PRDX1 - peroxiredoxin 1 Gene

Homo sapiens

Also known as PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A

Gene ID: 5052 | Gene type: protein coding

About PRDX1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,511,051-45,522,890 (from NCBI)

This gene has 6 transcripts (splice variants), 246 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 269.3), kidney (RPKM 192.7) and 24 other tissues.

Summary

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the Antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in Cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

PRDX1 Products(4)

mRNA	Protein	Name
NM_001202431.2	NP_001189360.1	peroxiredoxin-1
NM_002574.4	NP_002565.1	peroxiredoxin-1
NM_181696.3	NP_859047.1	peroxiredoxin-1
NM_181697.3	NP_859048.1	peroxiredoxin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peroxidase activity	IDA IDA: Inferred from direct assay	11986303	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15105503	GOA
enables thioredoxin peroxidase activity	IDA IDA: Inferred from direct assay	18606987	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within hydrogen peroxide catabolic process	IDA IDA: Inferred from direct assay	11986303	GOA
involved in hydrogen peroxide catabolic process	IDA IDA: Inferred from direct assay	18606987	GOA
involved in natural killer cell activation	IDA IDA: Inferred from direct assay	8462106	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17603937	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17603937	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX1 Protein Structure

AhpC-TSA

1-cysPrx_C

0
100
199 a.a.

Protein Preferred Names

Protein Names

peroxiredoxin-1

epididymis secretory sperm binding protein

PRDX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRDX1	Q06830	DPP9	Homo sapiens	Q86TI2-2	Validated Y2H	32814053
Intra	PRDX1	Q06830	DPP9	Homo sapiens	Q86TI2-2	Y2H Pooling	32814053
Intra	PRDX1	Q06830	DPP9	Homo sapiens	Q86TI2-2	Y2H Array	32814053
Intra	PRDX1	Q06830	PRDX4	Homo sapiens	Q13162	Y2H	21988832
Intra	PRDX1	Q06830	STK4	Homo sapiens	Q13043	Anti Tag CoIP	23386615
Intra	PRDX1	Q06830	STK4	Homo sapiens	Q13043	Y2H	23386615
Intra	PRDX1	Q06830	STK4	Homo sapiens	Q13043	Pull Down	23386615
Intra	PRDX1	Q06830	STK4	Homo sapiens	Q13043	Protein Kinase Assay	23386615
Intra	PRDX1	Q06830	AR	Homo sapiens	P10275	Anti Bait CoIP	17909037
Intra	PRDX1	Q06830	PTEN	Homo sapiens	P60484	Anti Bait CoIP	19369943
Intra	PRDX1	Q06830	PTEN	Homo sapiens	P60484	Anti Tag CoIP	19369943
Intra	PRDX1	Q06830	PTEN	Homo sapiens	P60484	Pull Down	19369943
Intra	PRDX1	Q06830	TERF1	Homo sapiens	P54274	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71231	PRDX1 Protein, Human (His)	Q06830 (M1-K199)	≥95%

PRDX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80782	Peroxiredoxin 1 Antibody (YA692)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Methylmalonic Aciduria And Homocystinuria, Cblc Type

MAHCC	Vitamin B12 Metabolic Defect With Combined Deficiency Of Methylmalonyl-Coa Mutase And Homocysteine:Methyltetrahydrofolate Methyltransferase
Methylmalonic Aciduria And Homocystinuria, Cblc Type, Digenic	Methylmalonic Aciduria And Homocystinuria Type Cblc
Cobalamin C Disease	Methylmalonic Acidemia With Homocystinuria Cblc
Methylmalonic Acidemia And Homocystinuria, Cblc Type	Methylmalonic Aciduria And Homocystinuria, Vitamin B12-Responsive
Cobalamin C Deficiency	Methylmalonic Acidemia With Homocystinuria, Type Cblc
Cblc Defect	Cobalamin C Defect
Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblc	Methylmalonic Aciduria With Homocystinuria, Type Cblc
Methylmalonic Acidemia And Homocystinuria Cblc Type	Methylmalonic Aciduria And Homocystinuria Vitamin B12-Responsive
Aciduria, Methylmalonic, And Homocystinuria, Cblc Type	Methylmalonic Acidemia With Homocystinuria

Anthrax Disease

Anthrax	Ragpicker'S Disease
Black Baine	Malignant Edema
Malignant Pustule	Siberian Plague
Wool Sorter'S Disease	Gas Gangrene
Cutaneous Anthrax	Anthrax Infection
Splenic Fever

Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax

Inhalation Anthrax

Pulmonary Anthrax	Respiratory Anthrax
Inhalational Anthrax	Wool-Sorters' Disease
Woolsorters' Disease	Inhalation Anthrax Disease
Respiratory Anthrax Disease

Gastrointestinal Anthrax

Parkinson Disease 17

PARK17	Parkinson'S Disease 17
Autosomal Dominant Parkinson Disease 17	Parkinson Disease, Type 17

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149394	PRDX1-IN-1		98.04%	Unkown
HY-122936	Tanshindiol C		98.47%	Unkown
HY-133541	Glucopiericidin A		/	Unkown
HY-158368	PRDX1-IN-2	Inhibitor	/	Unkown
HY-171272	PRDX1-IN-3		/	Unkown
HY-RS11074	PRDX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRDX1	MGD	MGI:99523
Rattus norvegicus	PRDX1	RGD	RGD:620039
Macaca mulatta	PRDX1	VGNC	VGNC:100047
Felis catus	PRDX1	VGNC	VGNC:107605
Bos taurus	PRDX1	VGNC	VGNC:33299
Others	PRDX1	NCBI

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