2. Gene
  3. AQP10 - aquaporin 10 Gene

AQP10 - aquaporin 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AQPA_HUMAN

Gene ID: 89872 | Gene type: protein coding

About AQP10

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,321,093-154,325,325 (from NCBI)

This gene has 3 transcripts (splice variants), 390 orthologues and 11 paralogues. Biased expression in duodenum (RPKM 31.0) and small intestine (RPKM 22.0).

Summary

This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]

AQP10 Products(1)

mRNA Protein Name
NM_080429.3 NP_536354.2 aquaporin-10
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables glycerol channel activity IDA
IDA: Inferred from direct assay
30420639 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables water channel activity IDA
IDA: Inferred from direct assay
30420639 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to acidic pH IDA
IDA: Inferred from direct assay
30420639 GOA
involved in glycerol transmembrane transport IDA
IDA: Inferred from direct assay
30420639 GOA
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
30420639 GOA
involved in response to toxic substance IDA
IDA: Inferred from direct assay
17575980 GOA
involved in water transport IDA
IDA: Inferred from direct assay
30420639 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
30420639 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP10 Protein Structure

MIP

MIP: Major intrinsic protein (20 - 260)

  • 0
  • 100
  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

aquaporin-10

AQP-10

AQP10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AQP10 Q96PS8 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra
AQP10 Q96PS8 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra
AQP10 Q96PS8 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
AQP10 Q96PS8 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
AQP10 Q96PS8 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
AQP10 Q96PS8 PLP1 Homo sapiens P60201-2
Y2H Array
32296183
Intra
AQP10 Q96PS8 PLP1 Homo sapiens P60201-2
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
AQP10 Q96PS8 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
AQP10 Q96PS8 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
AQP10 Q96PS8 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
AQP10 Q96PS8 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra
AQP10 Q96PS8 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
AQP10 Q96PS8 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
Intra
AQP10 Q96PS8 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
Intra
AQP10 Q96PS8 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
AQP10 Q96PS8 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
AQP10 Q96PS8 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
AQP10 Q96PS8 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
AQP10 Q96PS8 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
AQP10 Q96PS8 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
AQP10 Q96PS8 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
AQP10 Q96PS8 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Intra
AQP10 Q96PS8 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
AQP10 Q96PS8 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pompholyx

Dyshidrosis

Vesicular Eczema Of Hands And/Or Feet

Cheiropompholyx

Dyshydrotic Eczema

Eczema, Dyshidrotic

Vesicular Hand Eczema
Viral Gastritis
Fox-Fordyce Disease

Fox Fordyce Disease

Apocrine Miliaria

Fox-Fordyce Syndrome

Miliaria, Apocrine
Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus

Diabetes Insipidus, Nephrogenic

Diabetes Insipidus Nephrogenic

Congenital Nephrogenic Diabetes Insipidus

Adh Resistant Diabetes Insipidus

Diabetes Insipidus Nephrogenic X-Linked

Diabetes Insipidus Nephrogenic Type 1

Adh-Resistant Diabetes Insipidus

Diabetes Insipidus Renalis

Ndi

Renal Diabetes Insipidus

Familial Nephrogenic Diabetes

Antidiuretic-Hormone-Resistant Diabetes Insipidus

Adiuretin-Resistant Diabetes Insipidus

Ndi - [Nephrogenic Diabetes Insipidus]

Diabetes Tenuifluus

Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus

Hereditary Nephrogenic Diabetes Insipidus

Familial Nephrogenic Diabetes Insipidus

Primary Nephrogenic Diabetes Insipidus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00872 AQP10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus AQP10 VGNC VGNC:26044
Macaca mulatta AQP10 VGNC VGNC:69841
Rattus norvegicus AQP10 RGD RGD:1596307
Felis catus AQP10 VGNC VGNC:59859