2. Gene
  3. CLEC1A - C-type lectin domain family 1 member A Gene

CLEC1A - C-type lectin domain family 1 member A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CLEC1; CLEC-1

Gene ID: 51267 | Gene type: protein coding

About CLEC1A

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,069,554-10,098,985 (from NCBI)

This gene has 5 transcripts (splice variants), 370 orthologues, 23 paralogues and is associated with 1 phenotype. Biased expression in placenta (RPKM 18.1), lung (RPKM 3.8) and 10 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to Other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CLEC1A Products(5)

mRNA Protein Name
NM_001297748.2 NP_001284677.1 C-type lectin domain family 1 member A isoform b
NM_001297749.2 NP_001284678.1 C-type lectin domain family 1 member A isoform c
NM_001297750.2 NP_001284679.1 C-type lectin domain family 1 member A isoform d
NM_001297751.2 NP_001284680.1 C-type lectin domain family 1 member A isoform d
NM_016511.4 NP_057595.2 C-type lectin domain family 1 member A isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC1A Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (155 - 259)

  • 0
  • 100
  • 200
  • 280 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 1 member A

C-type lectin-like receptor-1

CLEC1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CLEC1A Q8NC01 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
CLEC1A Q8NC01 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
CLEC1A Q8NC01 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
CLEC1A Q8NC01 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
CLEC1A Q8NC01 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
CLEC1A Q8NC01 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 CLEC12A Homo sapiens Q5QGZ9
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 CLEC12A Homo sapiens Q5QGZ9
Y2H Array
32296183
Intra
CLEC1A Q8NC01 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
CLEC1A Q8NC01 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
CLEC1A Q8NC01 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
CLEC1A Q8NC01 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra
CLEC1A Q8NC01 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
CLEC1A Q8NC01 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
CLEC1A Q8NC01 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
CLEC1A Q8NC01 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
CLEC1A Q8NC01 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra
CLEC1A Q8NC01 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
CLEC1A Q8NC01 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 MRPS18B Homo sapiens Q9Y676
Y2H Array
32296183
Intra
CLEC1A Q8NC01 MRPS18B Homo sapiens Q9Y676
Y2H Prey Pooling
32296183
Intra
CLEC1A Q8NC01 MRPS18B Homo sapiens Q9Y676
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC1A Proteins

Cat. No. Product Name Accession Purity
HY-P75338 CLEC-1/CLEC1A Protein, Human (HEK293, Fc) Q8NC01/NP_057595.2 (Q77-D280) ≥95%

Related Diseases

Diseases Alias
Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus
Glioblastoma Proneural Subtype
White Piedra

Tinea Blanca

Trichosporosis Nodosa
Autoimmune Atherosclerosis
Subcutaneous Mycosis

Subcutaneous Fungal Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02785 CLEC1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CLEC1A VGNC VGNC:71335
Bos taurus CLEC1A VGNC VGNC:27427
Mus musculus CLEC1A MGD MGI:2444151
Rattus norvegicus CLEC1A RGD RGD:1566110
Felis catus CLEC1A VGNC VGNC:83534
Others CLEC1A NCBI