ZCCHC12 - zinc finger CCHC-type containing 12 Gene

Homo sapiens

Also known as SIZN; SIZN1; PNMA7A

Gene ID: 170261 | Gene type: protein coding

About ZCCHC12

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,823,824-118,826,968 (from NCBI)

This gene has 1 transcript (splice variant), 591 orthologues and 13 paralogues. Biased expression in endometrium (RPKM 50.3), brain (RPKM 9.1) and 1 other tissue.

Summary

This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

ZCCHC12 Products(2)

mRNA	Protein	Name
NM_001312891.2	NP_001299820.1	zinc finger CCHC domain-containing protein 12
NM_173798.4	NP_776159.1	zinc finger CCHC domain-containing protein 12

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZCCHC12 Protein Structure

PNMA

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

zinc finger CCHC domain-containing protein 12

paraneoplastic Ma antigen family member 7A

ZCCHC12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZCCHC12	Q6PEW1	MAGEA11	Homo sapiens	P43364-2	Y2H Array	25416956
Intra	ZCCHC12	Q6PEW1	MAGEA11	Homo sapiens	P43364-2	Y2H Prey Pooling	25416956
Intra	ZCCHC12	Q6PEW1	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	ZCCHC12	Q6PEW1	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	ZCCHC12	Q6PEW1	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	ZCCHC12	Q6PEW1	MAGEA11	Homo sapiens	G5E962	Validated Y2H	25910212
Intra	ZCCHC12	Q6PEW1	MAGEA11	Homo sapiens	G5E962	Y2H Bait-Prey Pool	25910212
Intra	ZCCHC12	Q6PEW1	MAGEA11	Homo sapiens	G5E962	Y2H Array	25910212
Intra	ZCCHC12	Q6PEW1	PGK2	Homo sapiens	P07205	Anti Tag CoIP	28514442
Intra	ZCCHC12	Q6PEW1	PGK2	Homo sapiens	P07205	Anti Tag CoIP	33961781
Intra	ZCCHC12	Q6PEW1	ABHD5	Homo sapiens	Q8WTS1	Validated Y2H	32296183
Intra	ZCCHC12	Q6PEW1	ABHD5	Homo sapiens	Q8WTS1	Y2H Array	32296183
Intra	ZCCHC12	Q6PEW1	ABHD5	Homo sapiens	Q8WTS1	Y2H Prey Pooling	32296183
Intra	ZCCHC12	Q6PEW1	CD207	Homo sapiens	Q9UJ71	Validated Y2H	32296183
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25910212
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25910212
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Y2H Bait-Prey Pool	25910212
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	32296183
Intra	ZCCHC12	Q6PEW1	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	ZCCHC12	Q6PEW1	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	ZCCHC12	Q6PEW1	KPNA3	Homo sapiens	O00505	Y2H Array	32296183
Intra	ZCCHC12	Q6PEW1	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	32296183
Intra	ZCCHC12	Q6PEW1	TFCP2	Homo sapiens	Q12800	Validated Y2H	25910212
Intra	ZCCHC12	Q6PEW1	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	ZCCHC12	Q6PEW1	TFCP2	Homo sapiens	Q12800	Y2H Array	25910212
Intra	ZCCHC12	Q6PEW1	TFCP2	Homo sapiens	Q12800	Y2H Bait-Prey Pool	25910212
Intra	ZCCHC12	Q6PEW1	TMEM43	Homo sapiens	Q9BTV4	Validated Y2H	32296183
Intra	ZCCHC12	Q6PEW1	TADA2A	Homo sapiens	O75478	Y2H Prey Pooling	32296183
Intra	ZCCHC12	Q6PEW1	TADA2A	Homo sapiens	O75478	Y2H Array	32296183
Intra	ZCCHC12	Q6PEW1	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	ZCCHC12	Q6PEW1	SUMO1	Homo sapiens	P63165	Validated Y2H	25910212
Intra	ZCCHC12	Q6PEW1	SUMO1	Homo sapiens	P63165	Y2H Bait-Prey Pool	25910212
Intra	ZCCHC12	Q6PEW1	SUMO1	Homo sapiens	P63165	Validated Y2H	25416956
Intra	ZCCHC12	Q6PEW1	SUMO1	Homo sapiens	P63165	Y2H Array	25416956
Intra	ZCCHC12	Q6PEW1	SUMO1	Homo sapiens	P63165	Y2H Array	25910212
Intra	ZCCHC12	Q6PEW1	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	ZCCHC12	Q6PEW1	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Potocki-Lupski Syndrome

PTLS	Chromosome 17p11.2 Duplication Syndrome
17p11.2 Microduplication Syndrome	Duplication 17p11.2 Syndrome
Trisomy 17p11.2	Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))
17p11.2 Duplication Syndrome	Dup(17)(P11.2p11.2)
Pls	Chromosome 17, Trisomy 17p11 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16000	ZCCHC12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZCCHC12	VGNC	VGNC:79660
Mus musculus	ZCCHC12	MGD	MGI:1919943
Rattus norvegicus	ZCCHC12	RGD	RGD:1359439
Bos taurus	ZCCHC12	VGNC	VGNC:50125

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