 24 and 48 h
Result: Reduced the levels of c-Fos and NFATc1.

Western Blot Analysis[3]

Cell Line: HepG2 cell
Concentration: 20 μg/mL
Incubation Time: 24 h
Result: Significantly increased the levels of caspase-3.

Western Blot Analysis[3]

Cell Line: HepG2 cell
Concentration: 0, 5, 10 and 20 μg/mL
Incubation Time: 24 h
Result: Decreased the levels of early cell cycle regulatory proteins cdk4 and cdk2.
Increased the levels of p21 and p27.

Western Blot Analysis[3]

Cell Line: HepG2 cell
Concentration: 0, 5, 10 and 20 μg/mL
Incubation Time: 24 h
Result: Inhibited the phosphorylation and expression of both Akt and mTOR.

Western Blot Analysis[4]

Cell Line: LPS (HY-D1056) treated BV2 cells
Concentration: 5 μM and 10 μM
Incubation Time: 2 h
Result: Significantly decreased the expression of TRAF6 and phosphorylation of P65 and IκBα.
Increased the expression of A20 and TAX1BP1
In Vivo

Bavachalcone (30-60 mg/kg; Intraperitoneal injection; 4 days) exerts anti-neuroinflammatory and anti-depressive effects in LPS (HY-D1056) -induced mouse models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (HY-D1056) treated male C57BL/6 mice (8 weeks, 20 ± 2 g)
Dosage: 30 mg/kg and 60 mg/kg
Administration: Intraperitoneal injection (i.p.); 4 days
Result: Attenuated LPS-induced depression-like behaviors in mice.
Inhibited LPS-induced activation of microglia in the brain of mice.
Inhibited LPS-induced NF-κB pathway activation and upregulated the expression of A20 and TAX1BP1 in the cortex of mice.
Weakened the production of TNF-α and IL-6 in the cortex of mice.
Molecular Weight

324.37

Formula

C20H20O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(C1=CC(C/C=C(C)\C)=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (104.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0829 mL 15.4145 mL 30.8290 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

COA (244 KB) HNMR (173 KB) RP-HPLC (332 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0829 mL 15.4145 mL 30.8290 mL 77.0725 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL 15.4145 mL
10 mM 0.3083 mL 1.5414 mL 3.0829 mL 7.7072 mL
15 mM 0.2055 mL 1.0276 mL 2.0553 mL 5.1382 mL
20 mM 0.1541 mL 0.7707 mL 1.5414 mL 3.8536 mL
25 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0829 mL
30 mM 0.1028 mL 0.5138 mL 1.0276 mL 2.5691 mL
40 mM 0.0771 mL 0.3854 mL 0.7707 mL 1.9268 mL
50 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5414 mL
60 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2845 mL
80 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9634 mL
100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.7707 mL
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Bavachalcone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bavachalcone28448-85-3Broussochalcone BBacterialAntibioticNF-κBPERKAktAutophagyApoptosisNuclear factor-κBNuclear factor-kappaBProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasePKBProtein kinase BHepG2 cellsOsteoclastogenesis Anticancer agentAnti-depressionInhibitorinhibitorinhibit

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