THAP4 - THAP domain containing 4 Gene

Homo sapiens

Also known as PP238; CGI-36; Nb(III)

Gene ID: 51078 | Gene type: protein coding

About THAP4

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,584,405-241,637,576 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 14.3), heart (RPKM 13.9) and 25 other tissues.

Summary

Enables several functions, including heme binding activity; identical protein binding activity; and peroxynitrite isomerase activity. Involved in nitrate metabolic process and tyrosine metabolic process. [provided by Alliance of Genome Resources, Apr 2022]

THAP4 Products(2)

mRNA	Protein	Name
NM_001164356.2	NP_001157828.1	peroxynitrite isomerase THAP4 isoform 2
NM_015963.6	NP_057047.4	peroxynitrite isomerase THAP4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables heme binding	IMP IMP: Inferred from mutant phenotype	21387410	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21387410	GOA
enables nitric oxide binding	IDA IDA: Inferred from direct assay	30524950	GOA
enables peroxynitrite isomerase activity	IDA IDA: Inferred from direct assay	30524950	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nitrate metabolic process	IDA IDA: Inferred from direct assay	30524950	GOA
involved in tyrosine metabolic process	IDA IDA: Inferred from direct assay	30524950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THAP4 Protein Structure

THAP

DUF1794

0
100
200
300
400
500
577 a.a.

Protein Preferred Names

Protein Names

peroxynitrite isomerase THAP4

THAP domain-containing protein 4

Related Diseases

Diseases

Alias

Venous Hemangioma

Chromosome 2q37 Deletion Syndrome

Albright Hereditary Osteodystrophy-Like Syndrome	2q37 Microdeletion Syndrome
Brachydactyly-Intellectual Disability Syndrome	Deletion 2q37
2q37 Deletion Syndrome	Brachydactyly-Mental Retardation Syndrome
Bdmr	Albright Hereditary Osteodystrophy Type 3
Del(2)(Q37)	Monosomy 2q37qter
Albright'S Hereditary Osteodystrophy-Like Syndrome	Monosomy 2q37
Chromosome Deletion Syndrome 2q37

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14475	THAP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THAP4	VGNC	VGNC:99410
Mus musculus	THAP4	MGD	MGI:1914276
Felis catus	THAP4	VGNC	VGNC:80379
Rattus norvegicus	THAP4	RGD	RGD:1359473
Canis familiaris	THAP4	VGNC	VGNC:59098
Bos taurus	THAP4	VGNC	VGNC:55691

Name
Email *

	Sorry, but the email address you supplied was invalid.