2. Gene
  3. CLK2 - CDC like kinase 2 Gene

CLK2 - CDC like kinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 1196 | Gene type: protein coding

About CLK2

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,262,868-155,273,504 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 269 orthologues and 12 paralogues. Ubiquitous expression in spleen (RPKM 18.0), lymph node (RPKM 16.4) and 25 other tissues.

Summary

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

CLK2 Products(4)

mRNA Protein Name
NM_001294338.2 NP_001281267.1 dual specificity protein kinase CLK2 isoform 1
NM_001294339.2 NP_001281268.1 dual specificity protein kinase CLK2 isoform 3
NM_001363704.2 NP_001350633.1 dual specificity protein kinase CLK2 isoform 4
NM_003993.4 NP_003984.2 dual specificity protein kinase CLK2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10480872 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9637771 GOA
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
9637771 GOA
involved in response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
20682768 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
9637771 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (163 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
Protein Preferred Names Protein Names

dual specificity protein kinase CLK2

CLK kinase

Related Diseases

Diseases Alias
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-144875 CTX-712 Inhibitor 98.60% Phase 2
HY-137443 Ipivivint Inhibitor 99.65% Phase 1
Pre-clinical Phase
Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115470 CLK-IN-T3 Inhibitor 98.63% Unkown
HY-147141 HS-276 Inhibitor 98.59% Unkown
HY-112296 T025 98.84% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-108709 CC-671 Inhibitor 99.06% Unkown
HY-123600 SRI-29329 Inhibitor 99.73% Unkown
HY-132175 CK2 inhibitor 2 Inhibitor 98.51% Unkown
HY-149262 CLK1-IN-3 98.03% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-131978 DB18 Inhibitor 98.27% Unkown
HY-113825 CLK1/2-IN-1 Inhibitor / Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-113670 CLK1/2-IN-2 Inhibitor / Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-125202 KuWal151 Inhibitor / Unkown
HY-155723 Leucettinib-92 Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-162398 LQ23 Inhibitor / Unkown
HY-168209 LBM22 / Unkown
HY-RS02817 CLK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-153708 SGC-CLK-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLK2 VGNC VGNC:27449
Rattus norvegicus CLK2 RGD RGD:1359711
Felis catus CLK2 VGNC VGNC:107859
Canis familiaris CLK2 VGNC VGNC:39347
Mus musculus CLK2 MGD MGI:1098669
Macaca mulatta CLK2 VGNC VGNC:71259
Others CLK2 NCBI