2. Gene
  3. MED15 - mediator complex subunit 15 Gene

MED15 - mediator complex subunit 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105

Gene ID: 51586 | Gene type: protein coding

About MED15

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,507,610-20,587,619 (from NCBI)

This gene has 31 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in spleen (RPKM 10.5), bone marrow (RPKM 9.5) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

MED15 Products(6)

mRNA Protein Name
NM_001003891.3 NP_001003891.1 mediator of RNA polymerase II transcription subunit 15 isoform a
NM_001293234.2 NP_001280163.1 mediator of RNA polymerase II transcription subunit 15 isoform c
NM_001293235.2 NP_001280164.1 mediator of RNA polymerase II transcription subunit 15 isoform d
NM_001293236.2 NP_001280165.1 mediator of RNA polymerase II transcription subunit 15 isoform e
NM_001293237.2 NP_001280166.1 mediator of RNA polymerase II transcription subunit 15 isoform d
NM_015889.5 NP_056973.2 mediator of RNA polymerase II transcription subunit 15 isoform b
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16799563 GOA
Cellular Component GO Annotation Evidence Reference Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24882805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED15 Protein Structure

Med15

Med15: ARC105 or Med15 subunit of Mediator complex non-fungal (17 - 784)

  • 0
  • 200
  • 400
  • 600
  • 788 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 15

CTG repeat protein 7a

MED15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MED15 Q96RN5 MED14 Homo sapiens O60244
Anti Tag CoIP
24882805
Intra MED15 Q96RN5 MED25 Homo sapiens Q71SY5
Anti Tag CoIP
24882805
Intra MED15 Q96RN5 SREBF2 Homo sapiens Q12772
Pull Down
16799563
Intra MED15 Q96RN5 HTT Homo sapiens P42858
Y2H
17500595
Intra MED15 Q96RN5 TRIM11 Homo sapiens Q96F44
Imaging
16904669
Intra MED15 Q96RN5 TRIM11 Homo sapiens Q96F44
Anti Tag CoIP
16904669
Intra MED15 Q96RN5 SREBF1 Homo sapiens P36956-1
Pull Down
18385733
Intra MED15 Q96RN5 SREBF1 Homo sapiens P36956-3
Pull Down
16799563
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome

DGS

Hypoplasia Of Thymus And Parathyroids

Third And Fourth Pharyngeal Pouch Syndrome

22q11.2 Deletion Syndrome

Digeorge Sequence

Digeorge'S Syndrome

Pharyngeal Pouch Syndrome

Di-George Syndrome

Shprintzen Syndrome
Ureterocele
Velocardiofacial Syndrome

Shprintzen Syndrome

VCFS

Chromosome 22q11.2 Deletion Syndrome

Vcf Syndrome

Shprintzen Vcf Syndrome

Vcf-Velocardiofacial Syndrome

Velo-Cardio-Facial Syndrome

Digeorge Syndrome

22q11 Deletion Syndrome

Conotruncal Anomaly Face Syndrome
Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

22q11.2 Distal Deletion Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2, Distal
Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08286 MED15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MED15 VGNC VGNC:74511
Rattus norvegicus MED15 RGD RGD:1307560
Canis familiaris MED15 VGNC VGNC:43125
Mus musculus MED15 MGD MGI:2137379
Bos taurus MED15 VGNC VGNC:31353