CD207 - CD207 molecule Gene

Homo sapiens

Also known as CLEC4K

Gene ID: 50489 | Gene type: protein coding

About CD207

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,824,130-70,835,816 (from NCBI)

This gene has 1 transcript (splice variant), 877 orthologues, 14 paralogues and is associated with 1 phenotype. Biased expression in skin (RPKM 26.1), esophagus (RPKM 6.2) and 1 other tissue.

Summary

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

CD207 Products(1)

mRNA	Protein	Name
NM_015717.5	NP_056532.4	C-type lectin domain family 4 member K

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables carbohydrate binding	IDA IDA: Inferred from direct assay	20026605	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	17334373	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD207 Protein Structure

Lectin_C

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 4 member K

C-type lectin domain family 4, member K

Recombinant CD207 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7819	Langerin/CD207 Protein, Human (HEK293, His)	AAH22278.1 (Y64-P328)	≥95%

Related Diseases

Diseases

Alias

Birbeck Granule Deficiency

Birbeck Granules, Absence Of	BIRGD
Absence Of Birbeck Granules

Langerhans Cell Sarcoma

Malignant Langerhans Cell Sarcoma

Histiocytosis

Chronic Histiocytosis X	Hand Schuller Christian Disease
Hand-Schüller-Christian Disease	Histiocytic Syndrome
Histiocytosis, Langerhans-Cell

Langerhans Cell Histiocytosis

Histiocytosis X	Lch
Langerhans Cell Granulomatosis	Langerhans-Cell Histiocytosis
Letterer-Siwe Disease	Hashimoto-Pritzger Disease
Histiocytosis, Langerhans-Cell	Langerhan'S Cell Histiocytosis
Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes	Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes
Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes	Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb
Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck
Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb	Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Involving Spleen	Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes
Letterer-Siwe Disease Of Intrapelvic Lymph Nodes	Letterer-Siwe Disease Of Intrathoracic Lymph Nodes
Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb	Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb
Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Of Spleen	Familial Letterer-Siwe Disease
Langerhans-Cell Histiocytosis Nos

Follicular Dendritic Cell Sarcoma

Dendritic Cell Sarcoma	Dendritic Cell Sarcoma, Follicular
Follicular Dendritic Cell Tumour	Dendritic Cell Sarcoma, Interdigitating
Dendritic Cell Sarcoma, Not Otherwise Specified

Non-Langerhans-Cell Histiocytosis

Histiocytosis, Non-Langerhans-Cell

Non-Langerhans Cell Histiocytosis

Reticulohistiocytic Granuloma

Reticulohistiocytoma	Solitary Reticulohistiocytoma
Solitary Histiocytoma	Solitary Reticulohistiocytosis

Histiocytic And Dendritic Cell Cancer

Histiocytic And Dendritic Cell

Juvenile Xanthogranuloma

Multiple Eruptive Juvenile Xanthogranuloma	Naevoxanthoendothelioma
Xanthoma Neviforme	Xanthogranuloma, Juvenile

Vulvar Proximal-Type Epithelioid Sarcoma

Central Epithelioid Sarcoma

Proximal-Type Epithelioid Sarcoma

Adult Xanthogranuloma

Interdigitating Dendritic Cell Sarcoma

Interdigitating Cell Sarcoma	Dendritic Cell Sarcoma, Interdigitating
Reticulum Cell Sarcoma

Frontal Sinus Benign Neoplasm

Neoplasm Of Frontal Sinus

Tumor Of The Frontal Sinus

Seborrheic Dermatitis

Seborrhoeic Dermatitis	Seborrhea
Seborrhoeic Eczema	Skin Seborrheic
Dermatitis, Seborrheic

Beach Ear

Acute Swimmer'S Ear	Acute Bacterial Inflammation Of External Ear
Acute Otitis Externa, Diffuse	Acute Swimmers' Ear
Tank Ear

Rhinoscleroma

Fibrosarcoma Of Bone

Malignant Histiocytosis	Malignant Fibroxanthoma
Malignant Fibrous Histiocytoma	Histiocytic Medullary Reticulosis
Nasal Type Extranodal Nk/T-Cell Lymphoma	Histiocytic Sarcoma

Cavernous Sinus Meningioma

Meningioma Of The Cavernous Sinus

Otorrhea

Discharging Ear

Malignant Histiocytic Disease

Histiocytic Disorders, Malignant

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02208	CD207 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD207	VGNC	VGNC:27011
Rattus norvegicus	CD207	RGD	RGD:1565913
Felis catus	CD207	VGNC	VGNC:60596
Mus musculus	CD207	MGD	MGI:2180021
Canis familiaris	CD207	VGNC	VGNC:54285
Macaca mulatta	CD207	VGNC	VGNC:70818
Others	CD207	NCBI

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