2. Gene
  3. MRPL4 - mitochondrial ribosomal protein L4 Gene

MRPL4 - mitochondrial ribosomal protein L4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as L4mt; CGI-28

Gene ID: 51073 | Gene type: protein coding

About MRPL4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,251,951-10,260,055 (from NCBI)

This gene has 11 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in kidney (RPKM 9.6), fat (RPKM 9.1) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

MRPL4 Products(4)

mRNA Protein Name
NM_001411149.1 NP_001398078.1 39S ribosomal protein L4, mitochondrial isoform c
NM_015956.3 NP_057040.2 39S ribosomal protein L4, mitochondrial isoform a
NM_146387.2 NP_666499.1 39S ribosomal protein L4, mitochondrial isoform a
NM_146388.2 NP_666500.1 39S ribosomal protein L4, mitochondrial isoform b

MRPL4 Protein Structure

Ribosomal_L4

Ribosomal_L4: Ribosomal protein L4/L1 family (81 - 271)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

39S ribosomal protein L4, mitochondrial

MRP-L4

MRPL4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MRPL4 Q9BYD3 LITAF Homo sapiens Q99732
Validated Y2H
32814053
Intra
MRPL4 Q9BYD3 LITAF Homo sapiens Q99732
Y2H Pooling
32814053
Intra
MRPL4 Q9BYD3 LITAF Homo sapiens Q99732
Y2H Array
32814053
Intra
MRPL4 Q9BYD3 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
MRPL4 Q9BYD3 CLK2 Homo sapiens P49760
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dyskinetic Cerebral Palsy

Athetoid Cerebral Palsy

Athetoid Dyskinetic Cerebral Palsy

Cerebral Palsy Athetoid

Cerebral Palsy Dyskinetic

Athetoid Cerebral Paralysis

Dyskinetic Cerebral Paralysis

Vogt Disease

Athetoid Cerebrum Palsy

Double Athetosis Syndrome

État Marbré
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08671 MRPL4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MRPL4 VGNC VGNC:102645
Rattus norvegicus MRPL4 RGD RGD:1311777
Canis familiaris MRPL4 VGNC VGNC:43397
Mus musculus MRPL4 MGD MGI:2137210
Bos taurus MRPL4 VGNC VGNC:31635
Macaca mulatta MRPL4 VGNC VGNC:74750
Others MRPL4 NCBI