2. Gene
  3. Aak1 - AP2 associated kinase 1 Gene

Aak1 - AP2 associated kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1563580

Gene ID: 500244 | Gene type: protein coding

About Aak1

Primary_assembly 4: 119,295,257-119,450,969 forward strand.mRatBN7.2:CM026977.1

This gene has 8 transcripts (splice variants), 268 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in Brain (RPKM 315.7), Adrenal (RPKM 93.7) and 9 other tissues.

Summary

Enables AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in protein autophosphorylation and regulation of clathrin-dependent endocytosis. Located in cell leading edge and terminal bouton. Part of clathrin complex. Is active in presynapse. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Aak1 Products(1)

mRNA Protein Name
NM_001173450.1 NP_001166921.1 AP2-associated protein kinase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables AP-2 adaptor complex binding IDA
IDA: Inferred from direct assay
11877461 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11877461 RGD
Biological Process GO Annotation Evidence Reference Source
involved in presynaptic endocytosis EXP
EXP: Inferred from Experiment
33376223 RGD
involved in presynaptic endocytosis IDA
IDA: Inferred from direct assay
33376223 RGD
involved in regulation of clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
11877461 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in calyx of Held EXP
EXP: Inferred from Experiment
33376223 RGD
is active in calyx of Held IDA
IDA: Inferred from direct assay
33376223 RGD
located in cell leading edge IDA
IDA: Inferred from direct assay
11877461 RGD
part of clathrin complex IDA
IDA: Inferred from direct assay
11877461 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
11877461 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
11877461 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aak1 Protein Structure

STKc_NAK_like

STKc_NAK_like: cd14037 (41 - 315)

Herpes_BLLF1

Herpes_BLLF1: cl37540 (319 - 422)

BMP2K_C

BMP2K_C: cl21131 (1089 - 1300)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1306 a.a.
Protein Preferred Names Protein Names

AP2-associated protein kinase 1

adaptor-associated kinase 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-134829 BMS-986176 98.79% Phase 2
Pre-clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117626 LP-935509 Inhibitor 99.74% Unkown
HY-123940 SGC-AAK1-1 98.93% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-120179 LP-922761 98.21% Unkown
HY-148063 DB0614 98.80% Unkown
HY-115868 BMS-911172 99.49% Unkown
HY-101290A BMT-090605 hydrochloride Inhibitor 98.76% Unkown
HY-135871A BMT-124110 formic Inhibitor / Unkown
HY-120179A LP-922761 hydrate ≥98.0% Unkown
HY-135871 BMT-124110 98.93% Unkown
HY-117453 BMS-901715 / Unkown
HY-161261 SARS-CoV-2-IN-81 Inhibitor / Unkown
HY-101290 BMT-090605 Inhibitor / Unkown
HY-149054 GSK-3β inhibitor 13 Inhibitor / Unkown
HY-144302A AAK1-IN-3 TFA / Unkown
HY-147083 SGC-AAK1-1N Inhibitor / Unkown
HY-144302 AAK1-IN-3 / Unkown
HY-145839 AAK1-IN-5 / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-145838 AAK1-IN-4 / Unkown
HY-144301 AAK1-IN-2 / Unkown
HY-144301A AAK1-IN-2 TFA / Unkown
HY-162388 TIM-098a Inhibitor / Unkown
HY-120092 BMT-046091 Inhibitor / Unkown
HY-159879 AAK1-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aak1 NCBI NCBI:22848