LSM2 - LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Homo sapiens

Also known as G7B; snRNP; C6orf28; YBL026W

Gene ID: 57819 | Gene type: protein coding

About LSM2

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,797,396-31,806,966 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in lymph node (RPKM 15.9), appendix (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

LSM2 Products(1)

mRNA	Protein	Name
NM_021177.5	NP_067000.1	U6 snRNA-associated Sm-like protein LSm2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within mRNA catabolic process	IDA IDA: Inferred from direct assay	12515382	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
acts upstream of or within spliceosomal tri-snRNP complex assembly	IDA IDA: Inferred from direct assay	10523320	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12515382	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10523320	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM2 Protein Structure

LSM

0
95 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm2

LSM2 U6 small nuclear RNA and mRNA degradation associated

Related Diseases

Diseases

Alias

Mixed Connective Tissue Disease

Sharp Syndrome	Mctd
Connective Tissue Disease Overlap Syndrome	Mixed Collagen Vascular Disease
Mctd - [Mixed Connective Tissue Disease]

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07857	LSM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LSM2	VGNC	VGNC:81088
Bos taurus	LSM2	VGNC	VGNC:31054
Felis catus	LSM2	VGNC	VGNC:102452
Rattus norvegicus	LSM2	RGD	RGD:1598536
Mus musculus	LSM2	MGD	MGI:90676

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