MTERF3 - mitochondrial transcription termination factor 3 Gene

Homo sapiens

Also known as CGI-12; MTERFD1

Gene ID: 51001 | Gene type: protein coding

About MTERF3

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:96,239,398-96,261,613 (from NCBI)

This gene has 5 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in adrenal (RPKM 7.1), appendix (RPKM 6.9) and 25 other tissues.

Summary

Enables transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MTERF3 Products(3)

mRNA	Protein	Name
NM_001286643.1	NP_001273572.1	transcription termination factor 3, mitochondrial isoform 2 precursor
NM_001362964.1	NP_001349893.1	transcription termination factor 3, mitochondrial isoform 3
NM_015942.5	NP_057026.3	transcription termination factor 3, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17662942	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17662942	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	17662942	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTERF3 Protein Structure

mTERF

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

transcription termination factor 3, mitochondrial

MTERF domain containing 1

MTERF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MTERF3	Q96E29	ADGRE2	Homo sapiens	Q9UHX3	Validated Y2H	32296183
Intra	MTERF3	Q96E29	GPR108	Homo sapiens	Q9NPR9	Validated Y2H	32296183
Intra	MTERF3	Q96E29	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	MTERF3	Q96E29	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	MTERF3	Q96E29	SYNGR1	Homo sapiens	O43759-2	Y2H Array	32296183
Intra	MTERF3	Q96E29	SYNGR1	Homo sapiens	O43759-2	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	APOC1	Homo sapiens	P02654	Y2H Array	32296183
Intra	MTERF3	Q96E29	APOC1	Homo sapiens	P02654	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	HIGD1C	Homo sapiens	A8MV81	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	HIGD1C	Homo sapiens	A8MV81	Y2H Array	32296183
Intra	MTERF3	Q96E29	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	MTERF3	Q96E29	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	MTERF3	Q96E29	TMEM14C	Homo sapiens	Q9P0S9	Y2H Array	32296183
Intra	MTERF3	Q96E29	TMEM14C	Homo sapiens	Q9P0S9	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	MTERF3	Q96E29	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	MTERF3	Q96E29	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	ZDHHC21	Homo sapiens	Q8IVQ6	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	ZDHHC21	Homo sapiens	Q8IVQ6	Y2H Array	32296183
Intra	MTERF3	Q96E29	FUNDC1	Homo sapiens	Q8IVP5	Y2H Prey Pooling	25416956
Intra	MTERF3	Q96E29	FUNDC1	Homo sapiens	Q8IVP5	Validated Y2H	25416956
Intra	MTERF3	Q96E29	FUNDC1	Homo sapiens	Q8IVP5	Y2H Array	25416956
Intra	MTERF3	Q96E29	SLC17A9	Homo sapiens	Q9BYT1	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	SLC17A9	Homo sapiens	Q9BYT1	Validated Y2H	32296183
Intra	MTERF3	Q96E29	SLC17A9	Homo sapiens	Q9BYT1	Y2H Array	32296183
Intra	MTERF3	Q96E29	FADS6	Homo sapiens	Q8N9I5	Y2H Array	32296183
Intra	MTERF3	Q96E29	FADS6	Homo sapiens	Q8N9I5	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	MTERF3	Q96E29	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
Intra	MTERF3	Q96E29	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	25416956
Intra	MTERF3	Q96E29	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	MTERF3	Q96E29	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	MTERF3	Q96E29	AGTRAP	Homo sapiens	Q6RW13	Y2H Array	25416956
Intra	MTERF3	Q96E29	SLC50A1	Homo sapiens	Q9BRV3	Validated Y2H	32296183
Intra	MTERF3	Q96E29	SLC50A1	Homo sapiens	Q9BRV3	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	SLC50A1	Homo sapiens	Q9BRV3	Y2H Array	32296183
Intra	MTERF3	Q96E29	CACFD1	Homo sapiens	Q9UGQ2	Validated Y2H	32296183
Intra	MTERF3	Q96E29	CACFD1	Homo sapiens	Q9UGQ2	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	CACFD1	Homo sapiens	Q9UGQ2	Y2H Array	32296183
Intra	MTERF3	Q96E29	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	MTERF3	Q96E29	MAL2	Homo sapiens	Q969L2	Y2H Array	32296183
Intra	MTERF3	Q96E29	MAL2	Homo sapiens	Q969L2	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	SCAMP1	Homo sapiens	O15126	Y2H Prey Pooling	32296183
Intra	MTERF3	Q96E29	SCAMP1	Homo sapiens	O15126	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spastic Paraplegia 7, Autosomal Recessive

SPG7	Hereditary Spastic Paraplegia 7
Spastic Paraplegia Type 7	Spastic Paraplegia 7
Hereditary Spastic Paraplegia, Paraplegin Type	Autosomal Recessive Spastic Paraplegia 7
Hereditary Spastic Paraplegia Paraplegin Type	Spastic Paraplegia-7
Paraplegia, Spastic, Autosomal Recessive, Type 7	Spastic Paraplegia, Hereditary
Autosomal Recessive Hereditary Spastic Paraplegia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08763	MTERF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MTERF3	RGD	RGD:735158
Macaca mulatta	MTERF3	VGNC	VGNC:74817
Mus musculus	MTERF3	MGD	MGI:1913660
Canis familiaris	MTERF3	VGNC	VGNC:43465
Felis catus	MTERF3	VGNC	VGNC:63645
Bos taurus	MTERF3	VGNC	VGNC:31721

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