LSM2 - LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Homo sapiens

Also known as G7B; snRNP; C6orf28; YBL026W

Gene ID: 57819 | Gene type: protein coding

About LSM2

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,797,396-31,806,966 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in lymph node (RPKM 15.9), appendix (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

LSM2 Products(1)

mRNA	Protein	Name
NM_021177.5	NP_067000.1	U6 snRNA-associated Sm-like protein LSm2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within mRNA catabolic process	IDA IDA: Inferred from direct assay	12515382	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
acts upstream of or within spliceosomal tri-snRNP complex assembly	IDA IDA: Inferred from direct assay	10523320	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12515382	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10523320	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM2 Protein Structure

LSM

0
95 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm2

LSM2 U6 small nuclear RNA and mRNA degradation associated

LSM2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LSM2	Q9Y333	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	LSM2	Q9Y333	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	15231747
Intra	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	22365833
Intra	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	14667819
Intra	LSM2	Q9Y333	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H	15231747
Intra	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H Array	32296183
Intra	LSM2	Q9Y333	ZNF408	Homo sapiens	Q9H9D4	Y2H	14667819
Intra	LSM2	Q9Y333	ZNF408	Homo sapiens	Q9H9D4	Y2H	15231747
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	GMS	19628699
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	22365833
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	14667819
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	15231747
Intra	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Ion Exchange Chrom	19628699
Intra	LSM2	Q9Y333	SNRPE	Homo sapiens	P62304	Y2H	14667819
Intra	LSM2	Q9Y333	SNRPE	Homo sapiens	P62304	Y2H	15231747
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Pooling	16169070
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	GMS	19628699
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	21516116
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Lumier	37398436
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	31467278
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Ion Exchange Chrom	19628699
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	25416956
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	SLC	31467278
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	SLC	27107012
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	14667819
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	15231747
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	BRET	37398436
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	BFG-2H	27107012
Intra	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	32296183
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	22365833
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	14667819
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Ion Exchange Chrom	19628699
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	GMS	19628699
Intra	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H Array	32296183
Intra	LSM2	Q9Y333	SNRPB	Homo sapiens	P14678-2	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	SNRPB	Homo sapiens	P14678-2	Y2H Array	32296183
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Ion Exchange Chrom	19628699
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	GMS	19628699
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H Array	32296183
Intra	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H	22365833
Intra	LSM2	Q9Y333	MAGEA3	Homo sapiens	P43357	Y2H Array	32296183
Intra	LSM2	Q9Y333	MAGEA3	Homo sapiens	P43357	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	LSM2	Q9Y333	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H	22365833
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Array	25416956
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Array	32296183
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Validated Y2H	25416956
Intra	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM12	Homo sapiens	Q3MHD2	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	LSM12	Homo sapiens	Q3MHD2	Y2H Array	32296183
Intra	LSM2	Q9Y333	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	LSM2	Q9Y333	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	LSM2	Q9Y333	DNAAF11	Homo sapiens	Q86X45	Y2H Prey Pooling	32296183
Intra	LSM2	Q9Y333	DNAAF11	Homo sapiens	Q86X45	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mixed Connective Tissue Disease

Sharp Syndrome	Mctd
Connective Tissue Disease Overlap Syndrome	Mixed Collagen Vascular Disease
Mctd - [Mixed Connective Tissue Disease]

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07857	LSM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LSM2	VGNC	VGNC:81088
Bos taurus	LSM2	VGNC	VGNC:31054
Felis catus	LSM2	VGNC	VGNC:102452
Rattus norvegicus	LSM2	RGD	RGD:1598536
Mus musculus	LSM2	MGD	MGI:90676

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